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Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes pp 21–73Cite as

Protein Import into Hydrogenosomes and Mitosomes

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Part of the book series: Microbiology Monographs ((MICROMONO,volume 9))

Abstract

In the past decade, studies on protein targeting to hydrogenosomes and mitosomes have revealed several characteristics in common with mitochondrial protein targeting. Proteins from one system can readily be imported into another, strongly suggesting that targeting signals on hydrogenosomal, mitosomal and mitochondrial preproteins are conserved. By extension, these observations, together with the proposed common origin of hydrogenosomes, mitosomes and mitochondria, led to the proposition that components of the respective protein import machineries for these organelles are conserved. With the advent of complete genome sequence databases for diverse eukaryotes, we are now in a better position to examine this proposition. In this review, we report and integrate the latest experimental and bioinformatics data on the state of protein import in hydrogenosomes, mitosomes and mitochondria.

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  1. School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, NG7 2UH, Nottingham, UK

    Sabrina D. Dyall

  2. Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, 3010, Parkville, Australia

    Pavel Dolezal

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Dyall, S.D., Dolezal, P. (2007). Protein Import into Hydrogenosomes and Mitosomes. In: Tachezy, J. (eds) Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes. Microbiology Monographs, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_2007_105

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