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Metalation of Azoles and Related Five-Membered Ring Heterocycles pp 47–76Cite as

Furans and Benzofurans

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Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 29))

Abstract

This chapter reviews the significant developments in the metalation of furans and benzofurans and applications of the resulting metalated species in the past decade. New and interesting metalated furan and benzofuran derivatives and their novel reactions are featured. Topics encompass lithiation, magnesation and zincation, the use of boronated and other metalated furans and benzofurans in cross-coupling reactions, as well as the use of metalated furans and benzofurans in addition reactions. Examples of regioselective metalation are highlighted, and metalation of related furo heterocycles is also summarized.

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  1. Bristol-Myers Squibb Research and Development, 5 Research Parkway, 5100, Wallingford, CT, 06492, USA

    Kap-Sun Yeung

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Correspondence to Kap-Sun Yeung .

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  1. Dept. Chemistry, Dartmouth College, Burke Laboratory 6128, Hanover, 03755, New Hampshire, USA

    Gordon W. Gribble

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Yeung, KS. (2012). Furans and Benzofurans. In: Gribble, G. (eds) Metalation of Azoles and Related Five-Membered Ring Heterocycles. Topics in Heterocyclic Chemistry, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2012_79

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