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Carbohydrate-spiro-heterocycles pp 261–290Cite as

Spiro Iminosugars: Structural Diversity and Synthetic Strategies

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Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 57))

Abstract

From their discovery in the late 1960s, iminosugars have undergone an expansion from an area of science limited to a few researchers to a field that now attracts the interest of members of the whole synthetic organic chemistry community. Indeed, many tasks concern structural modifications of standard iminosugars in order to improve their biological and pharmacological properties. In this way, the introduction of an adjoining spirocycle afforded unprecedented polyhydroxy-azaspiranes, the structures and syntheses of which are presented in this chapter. Special attention is paid to the key steps involved in the generation of the pivotal quaternary spiro atom.

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Authors and Affiliations

  1. Laboratoire d’Innovation Moléculaire et Applications, Univ. de Strasbourg, Univ. de Haute-Alsace, CNRS, LIMA (UMR 7042), Equipe de Synthèse Organique et Molécules Bioactives (SYBIO), ECPM, Strasbourg, France

    Damien Hazelard, Raphaël Hensienne & Philippe Compain

  2. Institut de Chimie Moléculaire de Reims, Univ. Reims Champagne Ardenne, CNRS (UMR 7312), Méthodologie en Synthèse Organique (MSO), Reims Cedex 2, France

    Jean-Bernard Behr

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  1. Damien Hazelard
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  2. Raphaël Hensienne
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  3. Jean-Bernard Behr
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  4. Philippe Compain
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Corresponding author

Correspondence to Philippe Compain .

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Editors and Affiliations

  1. Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary

    László Somsák

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Hazelard, D., Hensienne, R., Behr, JB., Compain, P. (2019). Spiro Iminosugars: Structural Diversity and Synthetic Strategies. In: Somsák, L. (eds) Carbohydrate-spiro-heterocycles. Topics in Heterocyclic Chemistry, vol 57. Springer, Cham. https://doi.org/10.1007/7081_2019_29

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