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Oxindoles and Spirocyclic Variations: Strategies for C3 Functionalization

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Heterocyclic Scaffolds II:

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 26))

Abstract

This chapter provides an overview of emerging strategies for the selective introduction of functionality at oxindole C3. Specific emphasis has been devoted toward asymmetric methods for the introduction of C3 quaternary centers and spirocyclic ring systems. The chapter has been divided into two sections on general methodology for the stereoselective synthesis of oxindoles and spirooxindoles, respectively. A third section is devoted toward efforts in natural product total synthesis involving oxindole or spirocyclic variants as targets or key intermediates.

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Authors and Affiliations

  1. Division of Natural Science, St. Norbert College, 100 Grant St., De Pere, WI, 54115, USA

    Jonathon S. Russel

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  1. Jonathon S. Russel
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Correspondence to Jonathon S. Russel .

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Editors and Affiliations

  1. Dept. Chemistry, Dartmouth College, Burke Laboratory 6128, Hanover, 03755, New Hampshire, USA

    Gordon W. Gribble

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Russel, J.S. (2010). Oxindoles and Spirocyclic Variations: Strategies for C3 Functionalization. In: Gribble, G. (eds) Heterocyclic Scaffolds II:. Topics in Heterocyclic Chemistry, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2010_50

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