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Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action

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Heterocyclic Antitumor Antibiotics

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 2))

Abstract

Diazonium salts have been previously used to cleave DNA via generation of carbon centered radicals and cations. Efforts have been made in the past decade or so to develop diazo compounds and α-diazoketones for physiologically relevant DNA cleavage. These efforts, coupled with their relevance to the mechanism of action of kinamycin and lomaiviticin antibiotics and other naturally occurring diazo compounds, will be discussed.

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Acknowledgments

The author is grateful for financial support from NSF-CAREER (CHE/MCB-0134972).

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Authors and Affiliations

  1. Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, 461 Hunter, 29634, Clemson, SC, USA

    Dev P. Arya

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  1. Dev P. Arya
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Correspondence to Dev P. Arya .

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Moses Lee

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Arya, D.P. Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action. In: Lee, M. (eds) Heterocyclic Antitumor Antibiotics. Topics in Heterocyclic Chemistry, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_018

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