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Recent Studies on Gramicidin S Analog Structure and Antimicrobial Activity

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Peptidomimetics II

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 49))

Abstract

Gramicidin S, the most notable example of cationic antimicrobial peptides (CAPs), has remained in the forefront of worldwide research for development of new antibiotics for over seven decades now. Hundreds of papers have been published over the years on this molecule and its numerous analogs, delineating their structures and biological activities with an aim to achieve selective antimicrobial activities with reduced cytotoxicity for potential therapeutic applications. The present review attempts to capture the essence of some of the recent studies with the aims to chronicle the journey traversed by this fascinating molecule so far and to decipher what is needed for future success.

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Authors and Affiliations

  1. CSIR-Central Drug Research Institute, Lucknow, 226031, India

    Sudip Pal & Ravi Sankar Ampapathi

  2. Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560012, India

    Uttam Ghosh & Tushar Kanti Chakraborty

Authors
  1. Sudip Pal
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  2. Uttam Ghosh
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  3. Ravi Sankar Ampapathi
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  4. Tushar Kanti Chakraborty
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Corresponding author

Correspondence to Tushar Kanti Chakraborty .

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Editors and Affiliations

  1. Départemente de Chimie, Université de Montréal Départemente de Chimie, MONTREAL, Québec, Canada

    William Lubell

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Dedicated to Prof. S. Chandrasekaran on the occasion of his 70th birthday.

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Pal, S., Ghosh, U., Ampapathi, R.S., Chakraborty, T.K. (2015). Recent Studies on Gramicidin S Analog Structure and Antimicrobial Activity. In: Lubell, W. (eds) Peptidomimetics II. Topics in Heterocyclic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/7081_2015_188

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