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Cancer pp 293–331Cite as

HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit

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Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 1))

Abstract

This review presents a wide-ranging selection of key literature examples in the histone deacetylase(HDAC) field. The review starts off with the biological background of HDACs and their link to cancer andcancer treatment. The body of the work consists of a categorized and chronological medicinal chemistryoverview. This part describes key medicinal chemistry contributions ranging from the very early HDAC inhibitorsto compounds currently in the clinic. The result of all these medicinal chemistry and biology efforts havebeen captured in the last section that gives an overview of the current status of HDAC inhibitors in theclinic.

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Authors and Affiliations

  1. Dept. of Medicinal Chemistry, Johnson & Johnson Pharmaceutical Research & Development, Division of Janssen PharmaceuticaNV, 2340, Beerse, Belgium

    P. ten Holte & K. Van Emelen

  2. Dept. of Oncology, Johnson & Johnson Pharmaceutical Research & Development, Division of Janssen PharmaceuticaNV, 2340, Beerse, Belgium

    M. Janicot & J. Arts

  3. Drug Development Unit, Royal Marsden Hospital, Sutton, UK

    P. C. Fong & J. S. de Bono

Authors
  1. P. ten Holte
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  2. K. Van Emelen
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  3. M. Janicot
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  4. P. C. Fong
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  5. J. S. de Bono
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  6. J. Arts
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Correspondence to P. ten Holte .

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Robert H. Bradbury

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ten Holte, P., Van Emelen, K., Janicot, M., Fong, P.C., de Bono, J.S., Arts, J. (2007). HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit. In: Bradbury, R.H. (eds) Cancer. Topics in Medicinal Chemistry, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2006_007

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