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Cancer pp 207-291 | Cite as

Progress in the Development of Agents to Control the Cell Cycle

Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 1)

Abstract

Inhibitors of the kinases controlling the cell cycle have emerged as an important therapeuticmodality for the treatment of cancer. Drug discovery efforts have focused on inhibitors of the cyclin-dependentkinases, the Aurora kinases, and Polo-like kinases. Agents for each kinase are now advancing in humanclinical trials. In this review we will summarize the work in this area with special emphasis onthe structural biology and structure–activity relationships developed for the many chemotypesexplored.

Aurora CDK Cell cycle Kinase PLK 

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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.Oncology Research TeamSpring House Research and Early Development Site, Johnson & Johnson PharmaceuticalResearch and DevelopmentSpringhouseUSA

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