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Bioactive Heterocycles VI pp 161–171Cite as

Changes in Polyamine Levels During Cell Death Induced by Heterocycles

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Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 15))

Abstract

Natural polyamines (putrescine, spermidine, spermine) are aliphatic amines containing 2 or more amino groups, and play an important role in regulating cell growth and differentiation. Depletion of polyamine in cells has been known to inhibit cell proliferation or induce cell death. This review summarizes changes in polyamine levels during cell death induced by the selective properties of various heterocycles.

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Author information

Authors and Affiliations

  1. Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, 350-0283, Saitama, Japan

    Masaki Kobayashi & Hiroshi Sakagami

  2. Faculty of Pharmaceutical Sciences, Matsuyama University, Matsuyama, 790-8578, Ehime, Japan

    Masami Kawase

  3. Meiji Pharmaceutical University, Kiyose, 204-8588, Tokyo, Japan

    Noboru Motohashi

Authors
  1. Masaki Kobayashi
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  2. Hiroshi Sakagami
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  3. Masami Kawase
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  4. Noboru Motohashi
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Corresponding author

Correspondence to Masaki Kobayashi .

Editor information

Noboru Motohashi

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© 2008 Springer-Verlag Berlin Heidelberg

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Kobayashi, M., Sakagami, H., Kawase, M., Motohashi, N. (2008). Changes in Polyamine Levels During Cell Death Induced by Heterocycles. In: Motohashi, N. (eds) Bioactive Heterocycles VI. Topics in Heterocyclic Chemistry, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_102

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