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Therapeutic Approaches for the Treatment of Alzheimer's Disease: An Overview

Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 2)

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. Aging and other risk factors (e.g. cardiovascular diseases, obesity and diabetes) in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow, stop or reverse the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which come many ideas for intervening in its progression. They can be grossly categorized into those targeting the amyloid pathology, tau pathology, microgliosis (neuroinflammation) and functional deficits. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases while others represent novel chemical entities. Our continued commitment in searching for efficacious treatments together with a healthier lifestyle will be important in fighting against the growing threat of this deteriorating disease.

Aβ Alzheimer's disease Amyloid Microgliosis Neurodegeneration tau 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.CNS Discovery, Pfizer Global Research and DevelopmentGrotonUSA

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