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Metalation of Pyrrole

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Book cover Metalation of Azoles and Related Five-Membered Ring Heterocycles

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 29))

Abstract

Metalation reactions of pyrrole and indolizine are reviewed. While the use of pyrrole-based materials in the Suzuki reaction is increasingly popular, several examples of other palladium-catalyzed reactions, such as Negishi, Stille, Sonogashira, and Heck couplings, are included. In addition to these palladium-catalyzed cross-coupling reactions, direct proton abstraction, directed metalation, and halogen–metal exchange are discussed. Applications of these reactions to synthesis of pyrrole natural products and other interesting materials such as BODIPY dyes are summarized.

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Authors and Affiliations

  1. Eastern Mennonite University, 1200 Park Road, Harrisonburg, VA, 22802, USA

    Tara L. S. Kishbaugh

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  1. Tara L. S. Kishbaugh
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Correspondence to Tara L. S. Kishbaugh .

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Editors and Affiliations

  1. Dept. Chemistry, Dartmouth College, Burke Laboratory 6128, Hanover, 03755, New Hampshire, USA

    Gordon W. Gribble

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© 2012 Springer-Verlag Berlin Heidelberg

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Kishbaugh, T.L.S. (2012). Metalation of Pyrrole. In: Gribble, G. (eds) Metalation of Azoles and Related Five-Membered Ring Heterocycles. Topics in Heterocyclic Chemistry, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2012_76

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