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Heterocyclic Extended Peptide Surrogates for β-Strand Stabilization

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Book cover Peptidomimetics II

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 49))

Abstract

Peptidomimetic scaffolds designed to stabilize biologically relevant secondary structures play a key role in ligand-based drug design. Approaches aimed at stabilizing extended peptide conformations hold particular promise for targeting β-strand and β-sheet interactions. An understanding of how specific constraints impact extended backbone conformations is needed to expand their potential utility and to inform the design of novel templates. This chapter describes peptide orthotic and prosthetic approaches toward β-strand stabilization using heterocyclic motifs. Syntheses and conformational analyses are described for selected extended peptide surrogates suitable for incorporation into native sequences.

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Authors and Affiliations

  1. Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., Tampa, FL, 33620, USA

    Juan R. Del Valle

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  1. Juan R. Del Valle
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Correspondence to Juan R. Del Valle .

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Editors and Affiliations

  1. Départemente de Chimie, Université de Montréal Départemente de Chimie, MONTREAL, Québec, Canada

    William Lubell

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Del Valle, J.R. (2015). Heterocyclic Extended Peptide Surrogates for β-Strand Stabilization. In: Lubell, W. (eds) Peptidomimetics II. Topics in Heterocyclic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/7081_2015_163

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