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Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2 for Cancer Therapy

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Book cover Cancer

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 1))

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Abstract

Angiogenesis, the recruitment of new blood vessels, is a crucial mechanism required forboth tumor growth and metastasis. Advances in the understanding of the molecular mechanisms underlyingthe angiogenesis process have led to the discovery of a variety of pharmaceutical agents withantiangiogenic activity. The potential application of these angiogenesis inhibitors is currentlyunder intense clinical investigation. Decades of investigation suggest that vascular endothelialgrowth factor (VEGF) and its receptors, particularly VEGF receptor-2 (VEGFR-2, or kinase insert domain-containingreceptor, KDR), play a critical role in tumor-associated angiogenesis. VEGFR-2, therefore, representsa good target for therapeutic intervention. A number of agents designed selectively fortargeting VEGFR-2 are being evaluated in various phases of clinical trials in cancer patients. Thismanuscript reviews the biology of the VEGF family of ligands and receptors and of VEGFR-2 in particular.The attempts to develop effective VEGFR-2 antagonists, including small molecules, antibodies and others,for therapeutic purposes are discussed comprehensively with special emphasis on tumor angiogenesis.

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References

  1. Smith SK (1997) Semin Reprod Endocrinol 15:221

    Article  CAS  Google Scholar 

  2. Breier G (2000) Placenta 21(Suppl A):S11

    Article  Google Scholar 

  3. Tonnesen MG, Feng X, Clark RA (2000) J Investig Dermatol Symp Proc 5:40

    Article  CAS  Google Scholar 

  4. Gargett CE, Rogers PA (2001) Reproduction 121:181

    Article  CAS  Google Scholar 

  5. Smith SK (2001) Trend Endocrinol Metab 12:147

    Article  CAS  Google Scholar 

  6. Creamer D, Sullivan D, Bicknell R, Barker J (2002) Angiogenesis 5:231

    Article  CAS  Google Scholar 

  7. Funatsu H, Yamashita H, Noma H, Shimizu E, Yamashita T, Hori S (2001) Jpn J Ophthalmol 45:577

    Article  CAS  Google Scholar 

  8. Koch AE (2000) Ann Rheum Dis 59(Suppl 1):i65

    Article  Google Scholar 

  9. Tonini T, Rossi F, Claudio PP (2003) Oncogene 22:6549

    Article  CAS  Google Scholar 

  10. Arbiser JL (2004) Semin Cancer Biol 14:81

    Article  CAS  Google Scholar 

  11. Folkman J (1971) N Engl J Med 285:1182

    Article  CAS  Google Scholar 

  12. Folkman J (2002) Semin Oncol 29:15

    CAS  Google Scholar 

  13. Folkman J (2001) Semin Oncol 28:536

    Article  CAS  Google Scholar 

  14. Yance DR Jr, Sagar SM (2006) Integr Cancer Ther 5:9

    Article  CAS  Google Scholar 

  15. Dalgleish AG, O'Byrne K (2006) Cancer Treat Res 130:1

    Article  CAS  Google Scholar 

  16. de Castro Junior G, Puglisi F, de Azambuja E, El Saghir NS, Awada A (2006) Crit Rev Oncol Hematol 59:40

    Article  Google Scholar 

  17. Folkman J, Hanahan D (1991) Princess Takamatsu Symp 22:339

    CAS  Google Scholar 

  18. Giordano FJ, Johnson RS (2001) Curr Opin Genet Dev 11:35

    Article  CAS  Google Scholar 

  19. Huss WJ, Hanrahan CF, Barrios RJ, Simons JW, Greenberg NM (2001) Cancer Res 61:2736

    CAS  Google Scholar 

  20. Bergers G, Benjamin LE (2003) Nat Rev Cancer 3:401

    Article  CAS  Google Scholar 

  21. Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, McMahon G (1999) Cancer Res 59:99

    CAS  Google Scholar 

  22. Blagosklonny MV (2004) Cancer Cell 5:13

    Article  CAS  Google Scholar 

  23. Wu Y, Hooper AT, Zhong Z, Witte L, Bohlen P, Rafii S, Hicklin DJ (2006) Int J Cancer 119:1519

    Article  CAS  Google Scholar 

  24. Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, Somcio RJ, Wu Y, Hooper A, Hicklin DJ, Ellis LM (2005) Oncogene 24:2647

    Article  CAS  Google Scholar 

  25. Ferrara N (2000) Recent Prog Horm Res 55:15

    CAS  Google Scholar 

  26. Karkkainen MJ, Petrova TV (2000) Oncogene 19:5598

    Article  CAS  Google Scholar 

  27. Tille JC, Wang X, Lipson KE, McMahon G, Ferrara N, Zhu Z, Hicklin DJ, Sleeman JP, Eriksson U, Alitalo K, Pepper MS (2003) Exp Cell Res 285:286

    Article  CAS  Google Scholar 

  28. Veikkola T, Karkkainen M, Claesson-Welsh L, Alitalo K (2000) Cancer Res 60:203

    CAS  Google Scholar 

  29. Hicklin DJ, Ellis LM (2005) J Clin Oncol 23:1011

    Article  CAS  Google Scholar 

  30. Hanrahan V, Currie MJ, Gunningham SP, Morrin HR, Scott PA, Robinson BA, Fox SB (2003) J Pathol 200:183

    Article  CAS  Google Scholar 

  31. Klagsbrun M, D'Amore PA (1996) Cytokine Growth Factor Rev 7:259

    Article  CAS  Google Scholar 

  32. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999) Faseb J 13:9

    CAS  Google Scholar 

  33. Connolly DT, Olander JV, Heuvelman D, Nelson R, Monsell R, Siegel N, Haymore BL, Leimgruber R, Feder J (1989) J Biol Chem 264:20017

    CAS  Google Scholar 

  34. Ferrara N, Henzel WJ (1989) Biochem Biophys Res Commun 161:851

    Article  CAS  Google Scholar 

  35. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT (1989) Science 246:1309

    Article  CAS  Google Scholar 

  36. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N (1989) Science 246:1306

    Article  CAS  Google Scholar 

  37. Senger DR, Asch BB, Smith BD, Perruzzi CA, Dvorak HF (1983) Nature 302:714

    Article  CAS  Google Scholar 

  38. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW (1991) Mol Endocrinol 5:1806

    Article  CAS  Google Scholar 

  39. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA (1991) J Biol Chem 266:11947

    CAS  Google Scholar 

  40. Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, Vandlen R, Ferrara N (1996) J Biol Chem 271:7788

    Article  CAS  Google Scholar 

  41. Keyt BA, Nguyen HV, Berleau LT, Duarte CM, Park J, Chen H, Ferrara N (1996) J Biol Chem 271:5638

    Article  CAS  Google Scholar 

  42. Soker S, Gollamudi-Payne S, Fidder H, Charmahelli H, Klagsbrun M (1997) J Biol Chem 272:31582

    Article  CAS  Google Scholar 

  43. Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG (1991) Proc Natl Acad Sci USA 88:9267

    Article  CAS  Google Scholar 

  44. Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U (1996) Proc Natl Acad Sci USA 93:2576

    Article  CAS  Google Scholar 

  45. Nash AD, Baca M, Wright C, Scotney PD (2006) Pulm Pharmacol Ther 19:61

    Article  CAS  Google Scholar 

  46. Kukk E, Lymboussaki A, Taira S, Kaipainen A, Jeltsch M, Joukov V, Alitalo K (1996) Development 122:3829

    CAS  Google Scholar 

  47. Onogawa S, Kitadai Y, Tanaka S, Kuwai T, Kimura S, Chayama K (2004) Cancer Sci 95:32

    Article  CAS  Google Scholar 

  48. Li X, Eriksson U (2001) Int J Biochem Cell Biol 33:421

    Article  CAS  Google Scholar 

  49. Achen MG, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA (1998) Proc Natl Acad Sci USA 95:548

    Article  CAS  Google Scholar 

  50. Krishnan J, Kirkin V, Steffen A, Hegen M, Weih D, Tomarev S, Wilting J, Sleeman JP (2003) Cancer Res 63:713

    CAS  Google Scholar 

  51. Wong D, Luckhurst J, Toma H, Kuipers N, Loo S, Suarez A, Wilson JE, McManus BM (2001) J Heart Lung Transplant 20:156

    Article  Google Scholar 

  52. Yamada Y, Nezu J, Shimane M, Hirata Y (1997) Genomics 42:483

    Article  CAS  Google Scholar 

  53. Van Trappen PO, Steele D, Lowe DG, Baithun S, Beasley N, Thiele W, Weich H, Krishnan J, Shepherd JH, Pepper MS, Jackson DG, Sleeman JP, Jacobs IJ (2003) J Pathol 201:544

    Article  CAS  Google Scholar 

  54. Lyttle DJ, Fraser KM, Fleming SB, Mercer AA, Robinson AJ (1994) J Virol 68:84

    CAS  Google Scholar 

  55. Kiba A, Sagara H, Hara T, Shibuya M (2003) Biochem Biophys Res Commun 301:371

    Article  CAS  Google Scholar 

  56. Meyer M, Clauss M, Lepple-Wienhues A, Waltenberger J, Augustin HG, Ziche M, Lanz C, Buttner M, Rziha HJ, Dehio C (1999) Embo J 18:363

    Article  CAS  Google Scholar 

  57. Ogawa S, Oku A, Sawano A, Yamaguchi S, Yazaki Y, Shibuya M (1998) J Biol Chem 273:31273

    Article  CAS  Google Scholar 

  58. Shibuya M (2003) Cancer Sci 94:751

    Article  CAS  Google Scholar 

  59. Ferrara N, Gerber HP, LeCouter J (2003) Nat Med 9:669

    Article  CAS  Google Scholar 

  60. Robinson CJ, Stringer SE (2001) J Cell Sci 114:853

    CAS  Google Scholar 

  61. Barleon B, Siemeister G, Martiny-Baron G, Weindel K, Herzog C, Marme D (1997) Cancer Res 57:5421

    CAS  Google Scholar 

  62. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT (1992) Science 255:989

    Article  Google Scholar 

  63. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A (1993) Cell 72:835

    Article  CAS  Google Scholar 

  64. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P (1992) Biochem Biophys Res Commun 187:1579

    Article  CAS  Google Scholar 

  65. Lenton K (2002) J Biol Regul Homeost Agents 16:227

    CAS  Google Scholar 

  66. Meyer RD, Rahimi N (2003) Ann NY Acad Sci 995:200

    Article  CAS  Google Scholar 

  67. Birnbaum D (1995) Jpn J Cancer Res 86:inside cover

    Google Scholar 

  68. Terman B, Khandke L, Dougher-Vermazan M, Maglione D, Lassam NJ, Gospodarowicz D, Persico MG, Bohlen P, Eisinger M (1994) Growth Factors 11:187

    Article  CAS  Google Scholar 

  69. Wang D, Donner DB, Warren RS (2000) J Biol Chem 275:15905

    Article  CAS  Google Scholar 

  70. Rahimi N (2006) Front Biosci 11:818

    Article  CAS  Google Scholar 

  71. Peters KG, De Vries C, Williams LT (1993) Proc Natl Acad Sci USA 90:8915

    Article  CAS  Google Scholar 

  72. Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT (1993) Proc Natl Acad Sci USA 90:7533

    Article  CAS  Google Scholar 

  73. Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M (2000) Ann NY Acad Sci 902:201

    Article  CAS  Google Scholar 

  74. Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D (1993) Oncogene 8:1233

    CAS  Google Scholar 

  75. Kaipainen A, Korhonen J, Pajusola K, Aprelikova O, Persico MG, Terman BI, Alitalo K (1993) J Exp Med 178:2077

    Article  CAS  Google Scholar 

  76. Pajusola K, Aprelikova O, Korhonen J, Kaipainen A, Pertovaara L, Alitalo R, Alitalo K (1992) Cancer Res 52:5738

    CAS  Google Scholar 

  77. Andre T, Kotelevets L, Vaillant JC, Coudray AM, Weber L, Prevot S, Parc R, Gespach C, Chastre E (2000) Int J Cancer 86:174

    Article  CAS  Google Scholar 

  78. Hewett PW, Murray JC (1996) Biochem Biophys Res Commun 221:697

    Article  CAS  Google Scholar 

  79. Smith G, McLeod D, Foreman D, Boulton M (1999) Br J Ophthalmol 83:486

    Article  CAS  Google Scholar 

  80. Hughes DC (2001) J Mol Evol 53:77

    CAS  Google Scholar 

  81. Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K (1996) Embo J 15:290

    CAS  Google Scholar 

  82. Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (1996) Proc Natl Acad Sci USA 93:1988

    Article  CAS  Google Scholar 

  83. Wise LM, Veikkola T, Mercer AA, Savory LJ, Fleming SB, Caesar C, Vitali A, Makinen T, Alitalo K, Stacker SA (1999) Proc Natl Acad Sci USA 96:3071

    Article  CAS  Google Scholar 

  84. Romeo PH, Lemarchandel V, Tordjman R (2002) Adv Exp Med Biol 515:49

    Article  CAS  Google Scholar 

  85. Tordjman R, Lepelletier Y, Lemarchandel V, Cambot M, Gaulard P, Hermine O, Romeo PH (2002) Nat Immunol 3:477

    CAS  Google Scholar 

  86. Mamluk R, Gechtman Z, Kutcher ME, Gasiunas N, Gallagher J, Klagsbrun M (2002) J Biol Chem 277:24818

    Article  CAS  Google Scholar 

  87. Migdal M, Huppertz B, Tessler S, Comforti A, Shibuya M, Reich R, Baumann H, Neufeld G (1998) J Biol Chem 273:22272

    Article  CAS  Google Scholar 

  88. Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000) J Biol Chem 275:18040

    Article  CAS  Google Scholar 

  89. Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000) J Biol Chem 275:29922

    Article  CAS  Google Scholar 

  90. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (1998) Cell 92:735

    Article  CAS  Google Scholar 

  91. Neufeld G, Kessler O, Herzog Y (2002) Adv Exp Med Biol 515:81

    Article  CAS  Google Scholar 

  92. Kreuter M, Bielenberg D, Hida Y, Hida K, Klagsbrun M (2002) Ann Hematol 81(Suppl 2):S74

    Google Scholar 

  93. Nakamura F, Goshima Y (2002) Adv Exp Med Biol 515:55

    Article  CAS  Google Scholar 

  94. Neufeld G, Cohen T, Shraga N, Lange T, Kessler O, Herzog Y (2002) Trend Cardiovasc Med 12:13

    Article  CAS  Google Scholar 

  95. Ikeda M, Hosoda Y, Hirose S, Okada Y, Ikeda E (2000) J Pathol 191:426

    Article  CAS  Google Scholar 

  96. Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, Klagsbrun M (2000) Proc Natl Acad Sci USA 97:2573

    Article  CAS  Google Scholar 

  97. Lee P, Goishi K, Davidson AJ, Mannix R, Zon L, Klagsbrun M (2002) Proc Natl Acad Sci USA 99:10470

    Article  CAS  Google Scholar 

  98. Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y (2002) Proc Natl Acad Sci USA 99:383

    Article  CAS  Google Scholar 

  99. Whitaker GB, Limberg BJ, Rosenbaum JS (2001) J Biol Chem 276:25520

    Article  CAS  Google Scholar 

  100. Gill M, Dias S, Hattori K, Rivera ML, Hicklin D, Witte L, Girardi L, Yurt R, Himel H, Rafii S (2001) Circ Res 88:167

    Article  CAS  Google Scholar 

  101. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, Rafii S (2000) Blood 95:952

    CAS  Google Scholar 

  102. Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP (1997) N Engl J Med 337:1584

    Article  CAS  Google Scholar 

  103. Oberg C, Waltenberger J, Claesson-Welsh L, Welsh M (1994) Growth Factors 10:115

    Article  CAS  Google Scholar 

  104. Yang K, Cepko CL (1996) J Neurosci 16:6089

    CAS  Google Scholar 

  105. Katoh O, Tauchi H, Kawaishi K, Kimura A, Satow Y (1995) Cancer Res 55:5687

    CAS  Google Scholar 

  106. Brown LF, Detmar M, Tognazzi K, Abu-Jawdeh G, Iruela-Arispe ML (1997) Lab Invest 76:245

    CAS  Google Scholar 

  107. Hatva E, Kaipainen A, Mentula P, Jaaskelainen J, Paetau A, Haltia M, Alitalo K (1995) Am J Pathol 146:368

    CAS  Google Scholar 

  108. Boocock CA, Charnock-Jones DS, Sharkey AM, McLaren J, Barker PJ, Wright KA, Twentyman PR, Smith SK (1995) J Natl Cancer Inst 87:506

    Article  CAS  Google Scholar 

  109. Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A (1996) Nature 380:435

    Article  CAS  Google Scholar 

  110. Shalaby F, Ho J, Stanford WL, Fischer KD, Schuh AC, Schwartz L, Bernstein A, Rossant J (1997) Cell 89:981

    Article  CAS  Google Scholar 

  111. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC (1995) Nature 376:62

    Article  CAS  Google Scholar 

  112. Matthews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR (1991) Proc Natl Acad Sci USA 88:9026

    Article  CAS  Google Scholar 

  113. Cunningham SA, Stephan CC, Arrate MP, Ayer KG, Brock TA (1997) Biochem Biophys Res Commun 231:596

    Article  CAS  Google Scholar 

  114. Fuh G, Li B, Crowley C, Cunningham B, Wells JA (1998) J Biol Chem 273:11197

    Article  CAS  Google Scholar 

  115. Lu D, Kussie P, Pytowski B, Persaud K, Bohlen P, Witte L, Zhu Z (2000) J Biol Chem 275:14321

    Article  CAS  Google Scholar 

  116. Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, de Vos AM (1997) Proc Natl Acad Sci USA 94:7192

    Article  CAS  Google Scholar 

  117. Shinkai A, Ito M, Anazawa H, Yamaguchi S, Shitara K, Shibuya M (1998) J Biol Chem 273:31283

    Article  CAS  Google Scholar 

  118. Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM (1997) Cell 91:695

    Article  CAS  Google Scholar 

  119. Kroll J, Waltenberger J (1997) J Biol Chem 272:32521

    Article  CAS  Google Scholar 

  120. Seetharam L, Gotoh N, Maru Y, Neufeld G, Yamaguchi S, Shibuya M (1995) Oncogene 10:135

    CAS  Google Scholar 

  121. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH (1994) J Biol Chem 269:26988

    CAS  Google Scholar 

  122. Ito N, Wernstedt C, Engstrom U, Claesson-Welsh L (1998) J Biol Chem 273:23410

    Article  CAS  Google Scholar 

  123. Abedi H, Zachary I (1997) J Biol Chem 272:15442

    Article  CAS  Google Scholar 

  124. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N (1998) J Biol Chem 273:30336

    Article  CAS  Google Scholar 

  125. Guo D, Jia Q, Song HY, Warren RS, Donner DB (1995) J Biol Chem 270:6729

    Article  CAS  Google Scholar 

  126. Takahashi T, Shibuya M (1997) Oncogene 14:2079

    Article  CAS  Google Scholar 

  127. Rousseau S, Houle F, Kotanides H, Witte L, Waltenberger J, Landry J, Huot J (2000) J Biol Chem 275:10661

    Article  CAS  Google Scholar 

  128. Warner AJ, Lopez-Dee J, Knight EL, Feramisco JR, Prigent SA (2000) Biochem J 347:501

    Article  CAS  Google Scholar 

  129. Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB (2000) J Biol Chem 275:6059

    Article  CAS  Google Scholar 

  130. Takahashi N, Seko Y, Noiri E, Tobe K, Kadowaki T, Sabe H, Yazaki Y (1999) Circ Res 84:1194

    Article  CAS  Google Scholar 

  131. Takahashi T, Shibuya M (2001) Biochem Biophys Res Commun 280:415

    Article  CAS  Google Scholar 

  132. Takahashi T, Ueno H, Shibuya M (1999) Oncogene 18:2221

    Article  CAS  Google Scholar 

  133. Takahashi T, Yamaguchi S, Chida K, Shibuya M (2001) Embo J 20:2768

    Article  CAS  Google Scholar 

  134. Eliceiri BP, Paul R, Schwartzberg PL, Hood JD, Leng J, Cheresh DA (1999) Mol Cell 4:915

    Article  CAS  Google Scholar 

  135. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA (2002) J Cell Biol 157:149

    Article  CAS  Google Scholar 

  136. Igarashi K, Isohara T, Kato T, Takigawa K, Shigeta K, Yamano T, Uno II (1998) Int J Mol Med 2:211

    CAS  Google Scholar 

  137. Igarashi K, Shigeta K, Isohara T, Yamano T, Uno I (1998) Biochem Biophys Res Commun 251:77

    Article  CAS  Google Scholar 

  138. Dimmeler S, Dernbach E, Zeiher AM (2000) FEBS Lett 477:258

    Article  CAS  Google Scholar 

  139. Gliki G, Abu-Ghazaleh R, Jezequel S, Wheeler-Jones C, Zachary I (2001) Biochem J 353:503

    Article  CAS  Google Scholar 

  140. Hood J, Granger HJ (1998) J Biol Chem 273:23504

    Article  CAS  Google Scholar 

  141. Zachary I, Gliki G (2001) Cardiovasc Res 49:568

    Article  CAS  Google Scholar 

  142. Gille H, Kowalski J, Li B, LeCouter J, Moffat B, Zioncheck TF, Pelletier N, Ferrara N (2001) J Biol Chem 276:3222

    Article  CAS  Google Scholar 

  143. Li B, Fuh G, Meng G, Xin X, Gerritsen ME, Cunningham B, de Vos AM (2000) J Biol Chem 275:29823

    Article  CAS  Google Scholar 

  144. Larrivee B, Karsan A (2000) Int J Mol Med 5:447

    CAS  Google Scholar 

  145. Brown LF, Berse B, Jackman RW, Tognazzi K, Guidi AJ, Dvorak HF, Senger DR, Connolly JL, Schnitt SJ (1995) Hum Pathol 26:86

    Article  CAS  Google Scholar 

  146. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Dvorak HF, Senger DR (1993) Am J Pathol 143:1255

    CAS  Google Scholar 

  147. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF (1993) Cancer Res 53:4727

    CAS  Google Scholar 

  148. Brown LF, Berse B, Tognazzi K, Manseau EJ, Van de Water L, Senger DR, Dvorak HF, Rosen S (1992) Kidney Int 42:1457

    Article  CAS  Google Scholar 

  149. Brown LF, Harrist TJ, Yeo KT, Stahle-Backdahl M, Jackman RW, Berse B, Tognazzi K, Dvorak HF, Detmar M (1995) J Invest Dermatol 104:744

    Article  CAS  Google Scholar 

  150. Brown LF, Tognazzi K, Dvorak HF, Harrist TJ (1996) Am J Pathol 148:1065

    CAS  Google Scholar 

  151. Guidi AJ, Abu-Jawdeh G, Berse B, Jackman RW, Tognazzi K, Dvorak HF, Brown LF (1995) J Natl Cancer Inst 87:1237

    Article  CAS  Google Scholar 

  152. Guidi AJ, Abu-Jawdeh G, Tognazzi K, Dvorak HF, Brown LF (1996) Cancer 78:454

    Article  CAS  Google Scholar 

  153. Guidi AJ, Schnitt SJ, Fischer L, Tognazzi K, Harris JR, Dvorak HF, Brown LF (1997) Cancer 80:1945

    Article  CAS  Google Scholar 

  154. Olson TA, Mohanraj D, Carson LF, Ramakrishnan S (1994) Cancer Res 54:276

    CAS  Google Scholar 

  155. Plate KH, Breier G, Millauer B, Ullrich A, Risau W (1993) Cancer Res 53:5822

    CAS  Google Scholar 

  156. Wang ES, Teruya-Feldstein J, Wu Y, Zhu Z, Hicklin DJ, Moore MA (2004) Blood 104:2893

    Article  CAS  Google Scholar 

  157. Dias S, Hattori K, Zhu Z, Heissig B, Choy M, Lane W, Wu Y, Chadburn A, Hyjek E, Gill M, Hicklin DJ, Witte L, Moore MA, Rafii S (2000) J Clin Invest 106:511

    Article  CAS  Google Scholar 

  158. Wizigmann-Voos S, Breier G, Risau W, Plate KH (1995) Cancer Res 55:1358

    CAS  Google Scholar 

  159. Barnhill RL, Fandrey K, Levy MA, Mihm MC Jr, Hyman B (1992) Lab Invest 67:331

    CAS  Google Scholar 

  160. Barnhill RL, Piepkorn MW, Cochran AJ, Flynn E, Karaoli T, Folkman J (1998) Arch Dermatol 134:991

    Article  CAS  Google Scholar 

  161. Gasparini G, Barbareschi M, Boracchi P, Verderio P, Caffo O, Meli S, Palma PD, Marubini E, Bevilacqua P (1995) Cancer J Sci Am 1:131

    CAS  Google Scholar 

  162. Gasparini G, Harris AL (1995) J Clin Oncol 13:765

    CAS  Google Scholar 

  163. Gasparini G, Toi M, Verderio P, Ranieri G, Dante S, Bonoldi E, Boracchi P, Fanelli M, Tominaga T (1998) Int J Oncol 12:1117

    CAS  Google Scholar 

  164. Gasparini G, Weidner N, Maluta S, Pozza F, Boracchi P, Mezzetti M, Testolin A, Bevilacqua P (1993) Int J Cancer 55:739

    Article  CAS  Google Scholar 

  165. Lindmark G, Gerdin B, Pahlman L, Bergstrom R, Glimelius B (1994) Dis Colon Rectum 37:1219

    Article  CAS  Google Scholar 

  166. Lindmark G, Gerdin B, Sundberg C, Pahlman L, Bergstrom R, Glimelius B (1996) J Clin Oncol 14:461

    CAS  Google Scholar 

  167. Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA (1992) Lancet 340:145

    Article  CAS  Google Scholar 

  168. Olivarez D, Ulbright T, DeRiese W, Foster R, Reister T, Einhorn L, Sledge G (1994) Cancer Res 54:2800

    CAS  Google Scholar 

  169. Tanigawa N, Amaya H, Matsumura M, Shimomatsuya T, Horiuchi T, Muraoka R, Iki M (1996) Cancer Res 56:2671

    CAS  Google Scholar 

  170. Tanigawa N, Matsumura M, Amaya H, Kitaoka A, Shimomatsuya T, Lu C, Muraoka R, Tanaka T (1997) Cancer 79:220

    Article  CAS  Google Scholar 

  171. Weidner N, Carroll PR, Flax J, Blumenfeld W, Folkman J (1993) Am J Pathol 143:401

    CAS  Google Scholar 

  172. Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred EN, Moore DH, Meli S, Gasparini G (1992) J Natl Cancer Inst 84:1875

    Article  CAS  Google Scholar 

  173. Fong GH, Rossant J, Gertsenstein M, Breitman ML (1995) Nature 376:66

    Article  CAS  Google Scholar 

  174. Hicklin DJ, Witte L, Zhu Z, Liao F, Wu Y, Li Y, Bohlen P (2001) Drug Discov Today 6:517

    Article  CAS  Google Scholar 

  175. Lu D, Jimenez X, Zhang H, Bohlen P, Witte L, Zhu Z (2002) Int J Cancer 97:393

    Article  CAS  Google Scholar 

  176. Lu D, Shen J, Vil MD, Zhang H, Jimenez X, Bohlen P, Witte L, Zhu Z (2003) J Biol Chem 278:43496

    Article  CAS  Google Scholar 

  177. Posey JA, Ng TC, Yang B, Khazaeli MB, Carpenter MD, Fox F, Needle M, Waksal H, LoBuglio AF (2003) Clin Cancer Res 9:1323

    CAS  Google Scholar 

  178. Watanabe H, Mamelak AJ, Wang B, Howell BG, Freed I, Esche C, Nakayama M, Nagasaki G, Hicklin DJ, Kerbel RS, Sauder DN (2004) Exp Dermatol 13:671

    Article  CAS  Google Scholar 

  179. Zhu Z, Hattori K, Zhang H, Jimenez X, Ludwig DL, Dias S, Kussie P, Koo H, Kim HJ, Lu D, Liu M, Tejada R, Friedrich M, Bohlen P, Witte L, Rafii S (2003) Leukemia 17:604

    Article  CAS  Google Scholar 

  180. Boyer SJ (2002) Curr Top Med Chem 2:973

    Article  CAS  Google Scholar 

  181. Ciardiello F, Bianco R, Caputo R, Caputo R, Damiano V, Troiani T, Melisi D, De Vita F, De Placido S, Bianco AR, Tortora G (2004) Clin Cancer Res 10:784

    Article  CAS  Google Scholar 

  182. Drevs J, Muller-Driver R, Wittig C, Fuxius S, Esser N, Hugenschmidt H, Konerding MA, Allegrini PR, Wood J, Hennig J, Unger C, Marme D (2002) Cancer Res 62:4015

    CAS  Google Scholar 

  183. Fraley ME, Hoffman WF, Arrington KL, Hungate RW, Hartman GD, McFall RC, Coll KE, Rickert K, Thomas KA, McGaughey GB (2004) Curr Med Chem 11:709

    Article  CAS  Google Scholar 

  184. Gingrich DE, Reddy DR, Iqbal MA, Singh J, Aimone LD, Angeles TS, Albom M, Yang S, Ator MA, Meyer SL, Robinson C, Ruggeri BA, Dionne CA, Vaught JL, Mallamo JP, Hudkins RL (2003) J Med Chem 46:5375

    Article  CAS  Google Scholar 

  185. Laird AD, Cherrington JM (2003) Expert Opin Investig Drugs 12:51

    Article  CAS  Google Scholar 

  186. Shawver LK, Slamon D, Ullrich A (2002) Cancer Cell 1:117

    Article  CAS  Google Scholar 

  187. Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, Meyer T, Tang C, Wartmann M, Wood J, Caravatti G (2004) Cancer Res 64:4931

    Article  CAS  Google Scholar 

  188. Fiedler W, Graeven U, Ergun S, Verago S, Kilic N, Stockschlader M, Hossfeld DK (1997) Blood 89:1870

    CAS  Google Scholar 

  189. Graeven U, Fiedler W, Karpinski S, Ergun S, Kilic N, Rodeck U, Schmiegel W, Hossfeld DK (1999) J Cancer Res Clin Oncol 125:621

    Article  CAS  Google Scholar 

  190. Ratajczak MZ, Ratajczak J, Machalinski B, Majka M, Marlicz W, Carter A, Pietrzkowski Z, Gewirtz AM (1998) Br J Haematol 103:969

    Article  CAS  Google Scholar 

  191. Dias S, Hattori K, Heissig B, Zhu Z, Wu Y, Witte L, Hicklin DJ, Tateno M, Bohlen P, Moore MA, Rafii S (2001) Proc Natl Acad Sci USA 98:10857

    Article  CAS  Google Scholar 

  192. Zhang H, Li Y, Li H, Bassi R, Jimenez X, Witte L, Bohlen P, Hicklin D, Zhu Z (2004) Leuk Lymphoma 45:1887

    Article  CAS  Google Scholar 

  193. Ria R, Vacca A, Russo F, Cirulli T, Massaia M, Tosi P, Cavo M, Guidolin D, Ribatti D, Dammacco F (2004) Thromb Haemost 92:1438

    CAS  Google Scholar 

  194. Rockwell P, Neufeld G, Glassman A, Caron D, Goldstein N (1995) Mol Cell Differ 3:91

    CAS  Google Scholar 

  195. Prewett M, Huber J, Li Y, Santiago A, O'Connor W, King K, Overholser J, Hooper A, Pytowski B, Witte L, Bohlen P, Hicklin DJ (1999) Cancer Res 59:5209

    CAS  Google Scholar 

  196. Paz K, Zhu Z (2005) Front Biosci 10:1415

    Article  CAS  Google Scholar 

  197. Zhu Z, Witte L (1999) Invest New Drugs 17:195

    Article  CAS  Google Scholar 

  198. Witte L, Hicklin DJ, Zhu Z, Pytowski B, Kotanides H, Rockwell P, Bohlen P (1998) Cancer Metastasis Rev 17:155

    Article  CAS  Google Scholar 

  199. Bruns CJ, Shrader M, Harbison MT, Portera C, Solorzano CC, Jauch KW, Hicklin DJ, Radinsky R, Ellis LM (2002) Int J Cancer 102:101

    Article  CAS  Google Scholar 

  200. Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD (2001) Cancer Res 61:39

    CAS  Google Scholar 

  201. Sweeney P, Karashima T, Kim SJ, Kedar D, Mian B, Huang S, Baker C, Fan Z, Hicklin DJ, Pettaway CA, Dinney CP (2002) Clin Cancer Res 8:2714

    CAS  Google Scholar 

  202. Zimmermann RC, Hartman T, Bohlen P, Sauer MV, Kitajewski J (2001) Microvasc Res 62:15

    Article  CAS  Google Scholar 

  203. Pauli SA, Tang H, Wang J, Bohlen P, Posser R, Hartman T, Sauer MV, Kitajewski J, Zimmermann RC (2005) Endocrinology 146:1301

    Article  CAS  Google Scholar 

  204. Manley PW, Bold G, Bruggen J, Fendrich G, Furet P, Mestan J, Schnell C, Stolz B, Meyer T, Meyhack B, Stark W, Strauss A, Wood J (2004) Biochim Biophys Acta 1697:17

    Article  CAS  Google Scholar 

  205. Hunt S (2001) Curr Opin Mol Ther 3:418

    CAS  Google Scholar 

  206. Zhu Z, Rockwell P, Lu D, Kotanides H, Pytowski B, Hicklin DJ, Bohlen P, Witte L (1998) Cancer Res 58:3209

    CAS  Google Scholar 

  207. Zhu Z, Lu D, Kotanides H, Santiago A, Jimenez X, Simcox T, Hicklin DJ, Bohlen P, Witte L (1999) Cancer Lett 136:203

    Article  CAS  Google Scholar 

  208. McLeod DS, Taomoto M, Cao J, Zhu Z, Witte L, Lutty GA (2002) Invest Ophthalmol Vis Sci 43:474

    Google Scholar 

  209. Traxler P, Bold G, Buchdunger E, Caravatti G, Furet P, Manley P, O'Reilly T, Wood J, Zimmermann J (2001) Med Res Rev 21:499

    Article  CAS  Google Scholar 

  210. Underiner TL, Ruggeri B, Gingrich DE (2004) Curr Med Chem 11:731

    Article  CAS  Google Scholar 

  211. Bayes M, Rabasseda X, Prous JR (2003) Methods Find Exp Clin Pharmacol 25:483

    CAS  Google Scholar 

  212. Motzer RJ, Hoosen S, Bello CL, Christensen JG (2006) Expert Opin Investig Drugs 15:553

    Article  CAS  Google Scholar 

  213. Ryan AJ, Wedge SR (2005) Br J Cancer 92(Suppl 1):S6

    Article  CAS  Google Scholar 

  214. Hannah AL (2005) Curr Mol Med 5:625

    Article  CAS  Google Scholar 

  215. Sridhar SS, Shepherd FA (2003) Lung Cancer 42(Suppl 1):S81

    Article  Google Scholar 

  216. Antonian L, Zhang H, Yang C, Wagner G, Shawver LK, Shet M, Ogilvie B, Madan A, Parkinson A (2000) Drug Metab Dispos 28:1505

    CAS  Google Scholar 

  217. Bischof M, Abdollahi A, Gong P, Stoffregen C, Lipson KE, Debus JU, Weber KJ, Huber PE (2004) Int J Radiat Oncol Biol Phys 60:1220

    Article  CAS  Google Scholar 

  218. Haspel HC, Scicli GM, McMahon G, Scicli AG (2002) Microvasc Res 63:304

    Article  CAS  Google Scholar 

  219. Huss WJ, Barrios RJ, Greenberg NM (2003) Mol Cancer Ther 2:611

    CAS  Google Scholar 

  220. Mendel DB, Laird AD, Smolich BD, Blake RA, Liang C, Hannah AL, Shaheen RM, Ellis LM, Weitman S, Shawver LK, Cherrington JM (2000) Anticancer Drug Des 15:29

    CAS  Google Scholar 

  221. Vajkoczy P, Menger MD, Vollmar B, Schilling L, Schmiedek P, Hirth KP, Ullrich A, Fong TA (1999) Neoplasia 1:31

    Article  CAS  Google Scholar 

  222. Zhao Y, Yang CY, Haznedar J, Antonian L (2001) J Pharm Biomed Anal 25:821

    Article  CAS  Google Scholar 

  223. Giles FJ, Stopeck AT, Silverman LR, Lancet JE, Cooper MA, Hannah AL, Cherrington JM, O'Farrell AM, Yuen HA, Louie SG, Hong W, Cortes JE, Verstovsek S, Albitar M, O'Brien SM, Kantarjian HM, Karp JE (2003) Blood 102:795

    Article  CAS  Google Scholar 

  224. Kuenen BC, Rosen L, Smit EF, Parson MR, Levi M, Ruijter R, Huisman H, Kedde MA, Noordhuis P, van der Vijgh WJ, Peters GJ, Cropp GF, Scigalla P, Hoekman K, Pinedo HM, Giaccone G (2002) J Clin Oncol 20:1657

    Article  CAS  Google Scholar 

  225. Stopeck A, Sheldon M, Vahedian M, Cropp G, Gosalia R, Hannah A (2002) Clin Cancer Res 8:2798

    CAS  Google Scholar 

  226. Dowlati A, Robertson K, Radivoyevitch T, Waas J, Ziats NP, Hartman P, Abdul-Karim FW, Wasman JK, Jesberger J, Lewin J, McCrae K, Ivy P, Remick SC (2005) Clin Cancer Res 11:7938

    Article  CAS  Google Scholar 

  227. O'Donnell A, Padhani A, Hayes C, Kakkar AJ, Leach M, Trigo JM, Scurr M, Raynaud F, Phillips S, Aherne W, Hardcastle A, Workman P, Hannah A, Judson I (2005) Br J Cancer 93:876

    Article  CAS  Google Scholar 

  228. Hoff PM, Wolff RA, Bogaard K, Waldrum S, Abbruzzese JL (2006) Jpn J Clin Oncol 36:100

    Article  Google Scholar 

  229. Salzberg M, Pless M, Rochlitz C, Ambrus K, Scigalla P, Herrmann R (2006) Invest New Drugs 24:299

    Article  Google Scholar 

  230. Fiedler W, Mesters R, Tinnefeld H, Loges S, Staib P, Duhrsen U, Flasshove M, Ottmann OG, Jung W, Cavalli F, Kuse R, Thomalla J, Serve H, O'Farrell AM, Jacobs M, Brega NM, Scigalla P, Hossfeld DK, Berdel WE (2003) Blood 102:2763

    Article  CAS  Google Scholar 

  231. Giles FJ, Cooper MA, Silverman L, Karp JE, Lancet JE, Zangari M, Shami PJ, Khan KD, Hannah AL, Cherrington JM, Thomas DA, Garcia-Manero G, Albitar M, Kantarjian HM, Stopeck AT (2003) Cancer 97:1920

    Article  CAS  Google Scholar 

  232. Heymach JV, Desai J, Manola J, Davis DW, McConkey DJ, Harmon D, Ryan DP, Goss G, Quigley T, Van den Abbeele AD, Silverman SG, Connors S, Folkman J, Fletcher CD, Demetri GD (2004) Clin Cancer Res 10:5732

    Article  CAS  Google Scholar 

  233. Mesters RM, Padro T, Bieker R, Steins M, Kreuter M, Goner M, Kelsey S, Scigalla P, Fiedler W, Buchner T, Berdel WE (2001) Blood 98:241

    Article  CAS  Google Scholar 

  234. Peterson AC, Swiger S, Stadler WM, Medved M, Karczmar G, Gajewski TF (2004) Clin Cancer Res 10:4048

    Article  CAS  Google Scholar 

  235. Stadler WM, Cao D, Vogelzang NJ, Ryan CW, Hoving K, Wright R, Karrison T, Vokes EE (2004) Clin Cancer Res 10:3365

    Article  CAS  Google Scholar 

  236. Zangari M, Anaissie E, Stopeck A, Morimoto A, Tan N, Lancet J, Cooper M, Hannah A, Garcia-Manero G, Faderl S, Kantarjian H, Cherrington J, Albitar M, Giles FJ (2004) Clin Cancer Res 10:88

    Article  CAS  Google Scholar 

  237. Fury MG, Zahalsky A, Wong R, Venkatraman E, Lis E, Hann L, Aliff T, Gerald W, Fleisher M, Pfister DG (2006) Invest New Drugs (published online 19 Sept 2006)

    Google Scholar 

  238. Anon (2002) Expert Rev Anticancer Ther 2:5

    Article  Google Scholar 

  239. Laird AD, Christensen JG, Li G, Carver J, Smith K, Xin X, Moss KG, Louie SG, Mendel DB, Cherrington JM (2002) Faseb J 16:681

    CAS  Google Scholar 

  240. Laird AD, Vajkoczy P, Shawver LK, Thurnher A, Liang C, Mohammadi M, Schlessinger J, Ullrich A, Hubbard SR, Blake RA, Fong TA, Strawn LM, Sun L, Tang C, Hawtin R, Tang F, Shenoy N, Hirth KP, McMahon G, Cherrington JM (2000) Cancer Res 60:4152

    CAS  Google Scholar 

  241. Hoekman K (2001) Cancer J 7(Suppl 3):S134

    Google Scholar 

  242. Shaheen RM, Davis DW, Liu W, Zebrowski BK, Wilson MR, Bucana CD, McConkey DJ, McMahon G, Ellis LM (1999) Cancer Res 59:5412

    CAS  Google Scholar 

  243. Kim DW, Jo YS, Jung HS, Chung HK, Song JH, Park KC, Park SH, Hwang JH, Rha SY, Kweon GR, Lee SJ, Jo KW, Shong M (2006) J Clin Endocrinol Metab 91(10):4070

    Article  CAS  Google Scholar 

  244. Tokuyama J, Kubota T, Saikawa Y, Yoshida M, Furukawa T, Otani Y, Kumai K, Kitajima M (2005) Anticancer Res 25:17

    CAS  Google Scholar 

  245. Kuenen BC, Giaccone G, Ruijter R, Kok A, Schalkwijk C, Hoekman K, Pinedo HM (2005) Clin Cancer Res 11:6240

    Article  CAS  Google Scholar 

  246. Lu B, Geng L, Musiek A, Tan J, Cao C, Donnelly E, McMahon G, Choy H, Hallahan DE (2004) Int J Radiat Oncol Biol Phys 58:844

    Article  CAS  Google Scholar 

  247. Nakamura T, Ozawa S, Kitagawa Y, Ueda M, Kubota T, Kitajima M (2006) Oncol Rep 15:79

    CAS  Google Scholar 

  248. Jiang XT, Tao HQ, Zou SC (2006) Zhonghua Wei Chang Wai Ke Za Zhi 9:335

    Google Scholar 

  249. Zhou Q, Olivo M, Lye KY, Moore S, Sharma A, Chowbay B (2005) Cancer Chemother Pharmacol 56:569

    Article  CAS  Google Scholar 

  250. Yorozuya K, Kubota T, Watanabe M, Hasegawa H, Ozawa S, Kitajima M, Chikahisa LM, Yamada Y (2005) Oncol Rep 14:677

    CAS  Google Scholar 

  251. Marzola P, Degrassi A, Calderan L, Farace P, Crescimanno C, Nicolato E, Giusti A, Pesenti E, Terron A, Sbarbati A, Abrams T, Murray L, Osculati F (2004) Clin Cancer Res 10:739

    Article  CAS  Google Scholar 

  252. Garofalo A, Naumova E, Manenti L, Ghilardi C, Ghisleni G, Caniatti M, Colombo T, Cherrington JM, Scanziani E, Nicoletti MI, Giavazzi R (2003) Clin Cancer Res 9:3476

    CAS  Google Scholar 

  253. Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, Huber PE (2003) Cancer Res 63:3755

    CAS  Google Scholar 

  254. Xiong HQ, Herbst R, Faria SC, Scholz C, Davis D, Jackson EF, Madden T, McConkey D, Hicks M, Hess K, Charnsangavej CA, Abbruzzese JL (2004) Invest New Drugs 22:459

    Article  CAS  Google Scholar 

  255. Sistla A, Sunga A, Phung K, Koparkar A, Shenoy N (2004) Drug Dev Ind Pharm 30:19

    Article  CAS  Google Scholar 

  256. Takahashi H, Obata R, Tamaki Y (2006) J Ocul Pharmacol Ther 22:213

    Article  CAS  Google Scholar 

  257. Faivre S, Delbaldo C, Vera K, Robert C, Lozahic S, Lassau N, Bello C, Deprimo S, Brega N, Massimini G, Armand JP, Scigalla P, Raymond E (2006) J Clin Oncol 24:25

    Article  CAS  Google Scholar 

  258. Cabebe E, Wakelee H (2006) Drugs Today (Barc) 42:387

    Article  CAS  Google Scholar 

  259. Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM (2003) Mol Cancer Ther 2:471

    CAS  Google Scholar 

  260. Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q (2004) J Chromatogr A 1024:87

    Article  CAS  Google Scholar 

  261. Bayes M, Rabasseda X, Prous JR (2004) Methods Find Exp Clin Pharmacol 26:473

    CAS  Google Scholar 

  262. Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM (2003) Clin Cancer Res 9:327

    CAS  Google Scholar 

  263. O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM (2003) Blood 101:3597

    Article  CAS  Google Scholar 

  264. Sun L, Liang C, Shirazian S, Zhou Y, Miller T, Cui J, Fukuda JY, Chu JY, Nematalla A, Wang X, Chen H, Sistla A, Luu TC, Tang F, Wei J, Tang C (2003) J Med Chem 46:1116

    Article  CAS  Google Scholar 

  265. von Mehren M (2003) Curr Treat Options Oncol 4:441

    Article  Google Scholar 

  266. Abrams TJ, Murray LJ, Pesenti E, Holway VW, Colombo T, Lee LB, Cherrington JM, Pryer NK (2003) Mol Cancer Ther 2:1011

    CAS  Google Scholar 

  267. Morimoto AM, Tan N, West K, McArthur G, Toner GC, Manning WC, Smolich BD, Cherrington JM (2004) Oncogene 23:1618

    Article  CAS  Google Scholar 

  268. Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE (2003) Cancer Res 63:4009

    CAS  Google Scholar 

  269. Bello CL, Sherman L, Zhou J, Verkh L, Smeraglia J, Mount J, Klamerus KJ (2006) Anticancer Drugs 17:353

    Article  CAS  Google Scholar 

  270. Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O'Farrell AM, Bello CL, Allred R, Manning WC, Cherrington JM, Louie SG, Hong W, Brega NM, Massimini G, Scigalla P, Berdel WE, Hossfeld DK (2005) Blood 105:986

    Article  CAS  Google Scholar 

  271. O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM (2003) Clin Cancer Res 9:5465

    Google Scholar 

  272. Prenen H, Cools J, Mentens N, Folens C, Sciot R, Schoffski P, Van Oosterom A, Marynen P, Debiec-Rychter M (2006) Clin Cancer Res 12:2622

    Article  CAS  Google Scholar 

  273. Bold G, Altmann KH, Frei J, Lang M, Manley PW, Traxler P, Wietfeld B, Bruggen J, Buchdunger E, Cozens R, Ferrari S, Furet P, Hofmann F, Martiny-Baron G, Mestan J, Rosel J, Sills M, Stover D, Acemoglu F, Boss E, Emmenegger R, Lasser L, Masso E, Roth R, Schlachter C, Vetterli W (2000) J Med Chem 43:2310

    Article  CAS  Google Scholar 

  274. Drevs J, Hofmann I, Hugenschmidt H, Wittig C, Madjar H, Muller M, Wood J, Martiny-Baron G, Unger C, Marme D (2000) Cancer Res 60:4819

    CAS  Google Scholar 

  275. Furet P, Bold G, Hofmann F, Manley P, Meyer T, Altmann KH (2003) Bioorg Med Chem Lett 13:2967

    Article  CAS  Google Scholar 

  276. Morgan B, Thomas AL, Drevs J, Hennig J, Buchert M, Jivan A, Horsfield MA, Mross K, Ball HA, Lee L, Mietlowski W, Fuxuis S, Unger C, O'Byrne K, Henry A, Cherryman GR, Laurent D, Dugan M, Marme D, Steward WP (2003) J Clin Oncol 21:3955

    Article  CAS  Google Scholar 

  277. Thomas AL, Morgan B, Drevs J, Unger C, Wiedenmann B, Vanhoefer U, Laurent D, Dugan M, Steward WP (2003) Semin Oncol 30:32

    CAS  Google Scholar 

  278. Jost L, Gschwind HP, Jalava T, Wang Y, Guenther C, Souppart C, Rottmann A, Denner K, Waldmeier F, Gross G, Masson E, Laurent D (2006) Drug Metab Dispos 34:1817

    Article  CAS  Google Scholar 

  279. Tyagi P (2005) Clin Colorectal Cancer 5:24

    Article  Google Scholar 

  280. Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rosel J, Schnell C, Stover D, Theuer A, Towbin H, Wenger F, Woods-Cook K, Menrad A, Siemeister G, Schirner M, Thierauch KH, Schneider MR, Drevs J, Martiny-Baron G, Totzke F (2000) Cancer Res 60:2178

    CAS  Google Scholar 

  281. Gourley M, Williamson JS (2000) Curr Pharm Des 6:417

    Article  CAS  Google Scholar 

  282. Thomas AL, Morgan B, Horsfield MA, Higginson A, Kay A, Lee L, Masson E, Puccio-Pick M, Laurent D, Steward WP (2005) J Clin Oncol 23:4162

    Article  CAS  Google Scholar 

  283. Hennequin LF, Stokes ES, Thomas AP, Johnstone C, Ple PA, Ogilvie DJ, Dukes M, Wedge SR, Kendrew J, Curwen JO (2002) J Med Chem 45:1300

    Article  CAS  Google Scholar 

  284. Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Curwen JO, Hennequin LF, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF (2000) Cancer Res 60:970

    CAS  Google Scholar 

  285. Checkley D, Tessier JJ, Wedge SR, Dukes M, Kendrew J, Curry B, Middleton B, Waterton JC (2003) Magn Reson Imaging 21:475

    Article  CAS  Google Scholar 

  286. Pradel C, Siauve N, Bruneteau G, Clement O, de Bazelaire C, Frouin F, Wedge SR, Tessier JL, Robert PH, Frija G, Cuenod CA (2003) Magn Reson Imaging 21:845

    Article  CAS  Google Scholar 

  287. Carlomagno F, Vitagliano D, Guida T, Ciardiello F, Tortora G, Vecchio G, Ryan AJ, Fontanini G, Fusco A, Santoro M (2002) Cancer Res 62:7284

    CAS  Google Scholar 

  288. Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Musgrove HL, Graham GA, Hughes GD, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF, Bigley AL, Hennequin LF (2002) Cancer Res 62:4645

    CAS  Google Scholar 

  289. McCarty MF, Wey J, Stoeltzing O, Liu W, Fan F, Bucana C, Mansfield PF, Ryan AJ, Ellis LM (2004) Mol Cancer Ther 3:1041

    CAS  Google Scholar 

  290. Sandstrom M, Johansson M, Andersson U, Bergh A, Bergenheim AT, Henriksson R (2004) Br J Cancer 91:1174

    CAS  Google Scholar 

  291. Ciardiello F, Caputo R, Damiano V, Caputo R, Troiani T, Vitagliano D, Carlomagno F, Veneziani BM, Fontanini G, Bianco AR, Tortora G (2003) Clin Cancer Res 9:1546

    CAS  Google Scholar 

  292. Checkley D, Tessier JJ, Kendrew J, Waterton JC, Wedge SR (2003) Br J Cancer 89:1889

    Article  CAS  Google Scholar 

  293. Heffelfinger SC, Yan M, Gear RB, Schneider J, LaDow K, Warshawsky D (2004) Lab Invest 84:989

    Article  CAS  Google Scholar 

  294. Anon (1999) Drugs R D 1:135

    Article  Google Scholar 

  295. Gingras D, Labelle D, Nyalendo C, Boivin D, Demeule M, Barthomeuf C, Beliveau R (2004) Invest New Drugs 22:17

    Article  CAS  Google Scholar 

  296. Beliveau R, Gingras D, Kruger EA, Lamy S, Sirois P, Simard B, Sirois MG, Tranqui L, Baffert F, Beaulieu E, Dimitriadou V, Pepin MC, Courjal F, Ricard I, Poyet P, Falardeau P, Figg WD, Dupont E (2002) Clin Cancer Res 8:1242

    CAS  Google Scholar 

  297. Dupont E, Falardeau P, Mousa SA, Dimitriadou V, Pepin MC, Wang T, Alaoui-Jamali MA (2002) Clin Exp Metastasis 19:145

    Article  CAS  Google Scholar 

  298. Dupont E, Wang B, Mamelak AJ, Howell BG, Shivji G, Zhuang L, Dimitriadou V, Falardeau P, Sauder DN (2003) J Cutan Med Surg

    Google Scholar 

  299. Gingras D, Batist G, Beliveau R (2001) Expert Rev Anticancer Ther 1:341

    Article  CAS  Google Scholar 

  300. Gingras D, Boivin D, Deckers C, Gendron S, Barthomeuf C, Beliveau R (2003) Anticancer Drugs 14:91

    Article  CAS  Google Scholar 

  301. Boivin D, Gendron S, Beaulieu E, Gingras D, Beliveau R (2002) Mol Cancer Ther 1:795

    CAS  Google Scholar 

  302. Latreille J, Batist G, Laberge F, Champagne P, Croteau D, Falardeau P, Levinton C, Hariton C, Evans WK, Dupont E (2003) Clin Lung Cancer 4:231

    Article  CAS  Google Scholar 

  303. Shepherd FA (2001) Lung Cancer 34(Suppl 3):S81

    Article  Google Scholar 

  304. Sauder DN, Dekoven J, Champagne P, Croteau D, Dupont E (2002) J Am Acad Dermatol 47:535

    Article  Google Scholar 

  305. Anon (2001) Expert Rev Anticancer Ther 1:3

    Article  Google Scholar 

  306. Batist G, Patenaude F, Champagne P, Croteau D, Levinton C, Hariton C, Escudier B, Dupont E (2002) Ann Oncol 13:1259

    Article  CAS  Google Scholar 

  307. Weber MH, Lee J, Orr FW (2002) Int J Oncol 20:299

    CAS  Google Scholar 

  308. Dev IK, Dornsife RE, Hopper TM, Onori JA, Miller CG, Harrington LE, Dold KM, Mullin RJ, Johnson JH, Crosby RM, Truesdale AT, Epperly AH, Hinkle KW, Cheung M, Stafford JA, Luttrell DK, Kumar R (2004) Br J Cancer 91:1391

    Article  CAS  Google Scholar 

  309. Hutson TE, Bukowski RM (2006) Clin Genitourin Cancer 4:296

    Article  CAS  Google Scholar 

  310. Shi W, Siemann DW (2005) In Vivo 19:1045

    CAS  Google Scholar 

  311. Heymach JV (2005) Br J Cancer 92(Suppl 1):S14

    Article  CAS  Google Scholar 

  312. Zirrolli JA, Bradshaw EL, Long ME, Gustafson DL (2005) J Pharm Biomed Anal 39:705

    Article  CAS  Google Scholar 

  313. Tuccillo C, Romano M, Troiani T, Martinelli E, Morgillo F, De Vita F, Bianco R, Fontanini G, Bianco RA, Tortora G, Ciardiello F (2005) Clin Cancer Res 11:1268

    CAS  Google Scholar 

  314. Morgensztern D, Govindan R (2006) Expert Rev Anticancer Ther 6:545

    Article  CAS  Google Scholar 

  315. Lee D (2005) Clin Lung Cancer 7:89

    Article  Google Scholar 

  316. Rini BI (2005) Clin Genitourin Cancer 4:175

    Article  CAS  Google Scholar 

  317. Li KL, Wilmes LJ, Henry RG, Pallavicini MG, Park JW, Hu-Lowe DD, McShane TM, Shalinsky DR, Fu YJ, Brasch RC, Hylton NM (2005) J Magn Reson Imaging 22:511

    Article  CAS  Google Scholar 

  318. Rugo HS, Herbst RS, Liu G, Park JW, Kies MS, Steinfeldt HM, Pithavala YK, Reich SD, Freddo JL, Wilding G (2005) J Clin Oncol 23:5474

    Article  CAS  Google Scholar 

  319. Yigitbasi OG, Younes MN, Doan D, Jasser SA, Schiff BA, Bucana CD, Bekele BN, Fidler IJ, Myers JN (2004) Cancer Res 64:7977

    Article  CAS  Google Scholar 

  320. Lee SH, Lopes de Menezes D, Vora J, Harris A, Ye H, Nordahl L, Garrett E, Samara E, Aukerman SL, Gelb AB, Heise C (2005) Clin Cancer Res 11:3633

    Article  CAS  Google Scholar 

  321. Trudel S, Li ZH, Wei E, Wiesmann M, Chang H, Chen C, Reece D, Heise C, Stewart AK (2005) Blood 105:2941

    Article  CAS  Google Scholar 

  322. Ruggeri B, Singh J, Gingrich D, Angeles T, Albom M, Yang S, Chang H, Robinson C, Hunter K, Dobrzanski P, Jones-Bolin S, Pritchard S, Aimone L, Klein-Szanto A, Herbert JM, Bono F, Schaeffer P, Casellas P, Bourie B, Pili R, Isaacs J, Ator M, Hudkins R, Vaught J, Mallamo J, Dionne C (2003) Cancer Res 63:5978

    CAS  Google Scholar 

  323. Jones-Bolin S, Zhao H, Hunter K, Klein-Szanto A, Ruggeri B (2006) Mol Cancer Ther 5:1744

    Article  CAS  Google Scholar 

  324. Siemeister G, Luecking U, Wagner C, Detjen K, Mc Coy C, Bosslet K (2006) Biomed Pharmacother 60:269

    Article  CAS  Google Scholar 

  325. Fraley ME, Hoffman WF, Rubino RS, Hungate RW, Tebben AJ, Rutledge RZ, McFall RC, Huckle WR, Kendall RL, Coll KE, Thomas KA (2002) Bioorg Med Chem Lett 12:2767

    Article  CAS  Google Scholar 

  326. Manley PJ, Balitza AE, Bilodeau MT, Coll KE, Hartman GD, McFall RC, Rickert KW, Rodman LD, Thomas KA (2003) Bioorg Med Chem Lett 13:1673

    Article  CAS  Google Scholar 

  327. Anon (2002) Drugs R D 3:28

    Article  Google Scholar 

  328. Anon (2003) Clin Colorectal Cancer 3:85

    Article  Google Scholar 

  329. Anon (2004) Med Lett Drugs Ther 46:47

    Google Scholar 

  330. Ratner M (2004) Nat Biotechnol 22:1198

    Article  CAS  Google Scholar 

  331. Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS (2002) Proc Natl Acad Sci USA 99:11393

    Article  CAS  Google Scholar 

  332. Konner J, Dupont J (2004) Clin Colorectal Cancer 4(Suppl 2):S81

    Article  CAS  Google Scholar 

  333. Saishin Y, Saishin Y, Takahashi K, Lima e Silva R, Hylton D, Rudge JS, Wiegand SJ, Campochiaro PA (2003) J Cell Physiol 195:241

    Article  CAS  Google Scholar 

  334. Forster Y, Meye A, Krause S, Schwenzer B (2004) Cancer Lett 212:95

    Article  CAS  Google Scholar 

  335. He R, Liu B, Yang C, Yang RC, Tobelem G, Han ZC (2003) Cancer Gene Ther 10:879

    Article  CAS  Google Scholar 

  336. Ruan GR, Liu YR, Chen SS, Fu JY, Chang Y, Qin YZ, Li JL, Yu H, Wang H (2004) Leuk Res 28:763

    Article  CAS  Google Scholar 

  337. Jain RK (2002) Semin Oncol 29:3

    CAS  Google Scholar 

  338. Munn LL (2003) Drug Discov Today 8:396

    Article  Google Scholar 

  339. Boehm T, Folkman J, Browder T, O'Reilly MS (1997) Nature 390:404

    Article  CAS  Google Scholar 

  340. Geng L, Donnelly E, McMahon G, Lin PC, Sierra-Rivera E, Oshinka H, Hallahan DE (2001) Cancer Res 61:2413

    CAS  Google Scholar 

  341. Kerbel RS (1997) Nature 390:335

    Article  CAS  Google Scholar 

  342. Kerbel RS (2001) Cancer Metastasis Rev 20:1

    Article  CAS  Google Scholar 

  343. Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, Kerbel RS (2000) J Clin Invest 105:R15

    Article  CAS  Google Scholar 

  344. Klement G, Huang P, Mayer B, Green SK, Man S, Bohlen P, Hicklin D, Kerbel RS (2002) Clin Cancer Res 8:221

    CAS  Google Scholar 

  345. Yu JL, Rak JW, Coomber BL, Hicklin DJ, Kerbel RS (2002) Science 295:1526

    Article  CAS  Google Scholar 

  346. Jung YD, Mansfield PF, Akagi M, Takeda A, Liu W, Bucana CD, Hicklin DJ, Ellis LM (2002) Eur J Cancer 38:1133

    Article  CAS  Google Scholar 

  347. Huang X, Molema G, King S, Watkins L, Edgington TS, Thorpe PE (1997) Science 275:547

    Article  CAS  Google Scholar 

  348. Jain RK (2001) Nat Med 7:987

    Article  CAS  Google Scholar 

  349. Jain RK, Carmeliet PF (2001) Sci Am 285:38

    Article  CAS  Google Scholar 

  350. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK (2004) Cancer Res 64:3731

    Article  CAS  Google Scholar 

  351. Lambin P, Landuyt W (2003) Verh K Acad Geneeskd Belg 65:29

    CAS  Google Scholar 

  352. Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y (2000) Cancer Res 60:5565

    CAS  Google Scholar 

  353. Huang S, Armstrong EA, Benavente S, Chinnaiyan P, Harari PM (2004) Cancer Res 64:5355

    Article  CAS  Google Scholar 

  354. Matar P, Rojo F, Cassia R, Moreno-Bueno G, Di Cosimo S, Tabernero J, Guzman M, Rodriguez S, Arribas J, Palacios J, Baselga J (2004) Clin Cancer Res 10:6487

    Article  CAS  Google Scholar 

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  1. Departments of Tumor Biology and Antibody Technology, ImClone Systems Incorporated, 180 Varick Street, 10014, New York, NY, USA

    Keren Paz & Zhenping Zhu

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  1. Keren Paz
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Paz, K., Zhu, Z. (2007). Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2 for Cancer Therapy. In: Bradbury, R.H. (eds) Cancer. Topics in Medicinal Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2006_009

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