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Type III Secretion Systems: Bacterial Injection Devices for Microbe–Host Interactions

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Complex Intracellular Structures in Prokaryotes

Part of the book series: Microbiology Monographs ((MICROMONO,volume 2))

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Abstract

Many pathogenic and symbiotic bacteria interact with their eukaryotic host using a complex proteinsecretion apparatus termed the type III secretion system. Type III secretion systems are multiprotein machineriesthat form a complex syringe-like organelle spanning the entire Gram-negative bacterial envelope. Thebacteria use these machineries to translocate effector proteins into the host cells that either enable themto evade the host's immune system or help establish a close relationship that is necessary to engagein a mutualistic symbiosis. This work discusses the occurrence, structure, and regulation of thesenovel and important protein translocation systems.

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Authors and Affiliations

  1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, MD, USA

    Kirill Sergueev, Colleen A. McHugh & Egbert Hoiczyk

Authors
  1. Kirill Sergueev
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  2. Colleen A. McHugh
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  3. Egbert Hoiczyk
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Corresponding author

Correspondence to Egbert Hoiczyk .

Editor information

Jessup M. Shively

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© 2006 Springer-Verlag Berlin Heidelberg

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Sergueev, K., McHugh, C.A., Hoiczyk, E. (2006). Type III Secretion Systems: Bacterial Injection Devices for Microbe–Host Interactions. In: Shively, J.M. (eds) Complex Intracellular Structures in Prokaryotes. Microbiology Monographs, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_033

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