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GSK-3 Inhibitors for the Treatment of Alzheimer's Disease

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Alzheimer's Disease

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 2))

Abstract

Glycogen synthase kinase 3 (GSK-3) has emerged as a prominent therapeutic target for intervention in several diseases including non-insulin-dependent diabetes mellitus, Alzheimer's disease, stroke, bipolar disorder and affective disorders. In the present review we briefly summarise the properties of GSK-3, focusing primarily on the role of GSK-3 in Alzheimer's disease. Furthermore, we discuss the potential for therapeutic benefit of GSK-3 inhibitors.

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Authors and Affiliations

  1. AstraZeneca R&D Södertälje, B212, 501 E1, 15185, Södertälje, Sweden

    Ratan V. Bhat, Stefan Berg, Jeremy Burrows & Johanna Lindquist

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  1. Ratan V. Bhat
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  2. Stefan Berg
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  3. Jeremy Burrows
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  4. Johanna Lindquist
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Correspondence to Ratan V. Bhat .

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Lit-Fui Lau Michael A. Brodney

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Bhat, R.V., Berg, S., Burrows, J., Lindquist, J. (2007). GSK-3 Inhibitors for the Treatment of Alzheimer's Disease . In: Lau, LF., Brodney, M.A. (eds) Alzheimer's Disease. Topics in Medicinal Chemistry, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2007_015

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