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Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories

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Book cover Genome Integrity

Part of the book series: Genome Dynamics and Stability ((GENOME,volume 1))

Abstract

This chapter deals with bulk DNA synthesis in the three “Domains” of cellular life – Bacteria, Archaea and Eukarya. Presenting less specific detail, in comparison with other chapters in this volume, it summarizes current views on the vital protein complexes that organize genomic replication: together with numerous accessory proteins, individual replicases build up each strand of newly formed DNA. At least two of these cooperate in a replisome to form both branches of a replication fork, and higher-order replication factories appear to gather the divergently operating forks that have been started at the same origin site. Moreover, the crucial control that limits replication to exactly once per cell cycle is manifested at the level of intricate origin recognition complexes, which in turn initiate the assembly of functional replisomes at appropriate intervals.

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Acknowledgments

The critical comments to this manuscript by Olaf Nielsen and Michi Egel-Mitani are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Genetics, Institute of Molecular Biology and Physiology, University of Copenhagen, Øster Farimagsgade 2A, 1353, Copenhagen, Denmark

    Richard Egel

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  1. Richard Egel
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Correspondence to Richard Egel .

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Dirk-Henner Lankenau

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© 2006 Springer-Verlag Berlin Heidelberg

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Egel, R. (2006). Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories. In: Lankenau, DH. (eds) Genome Integrity. Genome Dynamics and Stability, vol 1. Springer, Berlin, Heidelberg . https://doi.org/10.1007/7050_012

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