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Ion Channels pp 55–89Cite as

Potassium Channels: Oncogenic Potential and Therapeutic Target for Cancers

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Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 3))

Abstract

Cell proliferation and cell death are two counterparts in sharing the responsibility for maintaining normal body function, and the delicate balance between the two coordinates developmental morphogenesis, cell homeostasis, and tissue modeling in organisms. Abnormally enhanced proliferation and/or impaired cell death often cause loss of control of cell growth leading to tumorigenesis or cancer formation. Several fundamental steps need to be fulfilled at the cellular level for tumorigenesis and these steps can be roughly viewed as characteristic alterations of some physicochemical processes: cell volume, intracellular Ca2+, and intracellular pH. Evidence has rapidly emerged indicating a pivotal role of K+ channels in controlling these fundamental biological processes and a deregulated expression of potassium channel protein-coding genes, as well as malfunction of K+ channels as an important step in the development and progression of cancers. Herein, the role of K+ channels in cancer progression will be introduced by presenting the data obtained over the past 25 years, beginning with the evidence for K+ channels as cancer markers, followed by the data linking K+ channels to neoplastic growth and cancer metastasis. The potential of targeting K+ channels for cancer therapy will then be discussed by outlining the promising approaches and strategies including inhibition of K+ channel activities using pharmacological agents and downregulation of K+ channel expression using various nucleic acids (siRNA, decoy ODN and miRNA). Some unanswered questions and unsolved problems with respect to K+ channels and cancer are discussed in the final section.

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  1. Research Center, Montreal Heart Institute, University of Montreal, PQ H1T 1C8, Montreal, Canada

    Zhiguo Wang

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  1. Zhiguo Wang
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Correspondence to Zhiguo Wang .

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Bernard Fermini Birgit T. Priest

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© 2008 Springer-Verlag Berlin Heidelberg

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Wang, Z. (2008). Potassium Channels: Oncogenic Potential and Therapeutic Target for Cancers. In: Fermini, B., Priest, B.T. (eds) Ion Channels. Topics in Medicinal Chemistry, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2008_020

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