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GSK-3 Inhibitors for the Treatment of Alzheimer's Disease

Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 2)

Abstract

Glycogen synthase kinase 3 (GSK-3) has emerged as a prominent therapeutic target for intervention in several diseases including non-insulin-dependent diabetes mellitus, Alzheimer's disease, stroke, bipolar disorder and affective disorders. In the present review we briefly summarise the properties of GSK-3, focusing primarily on the role of GSK-3 in Alzheimer's disease. Furthermore, we discuss the potential for therapeutic benefit of GSK-3 inhibitors.

Glycogen synthase kinase 3 Alzheimer's disease Tau Beta amyloid 

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References

  1. 1.
    Plyte SE, Hughes K, Nikolakaki E, Pulverer BJ, Woodgett JR (1992) Biochim Biophys Acta 1114:147 Google Scholar
  2. 2.
    Woodgett JR (1990) EMBO J 9:2431 Google Scholar
  3. 3.
    Lau KF, Miller CC, Anderton BH, Shaw PC (1999) J Pept Res 54:85 Google Scholar
  4. 4.
    Leroy K, Brion JP (1999) J Chem Neuroanat 16:279 Google Scholar
  5. 5.
    Yao HB, Shaw PC, Wong CC, Wan DC (2002) J Chem Neuroanat 23:291 Google Scholar
  6. 6.
    Woodgett JR (1991) Methods Enzymol 200:564 CrossRefGoogle Scholar
  7. 7.
    Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR (2000) Nature 406:86 Google Scholar
  8. 8.
    Spittaels K, Van Den Haute C, Van Dorpe J, Terwel D, Vandezande K, Lasrado R, Bruynseels K, Irizarry M, Verhoyle M, Van Lint J, Vandeenheede JR, Ashton D, Mercken M, Loos R, Hyman B, Van Der Linden A, Geerts H, Van Leuven F (2002) Neuroscience 13:797 Google Scholar
  9. 9.
    Embi N, Rylatt DB, Cohen P (1980) Eur J Biochem 107:519 CrossRefGoogle Scholar
  10. 10.
    Frame S, Cohen P, Biondi RM (2001) Mol Cell 7:1321 Google Scholar
  11. 11.
    Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR (1993) EMBO J 12:803 Google Scholar
  12. 12.
    Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH (2001) Cell 105:721 Google Scholar
  13. 13.
    Cross DA, Culbert AA, Chalmers KA, Facci L, Skaper SD, Reith AD (2001) J Neurochem 77:94 CrossRefGoogle Scholar
  14. 14.
    Cohen P, Frame S (2001) Nat Rev Mol Cell Biol 2:769 Google Scholar
  15. 15.
    Cole A, Frame S, Cohen P (2004) Biochem J 377:249 Google Scholar
  16. 16.
    Liang MH, Chuang DM (2007) J Biol Chem 282:3904 Google Scholar
  17. 17.
    Kockeritz L, Doble B, Patel S, Woodgett JR (2006) Curr Drug Targets 7:1377 Google Scholar
  18. 18.
    Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (1999) J Neuropathol Exp Neurol 58:1010 Google Scholar
  19. 19.
    Li X, Friedman AB, Roh MS, Jope RS (2005) J Neurochem 92:701 Google Scholar
  20. 20.
    Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A (2006) ChemMedChem 1:256 Google Scholar
  21. 21.
    Pérez M, Hernandez F, Gomez-Ramos A, Smith M, Perry G, Avila J (2002) Eur J Biochem 269:1484 Google Scholar
  22. 22.
    Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurology 42:631 Google Scholar
  23. 23.
    Nagy Z, Esiri MM, Jobst KA, Morris JH, King EM, McDonald B, Litchfield S, Smith A, Barnetson L, Smith AD (1995) Dementia 6:21 Google Scholar
  24. 24.
    Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS (2005) Science 307:1282 Google Scholar
  25. 25.
    Lee VM, Goedert M, Trojanowski JQ (2001) Annu Rev Neurosci 24:1121 Google Scholar
  26. 26.
    Drechsel DN, Hyman AA, Cobb MH, Kirschner MW (1992) Mol Biol Cell 3:1141 Google Scholar
  27. 27.
    Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Brain Res Rev 33:95 Google Scholar
  28. 28.
    Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J (2001) EMBO J 20:27 Google Scholar
  29. 29.
    Hernandez F, Borrell J, Guaza C, Avila J, Lucas JJ (2002) J Neurochem 83:1529 Google Scholar
  30. 30.
    Lisman J, Lichtman JW, Sanes JR (2003) Nat Rev Neurosci 4:926 Google Scholar
  31. 31.
    Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S (2007) Eur J Neurosci 25:81 Google Scholar
  32. 32.
    Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JT, Bortolotto ZA, Wang YT, Collingridge GL (2007) Neuron 53:703 Google Scholar
  33. 33.
    Pap M, Cooper GM (1998) J Biol Chem 273:19929 Google Scholar
  34. 34.
    King TD, Bijur GN, Jope RS (2001) Brain Res 919:106 Google Scholar
  35. 35.
    Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K (1993) Proc Natl Acad Sci USA 90:7789 Google Scholar
  36. 36.
    Shin SY, Kim CG, Jho EH, Rho MS, Kim YS, Kim YH, Lee YH (2004) Cancer Lett 212:225 Google Scholar
  37. 37.
    Bhat RV, Leonov S, Luthman J, Scott CW, Lee CM (2002) J Alzheimers Dis 4:291 Google Scholar
  38. 38.
    Phiel CJ, Wilson CA, Lee VM, Klein PS (2003) Nature 423:435 Google Scholar
  39. 39.
    Ryder J, Su Y, Liu F, Li B, Zhou Y, Ni B (2003) Biochem Biophys Res Commun 312:922 Google Scholar
  40. 40.
    Su Y, Ryder J, Li B, Wu X, Fox N, Solenberg P, Brune K, Paul S, Zhou Y, Liu F, Ni B (2004) Biochemistry 43:6899 Google Scholar
  41. 41.
    Rockenstein E, Torrance M, Adame A, Mante M, Baron P, Rose JB, Crews L, Masliah E (2007) J Neurosci 27:1981 Google Scholar
  42. 42.
    Takashima A, Murayama M, Murayama O, Kohno T, Honda T, Yasutake K, Nihonmatsu N, Mercken M, Yamaguchi H, Sugihara S, Wolozin B (1998) Proc Natl Acad Sci USA 95:9637 Google Scholar
  43. 43.
    Akiyama H, Shin RW, Uchida C, Kitamoto T, Uchida T (2005) Biochem Biophys Res Commun 336:521 Google Scholar
  44. 44.
    Mukai F, Ishiguro K, Sano Y, Fujita SC (2002) J Neurochem 81:1073 Google Scholar
  45. 45.
    Shaffer B, Wiedau-Pazos M, Geschwind DH (2003) Gene 302:73 Google Scholar
  46. 46.
    Knight ZA, Shokat KM (2005) Chem Biol 12:621 Google Scholar
  47. 47.
    Ainscow EK, Mirshamsi S, Tang T, Ashford MLJ, Rutter GA (2002) J Physiol 544:429 Google Scholar
  48. 48.
    Ter Haar E, Swenson L, Green J, Arnost MJ (2002) PCT Int Appl WO Patent 2002088078 Google Scholar
  49. 49.
    Fischer P (2003) Chem Biol 10:1144 Google Scholar
  50. 50.
    Bax B, Carter PS, Lewis C, Guy AR, Bridges A, Tanner R, Pettman G, Mannix C, Culbert AA, Brown MJ, Smith DG, Reith AD (2001) Structure 9:1143 Google Scholar
  51. 51.
    Chen G, Huang L-D, Jiang Y-M, Manji HK (1999) J Neurochem 72:1327 Google Scholar
  52. 52.
    Huang H-C, Klein PS (2006) Curr Drug Targets 7:1389 Google Scholar
  53. 53.
    Chou H-Y, Howng S-L, Cheng T-S, Hsiao Y-L, Lieu A-S, Loh J-K, Hwang S-L, Lin C-C, Hsu C-M, Wang C, Lee C-I, Lu P-J, Chou C-K, Huang C-Y, Hong Y-R (2006) Biochemistry 45:11379 Google Scholar
  54. 54.
    Klein PS, Melton DA (1996) Proc Natl Acad Sci USA 93:8455 Google Scholar
  55. 55.
    Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR (2000) Chem Biol 7:51 Google Scholar
  56. 56.
    Churcher I (2006) Curr Top Med Chem 6:579 Google Scholar
  57. 57.
    Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L (2001) J Biol Chem 276:251 Google Scholar
  58. 58.
    Bhat RV, Xue Y, Berg S, Hellberg S, Ormö M, Nilsson Y, Radesäter A-C, Jerning E, Markgren P-O, Borgegård T, Nylöf M, Giménez-Cassina A, Hernández F, Lucas JJ, Díaz-Nido J, Avila J (2003) J Biol Chem 278:45937 Google Scholar
  59. 59.
    Berg S, Hellberg S (2003) PCT Int Appl WO Patent 2003004472 Google Scholar
  60. 60.
    Berg S, Bhat R, Edwards P, Hellberg S (2003) PCT Int Appl WO Patent 2003055492 Google Scholar
  61. 61.
    Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, Pearce NJ, Rausch OL, Murphy GJ, Carter PS, Roxbee Cox L, Mills D, Brown MJ, Haigh D, Ward RW, Smith DG, Murray KJ, Reith AD, Holder JC (2000) Chem Biol 7:793 Google Scholar
  62. 62.
    Martinez A, Alonso M, Castro A, Perez C, Moreno FJ (2002) J Med Chem 45:1292 Google Scholar
  63. 63.
    Berridge MJ, Downes CP, Hanley MR (1989) Cell 59:411 Google Scholar
  64. 64.
    Davies SP, Reddy H, Caivano M, Cohen P (2000) Biochem J 351:95 Google Scholar
  65. 65.
    Chalecka-Franaszek E, Chuang DM (1999) Proc Natl Acad Sci USA 96:8745 Google Scholar
  66. 66.
    Yuan P, Chen G, Manji HK (1999) J Neurochem 73:2299 Google Scholar
  67. 67.
    Ryves WJ, Harwood AJ (2001) Biochem Biophys Res Commun 280:720 Google Scholar
  68. 68.
    Martell AE, Smith RM (1977) Critical Stability Constants, vol 6. Plenum Press, New York, p 286 Google Scholar
  69. 69.
    Munoz-Montano JR, Moreno FJ, Avila J, Diaz-Nido J (1997) FEBS Lett 411:183 Google Scholar
  70. 70.
    Hong M, Chen DC, Klein PS, Lee VM (1997) J Biol Chem 272:25326 Google Scholar
  71. 71.
    Lovestone S, Davis DR, Webster MT, Kaech S, Brion JP, Matus A, Anderton BH (1999) Biol Psychiatry 45:995 Google Scholar
  72. 72.
    Gomez-Ramos A, Abad X, Lopez Fanarraga M, Bhat R, Zabala JC, Avila J (2004) Brain Res 1007:57 Google Scholar
  73. 73.
    Sang H, Lu Z, Li Y, Ru B, Wang W, Chen J (2001) Neurosci Lett 312:141 Google Scholar
  74. 74.
    Mudher AK, Shepherd D, Newman TA, Mildren P, Jukes J-P, Berg S, Squire A, MacKay D, Asuni AA, Mears A, Bhat RV, Lovestone S (2004) Mol Psych 9:522 Google Scholar
  75. 75.
    Dou H, Ellison B, Bradley J, Kasiyanov A, Poluektova LY, Xiong H, Maggirwar S, Dewhurst S, Gelbard HA, Gendelman HE (2005) J Neurosci 25:8375 Google Scholar
  76. 76.
    Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, Dickson D, Duff K (2005) Proc Natl Acad Sci USA 102:6990 Google Scholar
  77. 77.
    Hawkes C, Jhamandas JH, Kar S (2005) J Neurochem 95:263 Google Scholar
  78. 78.
    Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2006) J Neurochem 99:1445 Google Scholar
  79. 79.
    Plattner F, Angelo M, Giese KP (2006) J Biol Chem 281:25457 Google Scholar
  80. 80.
    Sun X, Sato S, Murayama O, Murayama M, Park JM, Yamaguchi H, Takashima A (2002) Neurosci Lett 321:61 Google Scholar
  81. 81.
    Feyt C, Kienlen-Campard P, Leroy K, N'Kuli F, Courtoy PJ, Brion JP, Octave JN (2005) J Biol Chem 280:33220 Google Scholar
  82. 82.
    Norinder U, Sjoeberg P, Oesterberg T (1998) J Pharm Sci 87(8):952 Google Scholar
  83. 83.
    Vasdev N, Garcia A, Stableford WT, Young AB, Meyer JH, Houle S, Wilson AA (2005) Bioorg Med Chem Lett 15:5270 Google Scholar
  84. 84.
    Leost M, Schultz C, Link A, Wu YZ, Biernat J, Mandelkow EM, Bibb JA, Snyder GL, Greengard P, Zaharevitz DW, Gussio R, Senderowicz AM, Sausville EA, Kunick C, Meijer L (2000) Eur J Biochem 267:5983 Google Scholar
  85. 85.
    Takadera T, Ohyashiki T (2007) Brain Res 1133:20 Google Scholar
  86. 86.
    Ma MZ, Yao BY (1983) J Tradit Chin Med 3:245 Google Scholar
  87. 87.
    Jin N, Kovacs AD, Sui Z, Dewhurst S, Maggirwar SB (2005) Neuropharmacology 48:576 Google Scholar
  88. 88.
    Sui Z, Kovacs AD, Maggirwar SB (2006) Biochem Biophys Res Commun 345:1643 Google Scholar
  89. 89.
    Martinez A, Alonso M, Castro A, Dorronsoro I, Gelpi JL, Luque FJ, Perez C, Moreno FJ (2005) J Med Chem 48:7103 Google Scholar
  90. 90.
    Gould TD, Einat H, Bhat RV, Manji HK (2004) Int J Neuropsychopharmacol 26:1 Google Scholar
  91. 91.
    Hernández F, Pérez M, Lucas JJ, Mata AM, Bhat RV, Avila J (2004) J Biol Chem 279:3801 Google Scholar
  92. 92.
    Bhat RV, Budd Haeberlein SL, Lindquist JM (2006) Inhibition of GSK-3 as therapeutic strategy in disease: efficacy of AR-A014418. In: Martines A, Castro A, Medina M (eds) Glycogen synthase kinase 3 (GSK-3) and its inhibitors. Wiley, New Jersey, p 243 Google Scholar
  93. 93.
    Engler TA, Malhotra S, Burkholder TP, Henry JR, Mendel D, Porter WJ, Furness K, Diefenbacher C, Marquart A, Reel JK, Li Y, Clayton J, Cunningham B, McLean J, O'Toole JC, Brozinick J, Hawkins E, Misener E, Briere D, Brier RA, Wagner JR, Campbell RM, Anderson BD, Vaughn R, Bennett DB, Meier TI, Cook JA (2005) Bioorg Med Chem Lett 15:899 Google Scholar
  94. 94.
    Zhang F, Phiel CJ, Spece L, Gurvich N, Klein PS (2003) J Biol Chem 278:33067 Google Scholar
  95. 95.
    Lochhead PA, Coghlan M, Rice SQ, Sutherland C (2001) Diabetes 50:937 Google Scholar
  96. 96.
    Takadera T, Ohyashiki T (2006) Neurosci Lett 400(1–2):105 Google Scholar
  97. 97.
    Kozikowski AP, Gaisina IN, Petukhov PA, Sridhar J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A (2006) ChemMedChem 1:256 Google Scholar
  98. 98.
    Kozikowski AP, Gaisina IN, Petukhov PA, Sridahr J, King LT, Blond SY, Duka T, Rusnak M, Sidhu A (2006) ChemMedChem 1:256 Google Scholar
  99. 99.
    Chin PC, Majdzadeh N, D'Mello SR (2005) Brain Res Mol Brain Res 137:193 Google Scholar
  100. 100.
    Terao T, Nakano H, Inoue Y, Okamoto T, Nakamura J, Iwata N (2006) Prog Neuropsychopharmacol Biol Psychiatry 30:1125 Google Scholar
  101. 101.
    Annas P, Schröder J, Frölich L, Riepe M, Kraft I, Gasser T, Lehye T, Kurz A, Basun H, Hampel H (2006) J Alzheimer's Assoc 2:S257 Google Scholar
  102. 102.
    Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L (2006) Lancet Neurol 5:228 Google Scholar
  103. 103.
    Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Neuron 43:321 Google Scholar
  104. 104.
    Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Science 309:476 Google Scholar

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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.AstraZeneca R&D SödertäljeSödertäljeSweden

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