Abstract
Human exposure to major classes of personal care products (PCPs) that include disinfectants (e.g. triclosan), fragrances (e.g. musks), insect repellents (e.g. DEET), preservatives (e.g. parabens), and UV filters (e.g. benzophenones) has been reviewed. Concentrations of these toxicants in human matrices (blood, urine, or tissues) have been compiled, alongside with relevant health implications.
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References
Yusa V, Ye X, Calafat AM (2012) Methods for the determination of biomarkers of exposure to emerging pollutants in human specimens. Trends Anal Chem 38:129–142
Asimakopoulos AG, Wang L, Thomaidis NS, Kannan K (2014) A multi-class bioanalytical methodology for the determination of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters, benzophenone-type ultraviolet filters, triclosan, and triclocarban in human urine by liquid chromatography–tandem mass spectrometry. J Chromatogr A 1324:141–148
Asimakopoulos AG, Thomaidis NS, Kannan K (2014) Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. Sci Total Environ 470–471:1243–1249
Dann AB, Hontela A (2011) Triclosan: environmental exposure, toxicity and mechanisms of action. J Appl Toxicol 31:285–311
Fang JL, Stingley RL, Beland FA, Harrouk W, Lumpkins DL, Howard P (2010) Occurrence, efficacy, metabolism, and toxicity of triclosan. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28:147–171
Mortensen ME, Calafat AM, Ye X, Wong L-Y, Wright DJ, Pirkle JL, Merrill LS, Moye J (2014) Urinary concentrations of environmental phenols in pregnant women in a pilot study of the National Children's Study. Environ Res 129:32–38
Provencher G, Bérubé R, Dumas P, Bienvenu J-F, Gaudreau É, Bélangera P, Ayotte P (2014) Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography–tandem mass spectrometry. J Chromatogr A 1348:97–104
Clayton EMR, Todd M, Dowd JB, Aie AE (2011) The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003–2006. Environ Health Persp 119:390–396
Kim K, Park H, Yang W, Lee JH (2011) Urinary concentrations of bisphenol A and triclosan and associations with demographic factors in the Korean population. Environ Res 111:1280–1285
Pirard C, Sagot C, Deville M, Dubois N, Charlier C (2012) Urinary levels of bisphenol A, triclosan and 4-nonylphenol in a general Belgian population. Environ Int 48:78–83
Lankester J, Patel C, Cullen MR, Ley C, Parsonnet J (2013) Urinary triclosan is associated with elevated body mass index in. NHANES PLoS ONE 8(11):1–7
Meeker JD, Cantonwine DE, Rivera-González LO, Ferguson KK, Mukherjee B, Calafat AM, Ye X, Del Toro LVA, Crespo-Hernández N, Jiménez-Vélez B, Alshawabkeh AN, Cordero JF (2013) Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico. Environ Sci Technol 47:3439–3447
Li X, Ying GG, Zhao JL, Chen ZF, Lai HJ, Su HC (2013) 4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China and the effects of drinking these bottles materials on levels. Environ Int 52:81–86
Allmyr M, Harden F, Toms LML, Mueller JF, McLachlan MS, Adolfsson-Erici M, Sandborgh-Englund G (2008) The influence of age and gender on triclosan concentrations in Australian human blood serum. Sci Total Environ 393:162–167
Allmyr M, Adolfsson-Erici M, McLachlan MS, Sandborgh-Englund G (2006) Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci Total Environ 372:87–93
Pycke BFG, Geer LA, Dalloul M, Abulafia O, Jenck A, Halden RU (2014) Human fetal exposure to triclosan and triclocarban in an urban population from Brooklyn, New York. Environ Sci Technol 48(15):8831–8838
Jiménez-Díaz I, Zafra-Gómez A, Ballesteros O, Navalón A (2014) Analytical methods for the determination of personal care products in human samples. An overview. Talanta 129:448–458
Covaci A, Geens T, Roosens L, Ali N, Van den Eede N, Ionas AC, Malarvannan G, Dirtu AC (2012) Human exposure and health risks to emerging organic contaminants In: Barceló D (vol ed) Emerging organic contaminants and human health. The Handbook of Environmental Chemistry. Springer-Verlag, Berlin, Heidelberg, pp 243–305
Wang H, Zhang J, Gao F, Yang Y, Duan H, Wu Y, Berset JD, Shao B (2011) Simultaneous analysis of synthetic musks and triclosan in human breast milk by gas chromatography tandem mass spectrometry. J Chromatogr B 879:1861–1869
Zhang X, Liang G, Zeng X, Zhou J, Sheng G, Fu J (2011) Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China. J Environ Sci 23:983–990
Schlumpf M, Kypke K, Wittassek M, Angerer J, Mascher H, Mascher D, Vökt C, Birchler M, Lichtensteiger W (2010) Exposure patterns of UV filters, fragrances, parabens, phthalates, organochlor pesticides, PBDEs, and PCBs in human milk: correlation of UV filters with use of cosmetics. Chemosphere 81:1171–1183
Kang CS, Lee JH, Kim SK, Lee KT, Lee JS, Park PS, Yun SH, Kannan K, Yoo YW, Ha JY, Lee SW (2010) Polybrominated diphenyl ethers and synthetic musks in umbilical cord Serum, maternal serum, and breast milk from Seoul, South Korea. Chemosphere 80:116–122
Reiner JL, Wong CM, Arcaro KF, Kannan K (2007) Synthetic musk fragrances in human milk from the United States. Environ Sci Technol 41:3815–3820
Hu Z, Shi Y, Niu H, Cai Y, Jia G, Wu Y (2010) Occurrence of synthetic musk fragrances in human blood from 11 cities in China. Environ Toxicol Chem 29:1877–1882
Hutter HP, Wallner P, Hartl W, Uhl M, Lorbeer G, Gminski R, Mersch-Sundermann V, Kundi M (2010) Higher blood concentrations of synthetic musks in women above fifty years than in younger women. Int J Hyg Environ Health 213:124–130
Hutter HP, Wallner P, Moshammer H, Hartl W, Sattelberger R, Lorbeer G, Kundi M (2005) Blood concentrations of polycyclic musks in healthy young adults. Chemosphere 59:487–492
Washam C (2005) A Whiff of danger synthetic musks may encourage toxic bioaccumulation. Environ Health Perspect 113(1):A50
Pouillot A, Polla BS, Polla AS (2006) Conservateurs en cosmetology mise au point sur les parabenes. J Méd Esthét Chir Dermatol 33:187–190
Rastogi SC, Schouten A, De Kruijf N, Weijland JW (1995) Contents of methyl-, ethyl-, propyl-, butyl- and benzylparaben in cosmetic products. Contact Dermatitis 32:28–30
Błędzka D, Gromadzińska J, Wąsowicz W (2014) Parabens. From environmental studies to human health. Environ Int 67:27–42
Meeker JD, Yang T, Ye X, Calafat AM, Hauser R (2011) Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage. Environ Health Perspect 119:252–257
Savage JH, Matsui EC, Wood R, Keet CA (2012) Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. J Allergy Clin Immunol 130:453–460
Wang L, Kannan K (2013) Alkyl protocatechuates as novel urinary biomarkers of exposure to p-hydroxybenzoic acid esters (parabens). Environ Int 59:27–32
Ye X, Bishop AM, Reidy JA, Needham LL, Calafat AM (2006) Parabens as urinary biomarkers of exposure in humans. Environ Health Perspect 114:1843–1846
Calafat AM, Ye X, Wong LY, Bishop AM, Needham LL (2010) Urinary concentrations of four parabens in the U.S. population: NHANES 2005–2006. Environ Health Perspect 118:679–685
Frederiksen H, Jørgensen N, Andersson A-M (2011) Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography–tandem mass spectrometry (LC–MS/MS). J Expo Sci Environ Epidemiol 21:262–271
Casas L, Fernández MF, Llop S, Guxens M, Ballester F, Olea N, Irurzun MB, Rodríguez LS, Riaño I, Tardón A, Vrijheid M, Calafat AM, Sunyer J (2011) Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children. Environ Int 37:858–866
Smith KW, Braun JM, Williams PL, Ehrlich S, Correia KF, Calafat AM, Ye X, Ford J, Keller M, Meeker JD, Hauser R (2012) Predictors and variability of urinary paraben concentrations in men and women, including before and during pregnancy. Environ Health Perspect 120:1538–1543
Koeppe ES, Ferguson KK, Colacino JA, Meeker JD (2013) Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007–2008. Sci Total Environ 445–446:299–305
Shirai S, Suzuki Y, Yoshinaga J, Shiraishi H, Mizumoto Y (2013) Urinary excretion of parabens in pregnant Japanese women. Reprod Toxicol 35:96–101
Kang S, Kim S, Park J, Kim HJ, Lee J, Choi G, Choi S, Kim S, Kim SY, Moon HB, Kim S, Kho YL, Choi K (2013) Urinary paraben concentrations among pregnant women and their matching newborn infants of Korea, and the association with oxidative stress biomarkers. Sci Total Environ 461–462:214–221
Ye X, Tao LJ, Needham LL, Calafat AM (2008) Automated on-line column-switching HPLC–MS/MS method for measuring environmental phenols and parabens in serum. Talanta 76:865–871
Dewalque L, Pirard C, Charlier C (2014) Measurement of urinary biomarkers of parabens, benzophenone-3, and phthalates in a Belgian population. Biomed Res Int 649314
Philippat C, Wolff MS, Calafat AM, Ye X, Bausell R, Meadows M, Stone J, Slama R, Engel SM (2013) Prenatal exposure to environmental phenols: Concentrations in amniotic fluid and variability in urinary concentrations during pregnancy. Environ Health Persp 121(10):1225–1231
Ma W-L, Wang L, Guo Y, Liu L-Y, Qi H, Zhu N-Z, Gao C-J, Li Y-F, Kannan K (2013) Urinary concentrations of parabens in Chinese young adults: Implications for human exposure. Arch Environ Contam Toxicol 65:611–618
Darbre PD, Aljarrah A, Miller WR, Coldham NG, Sauer MJ, Pope GS (2004) Concentrations of parabens in human breast tumours. J Appl Toxicol 24:5–13
Chisvert A, León-González Z, Tarazona I, Salvador A, Giokas D (2012) An overview of the analytical methods for the determination of organic ultraviolet filters in biological fluids and tissues. Anal Chim Acta 752:11–29
Kunisue T, Chen Z, Louis GMB, Sundaram R, Hediger ML, Sun L, Kannan K (2012) Urinary concentrations of benzophenone-type UV filters in U.S. women and their association with endometriosis. Environ Sci Technol 46:4624–4632
Buttke DE, Sircar K, Martin C (2012) Exposures to endocrine-disrupting chemicals and age of menarche in adolescent girls in NHANES (2003–2008). Environ Health Perspect 120(11):1613–1618
Wang L, Kannan K (2013) Characteristic profiles of benzophenone-3 and its derivatives in urine of children and adults from the United States and China. Environ Sci Technol 47(21):12532–12538
Zhang T, Sun H, Qin X, Wu Q, Zhang Y, Ma J, Kannan K (2013) Benzophenone-type UV filters in urine and blood from children, adults, and pregnant women in China: partitioning between blood and urine as well as maternal and fetal cord blood. Sci Total Environ 461–462:49–55
Calafat AM, Wong L-Y, Ye X, Reidy JA, Needham LL (2008) Concentrations of the sunscreen Agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003–2004. Environ Health Perspect 116(7):893–897
Brausch JM, Rand GM (2011) A review of personal care products in the aquatic environment: Environmental concentrations and toxicity. Chemosphere 82:1518–1532
Arcury TA, Grzywacz JG, Barr DB, Tapia J, Chen H, Quandt SA (2007) Pesticide urinary metabolite levels of children in Eastern North Carolina farmworker households. Environ Health Persp 115(7):1254–1260
Kuklenyik P, Baker SE, Bishop AM, Morales-A P, Calafat AM (2013) On-line solid phase extraction-high performance liquid chromatography–isotope dilution–tandem mass spectrometry approach to quantify N,N-diethyl-m-toluamide and oxidative metabolites in urine. Anal Chim Acta 787:267–273
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Asimakopoulos, A.G., Pasias, I.N., Kannan, K., Thomaidis, N.S. (2014). Human Exposure to Chemicals in Personal Care Products and Health Implications. In: Díaz‐Cruz, M., Barceló, D. (eds) Personal Care Products in the Aquatic Environment. The Handbook of Environmental Chemistry, vol 36. Springer, Cham. https://doi.org/10.1007/698_2014_301
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DOI: https://doi.org/10.1007/698_2014_301
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