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Human Risk Associated with Long-Term Exposure to Pyrethroid Insecticides

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Pyrethroid Insecticides

Part of the book series: The Handbook of Environmental Chemistry ((HEC,volume 92))

Abstract

The aim of this review is to provide a broad summary of the latest state of knowledge about the potential long-term adverse effects of pyrethroids on human health. The oldest and recent epidemiological studies mainly addressed respiratory, neurological, hormonal, and reproductive outcomes in adults after environmental and occupational exposures. Although several of these studies have suggested negative effects, especially on male hormonal and sperm parameters, findings were often equivocal or inconsistent across studies, and no firm and reliable conclusions can be reached yet. Regarding developmental outcomes, there is increasing evidence that fetal exposure to pyrethroids may be associated with poorer children’s neurodevelopment. Prevention measures should be considered to reduce exposure of pregnant women and children to these widely used insecticides.

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References

  1. Saillenfait AM, Ndiaye D, Sabate JP (2015) Pyrethroids: exposure and health effects – an update. Int J Hyg Environ Health 218:281–292

    CAS  Google Scholar 

  2. Koureas M, Tsakalof A, Tsatsakis A, Hadjichristodoulou C (2012) Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes. Toxicol Lett 210:155–168

    CAS  Google Scholar 

  3. Cherry N, Beach J, Senthilselvan A, Burstyn I (2018) Pesticide use and asthma in Alberta grain farmers. Int J Environ Res Public Health 15:E526

    Google Scholar 

  4. Patel O, Syamlal G, Henneberger PK, Alarcon WA, Mazurek JM (2018) Pesticide use, allergic rhinitis, and asthma among US farm operators. J Agromedicine 23:327–335

    Google Scholar 

  5. Hoppin JA, Umbach DM, Long S, London SJ, Henneberger PK, Blair A, Alavanja M, Freeman LE, Sandler DP (2017) Pesticides are associated with allergic and non-allergic wheeze among male farmers. Environ Health Perspect 125:535–543

    CAS  Google Scholar 

  6. Koureas M, Rachiotis G, Tsakalof A, Hadjichristodoulou C (2017) Increased frequency of rheumatoid arthritis and allergic rhinitis among pesticide sprayers and associations with pesticide use. Int J Environ Res Public Health 14:E865

    Google Scholar 

  7. Quansah R, Bend JR, Abdul-Rahaman A, Armah FA, Luginaah I, Essumang DK, Iddi S, Chevrier J, Cobbina SJ, Nketiah-Amponsah E, Adu-Kumi S, Darko G, Afful S (2016) Associations between pesticide use and respiratory symptoms: a cross-sectional study in Southern Ghana. Environ Res 150:245–254

    CAS  Google Scholar 

  8. Lu G, Traore C, Meissner P, Kouyate B, Kynast-Wolf G, Beiersmann C, Coulibaly B, Becher H, Muller O (2015) Safety of insecticide-treated mosquito nets for infants and their mothers: randomized controlled community trial in Burkina Faso. Malar J 14:527

    Google Scholar 

  9. Baumert BO, Carnes MU, Hoppin JA, Jackson CL, Sandler DP, Freeman LB, Henneberger PK, Umbach DM, Shrestha S, Long S, London SJ (2018) Sleep apnea and pesticide exposure in a study of US farmers. Sleep Health 4:20–26

    Google Scholar 

  10. Ye M, Beach J, Martin JW, Senthilselvan A (2016) Urinary concentrations of pyrethroid metabolites and its association with lung function in a Canadian general population. Occup Environ Med 73:119–126

    Google Scholar 

  11. Mwanga HH, Dalvie MA, Singh TS, Channa K, Jeebhay MF (2016) Relationship between pesticide metabolites, cytokine patterns, and asthma-related outcomes in rural women workers. Int J Environ Res Public Health 13:E957

    Google Scholar 

  12. Santos R, Piccoli C, Cremonese C, Freire C (2019) Thyroid and reproductive hormones in relation to pesticide use in an agricultural population in Southern Brazil. Environ Res 173:221–231

    CAS  Google Scholar 

  13. Shrestha S, Parks CG, Goldner WS, Kamel F, Umbach DM, Ward MH, Lerro CC, Koutros S, Hofmann JN, Beane Freeman LE, Sandler DP (2019) Pesticide use and incident hyperthyroidism in farmers in the agricultural health study. Occup Environ Med 76:332–335

    Google Scholar 

  14. Shrestha S, Parks CG, Goldner WS, Kamel F, Umbach DM, Ward MH, Lerro CC, Koutros S, Hofmann JN, Beane Freeman LE, Sandler DP (2018) Incident thyroid disease in female spouses of private pesticide applicators. Environ Int 118:282–292

    CAS  Google Scholar 

  15. Shrestha S, Parks CG, Goldner WS, Kamel F, Umbach DM, Ward MH, Lerro CC, Koutros S, Hofmann JN, Beane Freeman LE, Sandler DP (2018) Pesticide use and incident hypothyroidism in pesticide applicators in the agricultural health study. Environ Health Perspect 126:97008

    CAS  Google Scholar 

  16. Lerro CC, Beane Freeman LE, DellaValle CT, Kibriya MG, Aschebrook-Kilfoy B, Jasmine F, Koutros S, Parks CG, Sandler DP, Alavanja MCR, Hofmann JN, Ward MH (2018) Occupational pesticide exposure and subclinical hypothyroidism among male pesticide applicators. Occup Environ Med 75:79–89

    Google Scholar 

  17. Jain RB (2016) Variability in the levels of 3-phenoxybenzoic acid by age, gender, and race/ethnicity for the period of 2001-2002 versus 2009-2010 and its association with thyroid function among general US population. Environ Sci Pollut Res Int 23:6934–6939

    CAS  Google Scholar 

  18. Zhang J, Yoshinaga J, Hisada A, Shiraishi H, Shimodaira K, Okai T, Koyama M, Watanabe N, Suzuki E, Shirakawa M, Noda Y, Komine Y, Ariki N, Kato N (2014) Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates. Sci Total Environ 488–489:275–279

    Google Scholar 

  19. Zhang J, Hisada A, Yoshinaga J, Shiraishi H, Shimodaira K, Okai T, Noda Y, Shirakawa M, Kato N (2013) Exposure to pyrethroids insecticides and serum levels of thyroid-related measures in pregnant women. Environ Res 127:16–21

    CAS  Google Scholar 

  20. Al-Hussaini TK, Abdelaleem AA, Elnashar I, Shabaan OM, Mostafa R, El-Baz MAH, El-Deek SEM, Farghaly TA (2018) The effect of follicular fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome. Eur J Obstet Gynecol Reprod Biol 220:39–43

    CAS  Google Scholar 

  21. Hu Y, Ji L, Zhang Y, Shi R, Han W, Tse LA, Pan R, Wang Y, Ding G, Xu J, Zhang Q, Gao Y, Tian Y (2018) Organophosphate and pyrethroid pesticide exposures measured before conception and associations with time to pregnancy in Chinese couples enrolled in the Shanghai birth cohort. Environ Health Perspect 126:077001

    Google Scholar 

  22. Li C, Cao M, Ma L, Ye X, Song Y, Pan W, Xu Z, Ma X, Lan Y, Chen P, Liu W, Liu J, Zhou J (2018) Pyrethroid pesticide exposure and risk of primary ovarian insufficiency in Chinese women. Environ Sci Technol 52:3240–3248

    CAS  Google Scholar 

  23. Ye X, Pan W, Zhao Y, Zhao S, Zhu Y, Liu W, Liu J (2017) Association of pyrethroids exposure with onset of puberty in Chinese girls. Environ Pollut (Barking, Essex: 1987) 227:606–612

    Google Scholar 

  24. Whitworth KW, Baird DD, Steiner AZ, Bornman RM, Travlos GS, Wilson RE, Longnecker MP (2015) Anti-Mullerian hormone and lifestyle, reproductive, and environmental factors among women in rural South Africa. Epidemiology (Cambridge, Mass) 26:429–435

    Google Scholar 

  25. Panuwet P, Ladva C, Barr DB, Prapamontol T, Meeker JD, D’Souza PE, Maldonado H, Ryan PB, Robson MG (2018) Investigation of associations between exposures to pesticides and testosterone levels in Thai farmers. Arch Environ Occup Health 73:205–218

    CAS  Google Scholar 

  26. Ye X, Pan W, Zhao S, Zhao Y, Zhu Y, Liu J, Liu W (2017) Relationships of pyrethroid exposure with gonadotropin levels and pubertal development in Chinese boys. Environ Sci Technol 51:6379–6386

    CAS  Google Scholar 

  27. Jurewicz J, Radwan M, Sobala W, Radwan P, Jakubowski L, Wielgomas B, Ligocka D, Brzeznicki S, Hanke W (2016) Exposure to widespread environmental endocrine disrupting chemicals and human sperm sex ratio. Environ Pollut (Barking, Essex: 1987) 213:732–740

    Google Scholar 

  28. Jurewicz J, Radwan M, Wielgomas B, Sobala W, Piskunowicz M, Radwan P, Bochenek M, Hanke W (2015) The effect of environmental exposure to pyrethroids and DNA damage in human sperm. Syst Biol Reprod Med 61:37–43

    CAS  Google Scholar 

  29. Radwan M, Jurewicz J, Wielgomas B, Piskunowicz M, Sobala W, Radwan P, Jakubowski L, Hawula W, Hanke W (2015) The association between environmental exposure to pyrethroids and sperm aneuploidy. Chemosphere 128:42–48

    CAS  Google Scholar 

  30. Imai K, Yoshinaga J, Yoshikane M, Shiraishi H, Mieno MN, Yoshiike M, Nozawa S, Iwamoto T (2014) Pyrethroid insecticide exposure and semen quality of young Japanese men. Reprod Toxicol (Elmsford, NY) 43:38–44

    Google Scholar 

  31. Radwan M, Jurewicz J, Wielgomas B, Sobala W, Piskunowicz M, Radwan P, Hanke W (2014) Semen quality and the level of reproductive hormones after environmental exposure to pyrethroids. J Occup Environ Med 56:1113–1119

    CAS  Google Scholar 

  32. Yoshinaga J, Imai K, Shiraishi H, Nozawa S, Yoshiike M, Mieno MN, Andersson AM, Iwamoto T (2014) Pyrethroid insecticide exposure and reproductive hormone levels in healthy Japanese male subjects. Andrology 2:416–420

    CAS  Google Scholar 

  33. Chevrier J, Rauch S, Crause M, Obida M, Gaspar F, Bornman R, Eskenazi B (2019) Associations of maternal exposure to dichlorodiphenyltrichloroethane and pyrethroids with birth outcomes among participants in the Venda Health Examination of Mothers, Babies and their Environment residing in an area sprayed for malaria control. Am J Epidemiol 188:130–140

    Google Scholar 

  34. Coker E, Chevrier J, Rauch S, Bradman A, Obida M, Crause M, Bornman R, Eskenazi B (2018) Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort. Environ Int 113:122–132

    CAS  Google Scholar 

  35. Dalsager L, Christensen LE, Kongsholm MG, Kyhl HB, Nielsen F, Schoeters G, Jensen TK, Andersen HR (2018) Associations of maternal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-D with birth outcomes and anogenital distance at 3 months in the Odense Child Cohort. Reprod Toxicol (Elmsford, NY) 76:53–62

    Google Scholar 

  36. Ling C, Liew Z, von Ehrenstein OS, Heck JE, Park AS, Cui X, Cockburn M, Wu J, Ritz B (2018) Prenatal exposure to ambient pesticides and preterm birth and term low birthweight in agricultural regions of California. Toxics 6:E41

    Google Scholar 

  37. Shaw GM, Yang W, Roberts EM, Kegley SE, Stevenson DK, Carmichael SL, English PB (2018) Residential agricultural pesticide exposures and risks of spontaneous preterm birth. Epidemiology 29:8–21

    Google Scholar 

  38. Ding G, Cui C, Chen L, Gao Y, Zhou Y, Shi R, Tian Y (2015) Prenatal exposure to pyrethroid insecticides and birth outcomes in rural Northern China. J Expo Sci Environ Epidemiol 25:264–270

    CAS  Google Scholar 

  39. Rappazzo KM, Warren JL, Davalos AD, Meyer RE, Sanders AP, Brownstein NC, Luben TJ (2019) Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003-2005 North Carolina birth cohort. Birth Defects Res 111:312–323

    CAS  Google Scholar 

  40. Carmichael SL, Yang W, Roberts E, Kegley SE, Brown TJ, English PB, Lammer EJ, Shaw GM (2016) Residential agricultural pesticide exposures and risks of selected birth defects among offspring in the San Joaquin Valley of California. Birth Defects Res A Clin Mol Teratol 106:27–35

    CAS  Google Scholar 

  41. Carmichael SL, Yang W, Roberts E, Kegley SE, Padula AM, English PB, Lammer EJ, Shaw GM (2014) Residential agricultural pesticide exposures and risk of selected congenital heart defects among offspring in the San Joaquin Valley of California. Environ Res 135:133–138

    CAS  Google Scholar 

  42. Shaw GM, Yang W, Roberts E, Kegley SE, Padula A, English PB, Carmichael SL (2014) Early pregnancy agricultural pesticide exposures and risk of gastroschisis among offspring in the San Joaquin Valley of California. Birth Defects Res A Clin Mol Teratol 100:686–694

    CAS  Google Scholar 

  43. Yang W, Carmichael SL, Roberts EM, Kegley SE, Padula AM, English PB, Shaw GM (2014) Residential agricultural pesticide exposures and risk of neural tube defects and orofacial clefts among offspring in the San Joaquin Valley of California. Am J Epidemiol 179:740–748

    Google Scholar 

  44. Huang J, Eskenazi B, Bornman R, Rauch S, Chevrier J (2018) Maternal peripartum serum DDT/E and urinary pyrethroid metabolite concentrations and child infections at 2 years in the VHEMBE birth cohort. Environ Health Perspect 126:067006

    Google Scholar 

  45. Ismail AA, Almalki M, Agag A, Solan YM, Bani IA (2018) Pesticide application and Khat chewing as predictors of the neurological health outcomes among pesticide applicators in a Vector Control Unit, Saudi Arabia. Int J Occup Environ Med 9:32–44

    Google Scholar 

  46. Shrestha S, Kamel F, Umbach DM, Fan Z, Beane Freeman LE, Koutros S, Alavanja M, Blair A, Sandler DP, Chen H (2018) Factors associated with dream enacting behaviors among US farmers. Parkinsonism Relat Disord 57:9–15

    Google Scholar 

  47. Hansen MRH, Jors E, Lander F, Condarco G, Debes F, Bustillos NT, Schlunssen V (2017) Neurological deficits after long-term pyrethroid exposure. Environ Health Insights 11:1178630217700628

    Google Scholar 

  48. Huang X, Zhang C, Hu R, Li Y, Yin Y, Chen Z, Cai J, Cui F (2016) Association between occupational exposures to pesticides with heterogeneous chemical structures and farmer health in China. Sci Rep 6:25190

    CAS  Google Scholar 

  49. Zhang C, Sun Y, Hu R, Huang J, Huang X, Li Y, Yin Y, Chen Z (2018) A comparison of the effects of agricultural pesticide uses on peripheral nerve conduction in China. Sci Rep 8:9621

    Google Scholar 

  50. Campos Y, Dos Santos Pinto da Silva V, Sarpa Campos de Mello M, Barros Otero U (2016) Exposure to pesticides and mental disorders in a rural population of Southern Brazil. Neurotoxicology 56:7–16

    CAS  Google Scholar 

  51. Furlong M, Tanner CM, Goldman SM, Bhudhikanok GS, Blair A, Chade A, Comyns K, Hoppin JA, Kasten M, Korell M, Langston JW, Marras C, Meng C, Richards M, Ross GW, Umbach DM, Sandler DP, Kamel F (2015) Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson’s disease. Environ Int 75:144–150

    CAS  Google Scholar 

  52. Motsoeneng PM, Dalvie MA (2015) Relationship between urinary pesticide residue levels and neurotoxic symptoms among women on farms in the Western Cape, South Africa. Int J Environ Res Public Health 12:6281–6299

    CAS  Google Scholar 

  53. Eskenazi B, An S, Rauch SA, Coker ES, Maphula A, Obida M, Crause M, Kogut KR, Bornman R, Chevrier J (2018) Prenatal exposure to DDT and pyrethroids for malaria control and child neurodevelopment: the VHEMBE cohort, South Africa. Environ Health Perspect 126:047004

    Google Scholar 

  54. Coker E, Gunier R, Bradman A, Harley K, Kogut K, Molitor J, Eskenazi B (2017) Association between pesticide profiles used on agricultural fields near maternal residences during pregnancy and IQ at age 7 years. Int J Environ Res Public Health 14:E506

    Google Scholar 

  55. Furlong MA, Barr DB, Wolff MS, Engel SM (2017) Prenatal exposure to pyrethroid pesticides and childhood behavior and executive functioning. Neurotoxicology 62:231–238

    CAS  Google Scholar 

  56. Gunier RB, Bradman A, Harley KG, Kogut K, Eskenazi B (2017) Prenatal residential proximity to agricultural pesticide use and IQ in 7-year-old children. Environ Health Perspect 125:057002

    Google Scholar 

  57. Hisada A, Yoshinaga J, Zhang J, Kato T, Shiraishi H, Shimodaira K, Okai T, Ariki N, Komine Y, Shirakawa M, Noda Y, Kato N (2017) Maternal exposure to pyrethroid insecticides during pregnancy and infant development at 18 months of age. Int J Environ Res Public Health 14:E52

    Google Scholar 

  58. Viel JF, Rouget F, Warembourg C, Monfort C, Limon G, Cordier S, Chevrier C (2017) Behavioural disorders in 6-year-old children and pyrethroid insecticide exposure: the PELAGIE mother-child cohort. Occup Environ Med 74:275–281

    Google Scholar 

  59. Fluegge KR, Nishioka M, Wilkins JR 3rd (2016) Effects of simultaneous prenatal exposures to organophosphate and synthetic pyrethroid insecticides on infant neurodevelopment at three months of age. J Environ Toxicol Public Health 1:60–73

    Google Scholar 

  60. Watkins DJ, Fortenberry GZ, Sanchez BN, Barr DB, Panuwet P, Schnaas L, Osorio-Valencia E, Solano-Gonzalez M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM, Meeker JD (2016) Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: distribution and relationships with child neurodevelopment. Environ Res 147:307–313

    CAS  Google Scholar 

  61. Viel JF, Warembourg C, Le Maner-Idrissi G, Lacroix A, Limon G, Rouget F, Monfort C, Durand G, Cordier S, Chevrier C (2015) Pyrethroid insecticide exposure and cognitive developmental disabilities in children: the PELAGIE mother-child cohort. Environ Int 82:69–75

    CAS  Google Scholar 

  62. van Wendel de Joode B, Mora AM, Lindh CH, Hernandez-Bonilla D, Cordoba L, Wesseling C, Hoppin JA, Mergler D (2016) Pesticide exposure and neurodevelopment in children aged 6-9 years from Talamanca, Costa Rica. Cortex 85:137–150

    Google Scholar 

  63. Wang N, Huang M, Guo X, Lin P (2016) Urinary metabolites of organophosphate and pyrethroid pesticides and neurobehavioral effects in Chinese children. Environ Sci Technol 50:9627–9635

    CAS  Google Scholar 

  64. Fiedler N, Rohitrattana J, Siriwong W, Suttiwan P, Ohman Strickland P, Ryan PB, Rohlman DS, Panuwet P, Barr DB, Robson MG (2015) Neurobehavioral effects of exposure to organophosphates and pyrethroid pesticides among Thai children. Neurotoxicology 48:90–99

    CAS  Google Scholar 

  65. Oulhote Y, Bouchard MF (2013) Urinary metabolites of organophosphate and pyrethroid pesticides and behavioral problems in Canadian children. Environ Health Perspect 121:1378–1384

    Google Scholar 

  66. Richardson JR, Taylor MM, Shalat SL, Guillot TS 3rd, Caudle WM, Hossain MM, Mathews TA, Jones SR, Cory-Slechta DA, Miller GW (2015) Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB J 29:1960–1972

    CAS  Google Scholar 

  67. Wagner-Schuman M, Richardson JR, Auinger P, Braun JM, Lanphear BP, Epstein JN, Yolton K, Froehlich TE (2015) Association of pyrethroid pesticide exposure with attention-deficit/hyperactivity disorder in a nationally representative sample of U.S. children. Environ Health 14:44

    Google Scholar 

  68. Quiros-Alcala L, Mehta S, Eskenazi B (2014) Pyrethroid pesticide exposure and parental report of learning disability and attention deficit/hyperactivity disorder in U.S. children: NHANES 1999-2002. Environ Health Perspect 122:1336–1342

    CAS  Google Scholar 

  69. von Ehrenstein OS, Ling C, Cui X, Cockburn M, Park AS, Yu F, Wu J, Ritz B (2019) Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study. BMJ 364:l962

    Google Scholar 

  70. Schmidt RJ, Kogan V, Shelton JF, Delwiche L, Hansen RL, Ozonoff S, Ma CC, McCanlies EC, Bennett DH, Hertz-Picciotto I, Tancredi DJ, Volk HE (2017) Combined prenatal pesticide exposure and folic acid intake in relation to autism spectrum disorder. Environ Health Perspect 125:097007

    Google Scholar 

  71. Hicks SD, Wang M, Fry K, Doraiswamy V, Wohlford EM (2017) Neurodevelopmental delay diagnosis rates are increased in a region with aerial pesticide application. Front Pediatr 5:116

    Google Scholar 

  72. Domingues VF, Nasuti C, Piangerelli M, Correia-Sa L, Ghezzo A, Marini M, Abruzzo PM, Visconti P, Giustozzi M, Rossi G, Gabbianelli R (2016) Pyrethroid pesticide metabolite in urine and microelements in hair of children affected by autism spectrum disorders: a preliminary investigation. Int J Environ Res Public Health 13:388

    Google Scholar 

  73. Shelton JF, Geraghty EM, Tancredi DJ, Delwiche LD, Schmidt RJ, Ritz B, Hansen RL, Hertz-Picciotto I (2014) Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study. Environ Health Perspect 122:1103–1109

    Google Scholar 

  74. Roberts JR, Dawley EH, Reigart JR (2019) Children’s low-level pesticide exposure and associations with autism and ADHD: a review. Pediatr Res 85:234–241

    Google Scholar 

  75. Rossignol DA, Genuis SJ, Frye RE (2014) Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 4:e360

    CAS  Google Scholar 

  76. Bailey HD, Infante-Rivard C, Metayer C, Clavel J, Lightfoot T, Kaatsch P, Roman E, Magnani C, Spector LG, Th Petridou E, Milne E, Dockerty JD, Miligi L, Armstrong BK, Rudant J, Fritschi L, Simpson J, Zhang L, Rondelli R, Baka M, Orsi L, Moschovi M, Kang AY, Schuz J (2015) Home pesticide exposures and risk of childhood leukemia: findings from the childhood leukemia international consortium. Int J Cancer 137:2644–2663

    CAS  Google Scholar 

  77. Chen S, Gu S, Wang Y, Yao Y, Wang G, Jin Y, Wu Y (2016) Exposure to pyrethroid pesticides and the risk of childhood brain tumors in East China. Environ Pollut (Barking, Essex: 1987) 218:1128–1134

    CAS  Google Scholar 

  78. Hyland C, Gunier RB, Metayer C, Bates MN, Wesseling C, Mora AM (2018) Maternal residential pesticide use and risk of childhood leukemia in Costa Rica. Int J Cancer 143:1295–1304

    CAS  Google Scholar 

  79. Rios P, Bailey HD, Lacour B, Valteau-Couanet D, Michon J, Bergeron C, Boutroux H, Defachelles AS, Gambart M, Sirvent N, Thebaud E, Ducassou S, Orsi L, Clavel J (2017) Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE). Cancer Causes Control 28:1125–1132

    Google Scholar 

  80. Van Maele-Fabry G, Gamet-Payrastre L, Lison D (2017) Residential exposure to pesticides as risk factor for childhood and young adult brain tumors: a systematic review and meta-analysis. Environ Int 106:69–90

    Google Scholar 

  81. Van Maele-Fabry G, Gamet-Payrastre L, Lison D (2019) Household exposure to pesticides and risk of leukemia in children and adolescents: updated systematic review and meta-analysis. Int J Hyg Environ Health 222:49–67

    Google Scholar 

  82. Vidart d’Egurbide Bagazgoitia N, Bailey HD, Orsi L, Lacour B, Guerrini-Rousseau L, Bertozzi AI, Leblond P, Faure-Conter C, Pellier I, Freycon C, Doz F, Puget S, Ducassou S, Clavel J (2018) Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE). Int J Cancer 142:489–497

    Google Scholar 

  83. Alavanja MC, Hofmann JN, Lynch CF, Hines CJ, Barry KH, Barker J, Buckman DW, Thomas K, Sandler DP, Hoppin JA, Koutros S, Andreotti G, Lubin JH, Blair A, Beane Freeman LE (2014) Non-hodgkin lymphoma risk and insecticide, fungicide and fumigant use in the agricultural health study. PLoS One 9:e109332

    Google Scholar 

  84. Alexander M, Koutros S, Bonner MR, Barry KH, Alavanja MCR, Andreotti G, Byun HM, Chen L, Beane Freeman LE, Hofmann JN, Kamel F, Moore LE, Baccarelli A, Rusiecki J (2017) Pesticide use and LINE-1 methylation among male private pesticide applicators in the agricultural health study. Environ Epigenet 3:dvx005

    Google Scholar 

  85. Boffetta P, Desai V (2018) Exposure to permethrin and cancer risk: a systematic review. Crit Rev Toxicol 48:433–442

    CAS  Google Scholar 

  86. Bonner MR, Freeman LE, Hoppin JA, Koutros S, Sandler DP, Lynch CF, Hines CJ, Thomas K, Blair A, Alavanja MC (2017) Occupational exposure to pesticides and the incidence of lung Cancer in the agricultural health study. Environ Health Perspect 125:544–551

    Google Scholar 

  87. Engel LS, Werder E, Satagopan J, Blair A, Hoppin JA, Koutros S, Lerro CC, Sandler DP, Alavanja MC, Beane Freeman LE (2017) Insecticide use and breast cancer risk among farmers’ wives in the agricultural health study. Environ Health Perspect 125:097002

    Google Scholar 

  88. Koutros S, Silverman DT, Alavanja MC, Andreotti G, Lerro CC, Heltshe S, Lynch CF, Sandler DP, Blair A, Beane Freeman LE (2016) Occupational exposure to pesticides and bladder cancer risk. Int J Epidemiol 45:792–805

    Google Scholar 

  89. Leon ME, Schinasi LH, Lebailly P, Beane Freeman LE, Nordby KC, Ferro G, Monnereau A, Brouwer M, Tual S, Baldi I, Kjaerheim K, Hofmann JN, Kristensen P, Koutros S, Straif K, Kromhout H, Schuz J (2019) Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium. Int J Epidemiol 48:1519–1535

    Google Scholar 

  90. Han J, Zhou L, Luo M, Liang Y, Zhao W, Wang P, Zhou Z, Liu D (2017) Nonoccupational exposure to pyrethroids and risk of coronary heart disease in the Chinese population. Environ Sci Technol 51:664–670

    CAS  Google Scholar 

  91. Lee KS, Lee YA, Lee YJ, Shin CH, Lim YH, Hong YC (2019) The relationship of urinary 3-phenoxybenzoic acid concentrations in utero and during childhood with adiposity in 4-year-old children. Environ Res 172:446–453

    CAS  Google Scholar 

  92. Yoo M, Lim YH, Kim T, Lee D, Hong YC (2016) Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1st Korean National Environmental Health Survey. Ann Occup Environ Med 28:2

    Google Scholar 

  93. Cortes-Iza SC, Rodriguez AI, Prieto-Suarez E (2017) Assessment of hematological parameters in workers exposed to organophosphorus pesticides, carbamates and pyrethroids in Cundinamarca 2016-2017. Rev Salud Publica (Bogota) 19:468–474

    Google Scholar 

  94. Ali T, Ismail M, Asad F, Ashraf A, Waheed U, Khan QM (2018) Pesticide genotoxicity in cotton picking women in Pakistan evaluated using comet assay. Drug Chem Toxicol 41:213–220

    CAS  Google Scholar 

  95. El Okda ES, Abdel-Hamid MA, Hamdy AM (2017) Immunological and genotoxic effects of occupational exposure to alpha-cypermethrin pesticide. Int J Occup Med Environ Health 30:603–615

    Google Scholar 

  96. Vidi PA, Anderson KA, Chen H, Anderson R, Salvador-Moreno N, Mora DC, Poutasse C, Laurienti PJ, Daniel SS, Arcury TA (2017) Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children. Mutat Res 822:27–33

    CAS  Google Scholar 

  97. Zepeda-Arce R, Rojas-Garcia AE, Benitez-Trinidad A, Herrera-Moreno JF, Medina-Diaz IM, Barron-Vivanco BS, Villegas GP, Hernandez-Ochoa I, Solis Heredia MJ, Bernal-Hernandez YY (2017) Oxidative stress and genetic damage among workers exposed primarily to organophosphate and pyrethroid pesticides. Environ Toxicol 32:1754–1764

    CAS  Google Scholar 

  98. Meyer A, Sandler DP, Beane Freeman LE, Hofmann JN, Parks CG (2017) Pesticide exposure and risk of rheumatoid arthritis among licensed male pesticide applicators in the agricultural health study. Environ Health Perspect 125:077010

    Google Scholar 

  99. Hansen MR, Jors E, Lander F, Condarco G, Schlunssen V (2014) Is cumulated pyrethroid exposure associated with prediabetes? A cross-sectional study. J Agromedicine 19:417–426

    Google Scholar 

  100. Park J, Park SK, Choi YH (2018) Environmental pyrethroid exposure and diabetes in U.S. adults. Environ Res 172:399–407

    Google Scholar 

  101. Martenies SE, Perry MJ (2013) Environmental and occupational pesticide exposure and human sperm parameters: a systematic review. Toxicology 307:66–73

    CAS  Google Scholar 

  102. Zamkowska D, Karwacka A, Jurewicz J, Radwan M (2018) Environmental exposure to non-persistent endocrine disrupting chemicals and semen quality: an overview of the current epidemiological evidence. Int J Occup Med Environ Health 31:377–414

    Google Scholar 

  103. Ye M, Beach J, Martin JW, Senthilselvan A (2017) Pesticide exposures and respiratory health in general populations. J Environ Sci (China) 51:361–370

    Google Scholar 

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Authors and Affiliations

  1. Institut National de Recherche et de Sécurité, Vandoeuvre-les-Nancy, France

    Anne-Marie Saillenfait

  2. Institut National de Recherche et de Sécurité, Paris, France

    Stéphane Malard

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  1. Anne-Marie Saillenfait
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  2. Stéphane Malard
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Correspondence to Anne-Marie Saillenfait .

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  1. Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain

    Ethel Eljarrat

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Saillenfait, AM., Malard, S. (2020). Human Risk Associated with Long-Term Exposure to Pyrethroid Insecticides. In: Eljarrat, E. (eds) Pyrethroid Insecticides. The Handbook of Environmental Chemistry, vol 92. Springer, Cham. https://doi.org/10.1007/698_2019_427

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