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Cancer pp 293-331 | Cite as

HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit

Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 1)

Abstract

This review presents a wide-ranging selection of key literature examples in the histone deacetylase(HDAC) field. The review starts off with the biological background of HDACs and their link to cancer andcancer treatment. The body of the work consists of a categorized and chronological medicinal chemistryoverview. This part describes key medicinal chemistry contributions ranging from the very early HDAC inhibitorsto compounds currently in the clinic. The result of all these medicinal chemistry and biology efforts havebeen captured in the last section that gives an overview of the current status of HDAC inhibitors in theclinic.

Histone deacetylase HDAC inhibitor Hydroxamic acid Clinical development Isoform selective 

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References

  1. 1.
    Suzuki H, Gabrielson E, Chen W, Anbazhagan R, van Engeland M, Weijenberg MP, Herman JG, Baylin SB (2002) Nat Genet 31:141 CrossRefGoogle Scholar
  2. 2.
    Van Lint L, Emiliani S, Verdin E (1996) Gen Express 5:245 Google Scholar
  3. 3.
    Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Hideshima T, Akiyama M, Chauhan D, Munshi N, Gu X, Bailey C, Joseph M, Libermann TA, Richon VM, Marks PA, Anderson KC (2004) Proc Natl Acad Sci 101:540 CrossRefGoogle Scholar
  4. 4.
    Glaser KB, Staver MJ, Waring JF, Stender J, Ulrich RG, Davidsen SK (2003) Mol Cancer Ther 2:151 CrossRefGoogle Scholar
  5. 5.
    McLaughlin F, La Thangue NB (2004) Biochem Pharmacol 68:1139 CrossRefGoogle Scholar
  6. 6.
    Johnstone RW (2002) Nat Rev 1:287 CrossRefGoogle Scholar
  7. 7.
    Dokmanovic M, Marks PA (2005) J Cell Biochem 96:293 CrossRefGoogle Scholar
  8. 8.
    Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN (2004) Prostate 59:177 CrossRefGoogle Scholar
  9. 9.
    Zhu P, Martin E, Mengwasser J, Schlag P, Janssen K-P, Gottlicher M (2004) Cancer Cell 5:455 CrossRefGoogle Scholar
  10. 10.
    Marks PA, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK (2001) Nat Rev 1:194 CrossRefGoogle Scholar
  11. 11.
    Drummond DC, Noble CO, Kirpotin DB, Guo Z, Scott GK, Benz CC (2005) Annu Rev Pharmacol Toxicol 45:495 CrossRefGoogle Scholar
  12. 12.
    Kim MS, Kwon HJ, Lee YM, Baek JH, Jang J-E, Lee S-W, Moon E-J, Kim H-S, Lee S-K, Chung HY, Kim CW, Kim K-W (2001) Nat Med 7:437 CrossRefGoogle Scholar
  13. 13.
    de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB (2003) Biochem J 370:737 CrossRefGoogle Scholar
  14. 14.
    Glaser KB, Li J, Staver MJ, Wei RQ, Albert DH, Davidsen SK (2003) Biochem Biophys Res Commun 310:529 CrossRefGoogle Scholar
  15. 15.
    Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C (2002) EMBO J 21:2672 CrossRefGoogle Scholar
  16. 16.
    Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S, Esteller M (2006) Nat Genet 38:566 CrossRefGoogle Scholar
  17. 17.
    Archer SY, Meng S, Shei A, Hodin RA (1998) Proc Natl Acad Sci 95:6791 CrossRefGoogle Scholar
  18. 18.
    Kim YB, Ki SW, Yoshida M, Horinouchi S (2000) J Antibiot 53:1191 CrossRefGoogle Scholar
  19. 19.
    Juan L-J, Shia W-J, Chen M-H, Yang W-M, Seto E, Lin Y-S, Wu C-W (2000) J Biol Chem 275:20436 CrossRefGoogle Scholar
  20. 20.
    Minucci S, Pelicci PG (2006) Nat Rev Cancer 6:38 CrossRefGoogle Scholar
  21. 21.
    Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (2002) Mol Cell 9:45 CrossRefGoogle Scholar
  22. 22.
    Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ (2003) J Cell Biol 160:1017 CrossRefGoogle Scholar
  23. 23.
    Huang Y, Tan M, Gosink M, Wang KK, Sun Y (2002) Cancer Res 62:2913 Google Scholar
  24. 24.
    Attar RM, Spires T, Jackson D, Feder J, You D, Vivat-Hannah V, Gottardis MM, Lorenzi MV (2003) American Association for Cancer Research 94th Annual Meeting, April 5th–9th, Toronto, Canada, abstract 72 Google Scholar
  25. 25.
    Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K (2005) J Biol Chem 280:26729 CrossRefGoogle Scholar
  26. 26.
    Murphy PJM, Morishima Y, Kovacs JJ, Pao T-P, Pratt WB (2005) J Biol Chem 280:33792 CrossRefGoogle Scholar
  27. 27.
    Zhang Y, Li N, Caron C, Matthias G, Hess D, Khochbin S, Matthias P (2003) EMBO J 22:1168 CrossRefGoogle Scholar
  28. 28.
    Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL (2003) Proc Natl Acad Sci USA 100:4389 CrossRefGoogle Scholar
  29. 29.
    Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP (2003) Cell 115:727 CrossRefGoogle Scholar
  30. 30.
    Riggs MG, Whittaker RG, Neumann JR, Ingram VM (1977) Nature 268:462 CrossRefGoogle Scholar
  31. 31.
    Cousens LS, Gallwitz D, Alberts BM (1979) J Biol Chem 254:1716 Google Scholar
  32. 32.
    Boffa LC, Vidali G, Mann RS, Allfrey VG (1978) J Biol Chem 253:3364 Google Scholar
  33. 33.
    Sealy L, Chalkley R (1978) Cell 14:115 CrossRefGoogle Scholar
  34. 34.
    Candido EPM, Reeves R, Davie JR (1978) Cell 14:105 CrossRefGoogle Scholar
  35. 35.
    Tsuji N, Kobayashi M, Nagashima K, Wakisaka Y, Koizumi K (1976) J Antibiot 29:1 CrossRefGoogle Scholar
  36. 36.
    Yoshida M, Kijima M, Akita M, Beppu T (1990) J Biol Chem 265:17174 Google Scholar
  37. 37.
    Yoshida M, Nomura S, Beppu T (1987) Cancer Res 47:3688 Google Scholar
  38. 38.
    Kijima M, Yoshida M, Sugita K, Horinouchi S, Beppu T (1993) J Biol Chem 268:22429 Google Scholar
  39. 39.
    Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, Okuhara M (1994) J Antibiot 47:301 CrossRefGoogle Scholar
  40. 40.
    Shigematsu N, Ueda H, Takase S, Tanaka H (1994) J Antibiot 47:311 CrossRefGoogle Scholar
  41. 41.
    Ueda H, Manda T, Matsumoto S, Mukumoto S, Nishigaki F, Kawamura I, Shimomura K (1994) J Antibiot 47:315 CrossRefGoogle Scholar
  42. 42.
    Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S (1998) Exp Cell Res 241:126 CrossRefGoogle Scholar
  43. 43.
    Furumai R, Matsuyama A, Kobashi N, Lee K-H, Nishiyama M, Nakajima H, Tanaka A, Komatsu Y, Nishino N, Yoshida M, Horinouchi S (2002) Cancer Res 62:4916 Google Scholar
  44. 44.
    Taunton J, Hassig CA, Schreiber SL (1996) Science 272:408 CrossRefGoogle Scholar
  45. 45.
    Richon VM, Webb Y, Merger R, Sheppard T, Jursic B, Ngo L, Civoli F, Breslow R, Rifkind RA, Marks PA (1996) Proc Natl Acad Sci USA 93:5705 CrossRefGoogle Scholar
  46. 46.
    Richon VM, Emiliani S, Verdin E, Webb Y, Breslow R, Rifkind RA, Marks PA (1998) Proc Natl Acad Sci USA 95:3003 CrossRefGoogle Scholar
  47. 47.
    Hassig CA, Tong JK, Fleischer TC, Owa T, Grable PG, Ayer DE, Schreiber SL (1998) Proc Natl Acad Sci USA 95:3519 CrossRefGoogle Scholar
  48. 48.
    Finnin MS, Donigian JR, Cohen A, Richon VM, Rifkind RA, Marks PA, Breslow R, Pavletich NP (1999) Nature 401:188 CrossRefGoogle Scholar
  49. 49.
    Closse A, Huguenin R (1974) Helv Chim Acta 57:533 CrossRefGoogle Scholar
  50. 50.
    De Schepper S, Bruwiere H, Verhulst T, Steller U, Andries L, Wouters W, Janicot M, Arts J, Van Heusden J (2003) J Pharm Exp Ther 304:881 CrossRefGoogle Scholar
  51. 51.
    Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S (2001) Proc Natl Acad Sci USA 98:87 CrossRefGoogle Scholar
  52. 52.
    Nishino N, Jose B, Shinta R, Kato T, Komatsu Y, Yoshida M (2004) Bioorg Med Chem 12:5777 CrossRefGoogle Scholar
  53. 53.
    Nishino N, Yoshikawa D, Watanabe LA, Kato T, Jose B, Komatsu Y, Sumida Y, Yoshida M (2004) Bioorg Med Chem Lett 14:2427 CrossRefGoogle Scholar
  54. 54.
    Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley KM, Allocco JJ, Cannova C, Meinke PT, Colletti SL, Bednarek MA, Singh SB, Goetz MA, Dombrowski AW, Polishook JD, Schimatz DM (1996) Proc Natl Acad Sci USA 93:13143 CrossRefGoogle Scholar
  55. 55.
    Nishino N, Jose B, Okamura S, Ebisusaki S, Kato T, Sumida Y, Yoshida M (2003) Org Lett 5:5079 CrossRefGoogle Scholar
  56. 56.
    Mulder GJ, Meerman JH (1983) Environ Health Perspect 49:27 CrossRefGoogle Scholar
  57. 57.
    Suzuki T, Kouketsu A, Matsuura A, Kohara A, Nimomiya S-I, Kohda K, Miyata N (2004) Bioorg Med Chem Lett 14:3313 CrossRefGoogle Scholar
  58. 58.
    Frey RR, Wada CK, Garland RB, Curtin ML, Michaelides MR, Li J, Pease LJ, Glaser KB, Marcotte PA, Bouska JJ, Murphy SS, Davidsen SK (2002) Bioorg Med Chem Lett 12:3443 CrossRefGoogle Scholar
  59. 59.
    Walter MW, Felici A, Galleni M, Soto RP, Adlington RM, Baldwin JE, Frère J-M, Golobov M, Schofield CJ (1996) Bioorg Med Chem Lett 6:2455 CrossRefGoogle Scholar
  60. 60.
    Yoshida M, Kijima M, Akita M, Beppu T (1990) J Biol Chem 265:17174 Google Scholar
  61. 61.
    Vasudevan A, Ji Z, Frey RR, Wada CK, Steinman D, Heyman HR, Guo Y, Curtin ML, Guo J, Li J, Pease L, Glaser KB, Marcotte PA, Bouska JJ, Davidsen SK, Michaelides MR (2003) Bioorg Med Chem Lett 13:3909 CrossRefGoogle Scholar
  62. 62.
    Saito A, Yamashita T, Mariko Y, Nosaka Y, Tsuchiya K, Ando T, Suzuki T, Tsuruo T, Nakanishi O (1999) Proc Natl Acad Sci USA 96:4592 CrossRefGoogle Scholar
  63. 63.
    Suzuki T, Ando T, Tsuchiya K, Fukazawa N, Saito A, Mariko Y, Yamashita T, Nakanishi O (1999) J Med Chem 42:3001 CrossRefGoogle Scholar
  64. 64.
    el-Beltagi HM, Martens AC, Lelieveld P, Haroun EA, Hagenbeek A (1993) Cancer Res 53:3008 Google Scholar
  65. 65.
    Kraker AJ, Mizzen CA, Hartl BG, Miin J, Allis CD, Merriman RL (2003) Mol Cancer Ther 2:401 Google Scholar
  66. 66.
    Loprevite M, Tiseo M, Grossi F, Scolaro T, Semino C, Pandolfi A, Favoni R, Ardizzoni A (2005) Oncol Res 15:39 Google Scholar
  67. 67.
    Lelieveld P, Middeldorp RJF, van Putten LM (1985) Cancer Chemother Pharmacol 15:88 CrossRefGoogle Scholar
  68. 68.
    Acharya MR, Sparreboom A, Venitz J, Figg WD (2005) Mol Pharmacol 68:917 CrossRefGoogle Scholar
  69. 69.
    Kouraklis G, Theocharis S (2006) Oncol Rep 15:489 Google Scholar
  70. 70.
    Curtin M, Glaser K (2003) Curr Med Chem 10:2373 CrossRefGoogle Scholar
  71. 71.
    Hu E, Dul E, Sung C-M, Chen Z, Kirkpatrick R, Zhang G-F, Johanson K, Liu R, Lago A, Hofmann G, Macarron R, de los Frailes M, Perez P, Krawiec J, Winkler J, Jaye M (2003) J Pharmacol Exp Ther 307:720 CrossRefGoogle Scholar
  72. 72.
    Glaser KB, Li J, Pease LJ, Staver MJ, Marcotte PA, Guo J, Frey RR, Garland RB, Heyman HR, Wada CK, Vasudevan A, Michaelides MR, Davidsen SK, Curtin ML (2004) Biochem Biophys Res Comm 325:683 CrossRefGoogle Scholar
  73. 73.
    Dokmanovic M, Marks PA (2005) J Cell Biochem 96:293 CrossRefGoogle Scholar
  74. 74.
    Glaser KB, Staver MJ, Waring JF, Stender J, Ulrich RG, Davidsen SK (2003) Mol Cancer Ther 2:151 CrossRefGoogle Scholar
  75. 75.
    Delorme D, Ruel R, Lavoie R, Thibault C, Abou-Khalil E WO 01/38322 A1 (2001) Chem Abstr 135:5455 Google Scholar
  76. 76.
    Lavoie R, Bouchain G, Frechette S, Woo SH, Khalil EA, Leit S, Fournel M, Yan PT, Trachy-Bourget M-C, Beaulieu C, Li Z, Besterman J, Delorme D (2001) Bioorg Med Chem Lett 11:2847 CrossRefGoogle Scholar
  77. 77.
    Bouchain G, Leit S, Frechette S, Abou Khalil E, Lavoie R, Moradei O, Hyung Woo S, Fournel M, Yan PT, Kalita A, Trachy-Bourget M-C, Beaulieu C, Li Z, Robert M-F, Robert MacLeod A, Besterman JM, Delorme D (2003) J Med Chem 46:820 CrossRefGoogle Scholar
  78. 78.
    Finn PW, Bandara M, Butcher C, Finn A, Hollinshead R, Khan N, Law N, Murthy S, Romero R, Watkins C, Andrianov V, Bokaldere RM, Dikovska K, Gailite V, Loza E, Piskunova I, Starchenkov I, Vorona M, Kalvinch I (2005) Helv Chim Acta 88:1630 CrossRefGoogle Scholar
  79. 79.
    Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, La Thangue NB, Brown R (2003) Mol Cancer Ther 2:721 Google Scholar
  80. 80.
    Plumb JA, Steele N, Evans TRJ, Finn PW, Jensen PB, Kristeleit R, de Bono JS, Brown R (2004) EORTC-NCI-AACR Int Conf on Molecular Targets and Cancer Therapeutics, September 28–October 1, Geneva Google Scholar
  81. 81.
    Uesato S, Kitagawa M, Nagaoka Y, Maeda T, Kuwajima H, Yamori T (2002) Bioorg Med Chem Lett 12:1347 CrossRefGoogle Scholar
  82. 82.
    Mori H, Sakamoto K, Tsurumi Y, Takase S, Hino M (2000) WO 00/21979 Google Scholar
  83. 83.
    Arts J, de Schepper S, Van Emelen K (2003) Curr Med Chem 10:2343 CrossRefGoogle Scholar
  84. 84.
    Angibaud P, Arts J, Van Emelen K, Poncelet V, Pilatte I, Roux B, Van Brandt S, Verdonck M, De Winter H, Ten Holte P, Marien A, Floren W, Janssens B, Van Dun J, Aerts A, Van Gompel J, Gaurrand S, Queguiner L, Argoullon J-M, Van Hijfte L, Freyne E, Janicot M (2005) Eur J Med Chem 40:597 CrossRefGoogle Scholar
  85. 85.
    Dai Y, Guo Y, Guo J, Pease LJ, Li J, Marcotte PA, Glaser KB, Tapang P, Albert DH, Richardson PL, Davidsen SK, Michaelides MR (2003) Bioorg Med Chem Lett 13:1897 CrossRefGoogle Scholar
  86. 86.
    Remiszewski SW, Sambucetti LC, Bair KW, Bontempo J, Cesarz D, Chandramouli N, Chen R, Cheung M, Cornell-Kennon S, Dean K, Diamantidis G, France D, Green MA, Lulu Howell K, Kashi R, Kwon P, Lassota P, Martin MS, Mou Y, Perez LB, Sharma S, Smith T, Sorensen E, Taplin F, Trogani N, Versace R, Walker H, Weltchek-Engler S, Wood A, Wu A, Atadja P (2003) J Med Chem 46:4609 CrossRefGoogle Scholar
  87. 87.
    Dai Y, Guo Y, Curting ML, Li J, Pease LJ, Guo J, Marcotte PA, Glaser Kb, Davidsen SK, Michaelides MR (2003) Bioorg Med Chem Lett 13:3817 CrossRefGoogle Scholar
  88. 88.
    Verdin E, Dequiedt F, Kasler H (2003) Trends Genet 19:286 CrossRefGoogle Scholar
  89. 89.
    Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN (2004) Cell 119:555 CrossRefGoogle Scholar
  90. 90.
    Lu J, McKinsey TA, Zhang CL, Olson EN (2000) Mol Cell 6:233 CrossRefGoogle Scholar
  91. 91.
    Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN (2002) Cell 110:479 CrossRefGoogle Scholar
  92. 92.
    Antos CL, McKinsey TA, Dreitz M, Hollingsworth LM, Zhang CL, Schreiber K, Rindt H, Gorczynski RJ, Olson EN (2003) J Biol Chem 278:28930 CrossRefGoogle Scholar
  93. 93.
    Sternson SM, Wong JC, Grozinger CM, Schreiber SL (2001) Org Lett 3:4239 CrossRefGoogle Scholar
  94. 94.
    Haggarty SJ, Koeller KM, Wong JC, Butcher RA, Schreiber SL (2003) Chem Biol 10:383 CrossRefGoogle Scholar
  95. 95.
    Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF, Yao TP (2002) Nature 417:455 CrossRefGoogle Scholar
  96. 96.
    Mai A, Massa S, Cerbara I, Valente S, Ragno R, Bottoni P, Scatena R, Loidl P, Brosch G (2004) J Med Chem 47:1098 CrossRefGoogle Scholar
  97. 97.
    Mai A, Massa S, Ragno R, Cerbara I, Jesacher F, Loidl P, Brosch G (2003) J Med Chem 46:512 CrossRefGoogle Scholar
  98. 98.
    Mai A, Massa S, Valente S, Simeoni S, Ragno R, Bottoni P, Scatena R, Brosch G (2006) ChemMedChem 1:225 CrossRefGoogle Scholar
  99. 99.
    Mai A, Massa S, Pezzi R, Simeoni S, Rotili D, Nebbioso A, Scognamiglio A, Altucci L, Loidl P, Brosch G (2005) J Med Chem 48:3344 CrossRefGoogle Scholar
  100. 100.
    Wang D-F, Helquist P, Wiech NL, Wiest O (2005) J Med Chem 48:6936 CrossRefGoogle Scholar
  101. 101.
    Carducci M, Siu LL, Sullivan R, Maclean M, Kalita A, Chen EX, Pili R, Martell RE, Besterman J, Reid GK (2006) J Clin Oncol ASCO Annual Meeting Proc Part I. Vol 24, No. 18S (June 20 Supplement):3007 Google Scholar
  102. 102.
    Kelly WK, Richon VM, O'Connor O, Curley T, MacGregor-Curtelli B, Tong W, Klang M, Schwartz L, Richardson S, Rosa E, Drobnjak M, Cordon-Dordo C, Chiao HJ, Rifkind R, Marks PA, Scher H (2003) Clin Cancer Res 9:3578 Google Scholar
  103. 103.
    Kelly WK, O'Connor O, Krug LM, Chiao JH, Heaney M, Curley T, MacGregore-Cortelli B, Tong W, Secrist JP, Schwartz L, Richardson S, Chu E, Olgac S, Marks PA, Scher H, Richon VM (2005) J Clin Oncol 23:3923 CrossRefGoogle Scholar
  104. 104.
    O'Connor OA, Heaney ML, Schwartz L, Richardson S, Willim R, MacGregor-Cortelli B, Curly T, Moskowitz C, Portlock C, Horwitz S, Zelenetz AD, Frankel S, Richon V, Marks P, Kelly WK (2006) J Clin Oncol 24:166 CrossRefGoogle Scholar
  105. 105.
    Heaney M, O'Connor O, Richon V, et al. (2003) Proc Am Soc Clin Oncol 577:2321 Google Scholar
  106. 106.
    Rowinsky EK, Pacey S, Patnaik A, et al. (2004) Proc Am Soc Clin Oncol 22:200s Google Scholar
  107. 107.
    Ottmann OG, Deangelo DJ, Stone RM, et al. (2004) Proc Am Soc Clin Oncol 22:201s Google Scholar
  108. 108.
    Beck J, Fischer T, Rowinsky E, et al. (2004) Proc Am Soc Clin Oncol 22:201s Google Scholar
  109. 109.
    Beck J, Fischer T, George D, Huber C, Calvo E, Atadja P, Peng B, Kwong C, Sharma S, Patnaik A (2005) J Clin Oncol (Meeting Abstracts) 23:3148 Google Scholar
  110. 110.
    Kristeleit RS, Tandy D, Atadja P, et al. (2004) Proc Am Soc Clin Oncol 22:200s Google Scholar
  111. 111.
    Rowinsky EK, de Bono JS, Deangelo DJ, van Oosterom A, Morganroth J, Laird GH, Dugan M, Scott JW, Ottmann OG (2005) J Clin Oncol (Meeting Abstracts) 23:3131 Google Scholar
  112. 112.
    Fischer T, Patnaik A, Bhalla K, Beck J, Morganroth J, Laird GH, Sharma S, Scott JW, Dugan M, Giles F (2005) J Clin Oncol (Meeting Abstracts) 23:3106 Google Scholar
  113. 113.
    Fischer T, Patnaik A, Bhalla K, Beck J, Morganroth J, Laird GH, Sharma S, Scott JW, Dugan M, Giles F (2005) J Clin Oncol, 2005 ASCO Annual Meeting Proc. Vol 23, No 16S (June 1 Supplement):3106 Google Scholar
  114. 114.
    Garcia-Manero G, Yang H, Sanchez-Gonzalez B, Verstovsek S, Ferrajoli A, Keating M, Andreeff M, O'Brien S, Cortes J, Wierda W, Faderl S, Koller C, Davis J, Morris G, Issa J-P, Frankel SR, Richon V, Fine B, Kantarjian H (2005) Blood (ASH Annual Meeting Abstracts)106:2801 Google Scholar
  115. 115.
    Blumenschein G, Lu C, Kies M, Glisson B, Papadimitrakopoulou V, Zinner R, Kim E, Gillenwater A, Chiao J, Hong W (2004) J Clin Oncol (Meeting Abstracts) 22:5578 Google Scholar
  116. 116.
    Duvic M, Tallpur R, Zhang C, Goy A, Richon V, Frankel SR (2005) J Clin Oncol (Meeting Abstracts) 23:577s (suppl, abstr 6571) Google Scholar
  117. 117.
    de Bono JS, Steele N, Vidal L et al. (2005) AACR-EORTC-NCI Int Conf on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Philadelphia, November 14–18, 220 (Abstract C88) Google Scholar
  118. 118.
    Gilbert J, Baker SD, Bowling MK, Grochow L, Figg WD, Zabelina Y, Donehower RC, Carducci MA (2001) Clin Cancer Res 7:2292 Google Scholar
  119. 119.
    Carducci MA, Gilbert J, Bowling MK, Noe D, Eisenberger MA, Sinibaldi V, Zabelina Y, Chen T, Grochow LB, Donehower RC (2001) Clin Cancer Res 7:3047 Google Scholar
  120. 120.
    Gore SD, Weng LJ, Figg WD, Zhai S, Donehower RC, Dover G, Grever MR, Griffin C, Grochow LB, Hawkins A, Burks K, Zabelena Y, Miller CB (2002) Clin Cancer Res 8:963 Google Scholar
  121. 121.
    Patnaik A, Rowinsky EK, Villalona MA, Hammond LA, Britten CD, Siu LL, Goetz A, Felton SA, Burton S, Valone FH, Eckhardt SG (2002) Clin Cancer Res 8:2142 Google Scholar
  122. 122.
    Reid T, Valone F, Lipera W, Irwin D, Paroly W, Natale R, Sreedharan S, Keer H, Lum B, Scappaticci F, Bhatnagar A (2004) Lung Cancer 45:381 CrossRefGoogle Scholar
  123. 123.
    Siu L, Carducci M, Pearce L, et al. (2005) AACR-EORTC-NCI Int Conf on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Philadelphia, November 14–18, 217 (Abstract C77) Google Scholar
  124. 124.
    Sandor V, Bakke S, Robey RW, Kang MH, Blagosklonny MV, Bender J, Brooks R, Piekarz RL, Tucker E, Figg WD, Chan KK, Goldspiel B, Fojo AT, Balcerzak SP, Bates SE (2002) Clin Cancer Res 8:718 Google Scholar
  125. 125.
    Marshall JL, Rizvi R, Kauh J, Dahut W, Figuera M, Kang MH, Figg WD, Wainer I, Chaissang C, Li MZ, Hawkins MJ (2002) J Exp Ther Oncol 2:325 CrossRefGoogle Scholar
  126. 126.
    Piekarz RL, Frye AR, Wright JJ, Steinberg SM, Liewehr DJ, Rosing DR, Sachdev V, Fojo T, Bates SE (2006) Clin Cancer Res 12:3762 CrossRefGoogle Scholar
  127. 127.
    Piekarz RL, Frye R, Turner M, Wright J, Leonard J, Allen S, Smith S, Kischbaum M, Zain J, Bates SE for all collaborators (2005) J Clin Oncol (Meeting Abstracts) 23:3061 CrossRefGoogle Scholar
  128. 128.
    Stadler WM, Swerdloff JN, Margolin K, McCulloch B, Thompson J (2005) J Clin Oncol (Meeting Abstracts) 23:420s (suppl, abstr 4669) Google Scholar
  129. 129.
    Molife R, Patterson S, Riggs C, et al. (2006) Proc Am Soc Clin Oncol Prostate Cancer Symposium:217a Google Scholar
  130. 130.
    Whitehead R, McCoy S, Wollner I et al. (2006) Proc Am Soc Clin Oncol Gastrointestinal Cancers Symposium:255a Google Scholar
  131. 131.
    Odenike OM, Alkan S, Sher D, Godwin JE, Huo D, Myers M, Brandt SJ, Zhang Y, Vesole DH, Larson RA, Stock W (2004) Blood (ASH Annual Meeting Abstracts) 104:264 Google Scholar
  132. 132.
    Niesvizky R, Ely S, DiLiberto M, Cho HJ, Gelbshtein UY, Jayabalan DS, Aggarwal S, Gabrilove JL, Pearse RN, Pekle K, Zafar F, Goldberg Z, Leonard JP, Wright JJ, Chen-Kiang S, Coleman M (2005) Blood (ASH Annual Meeting Abstracts) 106:2574 Google Scholar
  133. 133.
    Ryan QC, Headlee D, Acharya M, Sparreboom A, Trepel JB, Ye J, Figg WD, Hwang K, Chung EJ, Murgo A, Melillo G, Elsayed Y, Monga M, Kalnitskiy M, Zwiebel J, Sausville EA (2005) J Clin Oncol 23:3912 CrossRefGoogle Scholar
  134. 134.
    Donovan EA, Ryan Q, Acharya M, Cheng E, Trepel J, Maynard K, Sausville E, Murgo A, Melillo G, Conley B (2005) J Clin Oncol (Meeting Abstracts) 23:3094 CrossRefGoogle Scholar
  135. 135.
    Gore L, Holden SD, Basche M, et al. (2004) Proc Am Soc Clin Oncol 22:201s Google Scholar
  136. 136.
    Prakash S, Foster BJ, Meyer M, Wozniak A, Heilbrun LK, Flaherty L, Zalupski M, Radulovic L, Valdivieso M, LoRusso PM (2001) Invest New Drugs 19:1 CrossRefGoogle Scholar
  137. 137.
    Byrd JC, Maarcuccu G, Parthun MR, Xiao JJ, Klisovic RB, Moran M, Lin TS, Liu S, Sklenar AR, Davis ME, Lucas DM, Fischer B, Shank R, Tejaswi SL, Binkley P, Wright J, Chan KK, Grever MR (2005) Blood 105:959 CrossRefGoogle Scholar
  138. 138.
    Lindemann RK, Gabrielli B, Johnstone R (2004) Cell Cycle 3:779 CrossRefGoogle Scholar
  139. 139.
    Bug G, Ritter M, Wassmann B, Schoch C, Heinzel T, Schwarz K, Romanski A, Kramer OH, Kampfmann M, Hoelzer D, Neubauer A, Ruthardt M, Ottmann OG (2005) Cancer 104:2717 CrossRefGoogle Scholar
  140. 140.
    Pauer LR, Olivares J, Cunningham C, Williams A, Grove W, Kraker A, Olson S, Nemunaitis J (2004) Cancer Invest 22:886 CrossRefGoogle Scholar
  141. 141.
    Undevia SD, Kindler HL, Janisch L, Olson SC, Schilsky RL, Vogelzang NJ, Kimmel KA, Macek TA, Ratain MJ (2004) Ann Oncol 15:1705 CrossRefGoogle Scholar
  142. 142.
    Nemunaitis JJ, Orr D, Eager R, Cunningham CC, Williams A, Mennel R, Grove W, Olson S (2003) Cancer J 9:58 CrossRefGoogle Scholar
  143. 143.
    von Pawel J, Shepherd F, Gatzmeier U, et al. (2002) Proc Am Soc Clin Oncol 21:310a Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.Dept. of Medicinal ChemistryJohnson & Johnson Pharmaceutical Research & Development, Division of Janssen PharmaceuticaNVBeerseBelgium
  2. 2.Dept. of OncologyJohnson & Johnson Pharmaceutical Research & Development, Division of Janssen PharmaceuticaNVBeerseBelgium
  3. 3.Drug Development UnitRoyal Marsden HospitalSuttonUK

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