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Carboxysomes and Carboxysome-like Inclusions

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Complex Intracellular Structures in Prokaryotes

Part of the book series: Microbiology Monographs ((MICROMONO,volume 2))

Abstract

Carboxysomes and related polyhedral bacterial inclusions are complex structures that are composedof a limited set of related proteins. The importance of these prokaryotic organelles as metabolicorganizers in autotrophs as well as heterotrophic bacteria is becoming much more apparent. The carboxysome,which is by far the best characterized representative of these inclusions, is found in a variety ofphylogenetically distant autotrophic bacteria and contains the central CO 2fixing enzyme, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO). The particle participates in theessential CO2 concentrating mechanism and is likely protecting RuBisCO from oxygen.By contrast, the functions of polyhedral inclusions in heterotrophic prokaryotes that have been experimentallyobserved or inferred from comparative genomic analyses are less well understood. This review summarizesthe current state of knowledge regarding structure, function and genetics of carboxysomes and related polyhedralmicrocompartments.

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Acknowledgments

SH and GCC acknowledge financial support from the National Science Foundation (MCB 0444568 and DMR 0213883).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, The University of Southern Mississippi, 118 College Dr. #5043, 38406-0001, Hattiesburg, MS, USA

    Sabine Heinhorst, Gordon C. Cannon & Jessup M. Shively

  2. Department of Genetics and Biochemistry, Clemson University, 29634-0318, Clemson, SC, USA

    Jessup M. Shively

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  1. Sabine Heinhorst
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  2. Gordon C. Cannon
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  3. Jessup M. Shively
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Correspondence to Sabine Heinhorst .

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Jessup M. Shively

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Heinhorst, S., Cannon, G.C., Shively, J.M. (2006). Carboxysomes and Carboxysome-like Inclusions. In: Shively, J.M. (eds) Complex Intracellular Structures in Prokaryotes. Microbiology Monographs, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7171_023

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