Abstract
Iminium ion chemistry represents a versatile transformation capable of introducing structurally diverse constraints into peptide backbones. The compatibility of iminium ion chemistry with traditional solid-phase peptide synthesis methods enables the introduction of constraints without requiring solution-phase synthesis. This chapter describes the introduction of constrained molecular scaffolds composed of single, fused, and bridged heterocycles into peptide backbones.
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Acknowledgment
This work was supported by the Department of Chemistry and Biochemistry, University of Notre Dame as well as the projects P207/12/0473 from Czech Science Foundation (GACR) and CZ.1.07/2.3.00/30.0060 and 1.07/2.3.00/30.0004 from the European Social Fund.
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La-Venia, A., Ventosa-Andrés, P., Krchňák, V. (2015). Peptidomimetics via Iminium Ion Chemistry on Solid Phase: Single, Fused, and Bridged Heterocycles. In: Lubell, W. (eds) Peptidomimetics II. Topics in Heterocyclic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/7081_2015_194
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DOI: https://doi.org/10.1007/7081_2015_194
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