Abstract
Concern regarding the environmental presence of sulfonamides and other species of antibiotics has focused mainly on the potential spread of antimicrobial resistance. However, their biological activity and high resistance to biodegradation may lead to long residence times in both water and soil matrices. Treated waters represent one of the main entrance pathways of these antimicrobials into the environment, and their potential impact in the aquatic ecosystems should be fully understood and investigated. Long-term ecological risks and unpredicted effects can result from unintentional exposure of different organisms and even human health could be negatively affected. This chapter aims to review the current knowlegde regarding sulfonamides ecotoxicity and to highlight the need for further data on the fate and ecotoxicity fo this family of antibiotics.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ternes T, Joss A (2006) Human Pharmaceuticals, Hormones and Fragrances: The Challenge of micropollutants in urban water management. IWA Publishing
Sarmah AK, Meyer MT, Boxall ABA (2006) Chemosphere 65:725
Besse JP, Garric J (2008) Toxicol Lett 176:104
Halling-Sörensen B, Nors Nielsen S, Lanzky PF, Ingerslev F, Holten Lützhöft HC, Jörgensen SE (1998) Chemosphere 36:357
Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Environ Sci Technol 36:1202
Halling-Sorensen B, Nors Nielsen S, Lanzky PF, Ingerslev F, Holten Luftzhoft HC, Jorgensen SE (1998) Chemosphere 36:357
Kümmerer KE (2004) Pharmaceuticals in the environment – Sources, fate, effects, and risks. 2nd edn. Springer, Berlin.
Thuy H, Nga L, Loan T (2011) Environ Sci Pollut Res 18:835
Chafer-Pericas C, Maquieira T, Puchades R, Company B, Miralles J, Moreno A (2010) Aquacult Res 41:e217
Hamscher G, Priess B, Nau H (2006) Arch Lebensmittelhyg 57:97
Pan X, Qiang Z, Ben W, Chen M (2011) Chemosphere 84:695
Wei R, Ge F, Huang S, Chen M, Wang R (2011) Chemosphere 82:1408
Pérez-Trallero E, Iglesias L (2003) Tetraciclinas, sulfamidas y metronidazol 21:520
Miao XS, Bishay F, Chen M, Metcalfe CD (2004) Environ Sci Technol 38:3533
Hamscher G, Priess B, Nau H (2006) Untersuchung von Teichwðssern und -sedimenten in niedersðchsischen aquakulturen im sommer 2005 auf sulfonamide und tetracycline 57:97
Cai-Ming T, Qiu-Xin H, Yi-Yi Y, Xian-Zhi P (2009) Fenxi Huaxue/Chinese J Anal Chem 37:1119
Díaz-Cruz MS, García-Galán MJ, Barceló D (2008) J Chromatogr A 1193:50
Tamtam F, Le Bot B, Dinh T, Mompelat S, Eurin J, Chevreuil M, Bonté P, Mouchel JM, Ayrault S (2011) J Soils Sediments 1
Kwon JW (2011) Bull Environ Contam Toxicol 87:40
García-Galán MJ, Garrido T, Fraile J, Ginebreda A, Díaz-Cruz MS, Barceló D (2010) J Hydrol 383:93
Campagnolo ER, Johnson KR, Karpati A, Rubin CS, Kolpin DW, Meyer MT, Esteban JE, Currier RW, Smith K, Thu KM, McGeehin M (2002) Sci Total Environ 299:89
Jia A, Hu J, Wu X, Peng H, Wu S, Dong Z (2011) Environ Toxicol Chem 30:1252
Massey LB, Haggard BE, Galloway JM, Loftin KA, Meyer MT, Green WR (2010) Ecol Eng 36:930
Brown KD, Kulis J, Thomson B, Chapman TH, Mawhinney DB (2006) Sci Total Environ 366:772
Joss A, Zabczynski S, Göbel A, Hoffmann B, Löffler D, McArdell CS, Ternes TA, Thomsen A, Siegrist H (2006) Water Res 40:1686
Ahel M, Mikac N, Cosovic B, Prohic E, Soukup V (1998) Water Sci Technol 37:203
Schwarzbauer J, Heim S, Brinker S, Littke R (2002) Water Res 36:2275
Topp E, Monteiro SC, Beck A, Coelho BB, Boxall ABA, Duenk PW, Kleywegt S, Lapen DR, Payne M, Sabourin L, Li H, Metcalfe CD (2008) Sci Total Environ 396:52
Haller MY, Müller SR, McArdell CS, Alder AC, Suter MJF (2002) J Chromatogr A 952:111
Parfitt KE (1999) The complete drug reference. 32nd edn. Pharmaceutical Press, London, UK
Motoyama M, Nakagawa S, Tanoue R, Sato Y, Nomiyama K, Shinohara R (2011) Chemosphere 84:432
Hamscher G, Pawelzick HT, Hoper H, Nau H (2005) Environ Toxicol Chem 24:861
Boxall ABA, Kolpin DW, Halling-Sorensen B, Tolls J (2003) Environ Sci Technol 37:286A
Schauss K, Focks A, Heuer H, Kotzerke A, Schmitt H, Thiele-Bruhn S, Smalla K, Wilke BM, Matthies M, Amelung W, Klasmeier J, Schloter M (2009) TRAC-Trend Anal Chem 28:612
Kotzerke A, Sharma S, Schauss K, Heuer H, Thiele-Bruhn S, Smalla K, Wilke BM, Schloter M (2008) Environ Pollut 153:315
Boxall ABA, Blackwell P, Cavallo R, Kay P, Tolls J (2002) Toxicol Lett 131:19
Kay P, Blackwell PA, Boxall ABA (2004) Environ Toxicol Chem 23:1136
Kay P, Blackwell PA, Boxall ABA (2005) Environ Pollut 134:333
Diaz-Cruz MS, Garcia-Galan MJ, Barcelo D (2008) J Chromatogr A 1193:50
Batt AL, Snow DD, Aga DS (2006) Chemosphere 64:1963
Lindsey ME, Meyer M, Thurman EM (2001) Anal Chem 73:4640
Sacher F, Lang FT, Brauch HJ, Blankenhorn I (2001) J Chromatogr A 938:199
Blackwell PA, Lutzhoft HCH, Ma HP, Halling-Sorensen B, Boxall ABA, Kay P (2004) J Chromatogr A 1045:111
Diaz-Cruz MS, Barcelo D (2006) Anal Bioanal Chem 386:973
Karthikeyan KG, Meyer MT (2006) Sci Total Environ 361:196
Batt AL, Aga DS (2005) Anal Chem 77:2940
Watanabe N, Bergamaschi BA, Loftin KA, Meyer MT, Harter T (2010) Environ Sci Technol 44:6591
García Galán MJ, Díaz-Cruz MS, Barceló D (2010) Talanta 81:355
García-Galán MJ, Díaz-Cruz MS, Barceló D (2011) Environ Int 37:462
Gobel A, McArdell CS, Joss A, Siegrist H, Giger W (2007) Sci Total Environ 372:361
Gobel A, McArdell CS, Suter MJF, Giger W (2004) Anal Chem 76:4756
Gros M, Petrovic M, Ginebreda A, Barceló D (2010) Environ Int 36:15
Reemtsma T, Weiss S, Mueller J, Petrovic M, González S, Barcelo D, Ventura F, Knepper TP (2006) Environ Sci Technol 40:5451
Lapen DR, Topp E, Metcalfe CD, Li H, Edwards M, Gottschall N, Bolton P, Curnoe W, Payne M, Beck A (2008) Sci Total Environ 399:50
Sabourin L, Beck A, Duenk PW, Kleywegt S, Lapen DR, Li H, Metcalfe CD, Payne M, Topp E (2009) Sci Total Environ 407:4596
García Galán MJ, Frömel T, Müller J, Peschka M, Knepper T, Díaz Cruz S, Barceló D (2011) Anal Bioanal Chem (submitted)
García Galán MJ, Díaz-Cruz MS, Barceló D (2011) Water Res (submitted)
Gros M, Petrovic M, Ginebreda A, Barcelo D (2010) Environ Int 36:15
García Galán MJ, Díaz-Cruz MS, Barceló D (2011) J Hazard Mat (submitted).
Garcia-Galan MJ, Villagrasa M, Silvia Diaz-Cruz M, Barcelo D (2010) Anal Bioanal Chem 397:1325
Tambosi JL, de Sena RF, Favier M, Gebhardt W, Jose HJ, Schroder HF, Moreira R (2010) Desalination 261:148
Tambosi JL, de Sena RF, Gebhardt W, Moreira R, Jose HJ, Schroder HF (2009) Ozone-Sci Eng 31:428
Radjenovic J, Petrovic M, Barceló D (2007) Anal Bioanal Chem 387:1365
Dodd MC, Huang CH (2004) Environ Sci Technol 38:5607
Huber MM, Canonica S, Park GY, Von Gunten U (2003) Environ Sci Technol 37:1016
Nakada N, Shinohara H, Murata A, Kiri K, Managaki S, Sato N, Takada H (2007) Water Res 41:4373
Kosutic K, Dolar D, Asperger D, Kunst B (2007) Sep Purif Technol 53:244
Garoma T, Umamaheshwar SK, Mumper A (2010) Chemosphere 79:814
Zwiener C (2007) Anal Bioanal Chem 387:1159
Thiele-Bruhn S, Aust MO (2004) Arch Environ Contam Toxicol 47:31
Kolpin DW, Skopec M, Meyer MT, Furlong ET, Zaugg SD (2004) Sci Total Environ 328:119
Zheng S, Qiu X, Chen B, Yu X, Liu Z, Zhong G, Li H, Chen M, Sun G, Huang H, Yu W, Freestone D (2011) Chemosphere 84(11): 1677
Lin AYC, Tsai YT (2009) Sci Total Environ 407:3793
Madureira TV, Barreiro JC, Rocha MJ, Rocha E, Cass QB, Tiritan ME (2010) Sci Total Environ 408:5513
Tamtam F, Mercier F, Le Bot B, Eurin J, Tuc Dinh Q, Clement M, Chevreuil M (2008) Sci Total Environ 393:84
Kim SC, Carlson K (2007) Environ Sci Technol 41:50
Tamtam F, Mercier F, Eurin J, Chevreuil M, Le Bot B (2009) Anal Bioanal Chem 393:1709
Wiegel S, Aulinger A, Brockmeyer R, Harms H, Löffler J, Reincke H, Schmidt R, Stachel B, von Tümpling W, Wanke A (2004) Chemosphere 57:107
Yang JF, Ying GG, Zhao JL, Tao R, Su HC, Chen F (2010) Sci Total Environ 408:3424
Löffler D, Römbke J, Meller M, Ternes TA (2005) Environ Sci Technol 39:5209
Ashton D, Hilton M, Thomas KV (2004) Sci Total Environ 333:167
Muñoz I, Lopez-Doval JC, Ricart M, Villagrasa M, Brix R, Geiszinger A, Ginebreda A, Guasch H, Lopez De Alda MJ, Romani AM, Sabater S, Barcelo D (2009) Environ Toxicol Chem 28:2706
Goñi-Urriza M, Capdepuy M, Arpin C, Raymond N, Pierre Caumette CQ (2000) Appl Environ Microbiol 66:125
Hoa PTP, Managaki S, Nakada N, Takada H, Shimizu A, Anh DH, Viet PH, Suzuki S (2011) Sci Total Environ 409:2894
Luo Y, Mao D, Rysz M, Zhou Q, Zhang H, Xu L, Alvarez PJJ (2010) Environ Sci Technol 44:7220
Costanzo SD, Murby J, Bates J (2005) Mar Pollut Bull 51:218
Storteboom H, Arabi M, Davis JG, Crimi B, Pruden A (2010) Environ Sci Technol 44:7397
Storteboom H, Arabi M, Davis JG, Crimi B, Pruden A (2010) Environ Sci Technol 44:1947
Barker-Reid F, Fox EM, Faggian R (2010) J Water Health 8:521
Heuer H, Schmitt H, Smalla K (2011) Curr Opin Microbiol 14:236
Schmitt H, Haapakangas H, van Beelen P (2005) Soil Biol Biochem 37:1882
Halling-Sorensen B, Sengelov G, Ingerslev F, Jensen LB (2003) Arch Environ Contam Toxicol 44:7
Sengelov G, Agerso Y, Halling-Sorensen B, Baloda SB, Andersen JS, Jensen LB (2003) Environ Int 28:587
Kay P, Blackwell PA, Boxall ABA (2005) Chemosphere 60:497
Kay P, Blackwell PA, Boxall ABA (2005) Chemosphere 59:951
Stoob K, Singer HP, Mueller SR, Schwarzenbach RP, Stamm CH (2007) Environ Sci Technol 41:7349
Tappe W, Zarfl C, Kummer S, Burauel P, Vereecken H, Groeneweg J (2008) Chemosphere 72:836
Zarfl C, Matthies M, Klasmeier J (2008) Chemosphere 70:753
EMEA CHMP (2006) Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use.
EU Comission Regulation EC 281/96
Capleton AC, Courage C, Rumsby P, Holmes P, Stutt E, Boxall ABA, Levy LS (2006) Toxicol Lett 163:213
Kools SAE, Boxall ABA, Moltmann JF, Bryning G, Koschorreck J, Knacker T (2008) Integr Environ Assess Manag 4:399
García Galán MJ, Díaz-Cruz MS, Barceló D (2008) Trac-Trends Anal Chem 28(6):804–819
Boxall ABA, Johnson P, Smith EJ, Sinclair CJ, Stutt E, Levy LS (2006) J Agric Food Chem 54:2288
Jjemba PK (2002) Agric Ecosyst Environ 93:267
Migliore L, Brambilla G, Cozzolino S, Gaudio L (1995) Agric Ecosyst Environ 52:103
Migliore L, Brambilla G, Grassitellis A, Dojmi di Delupis G (1993) Int J Salt Lake Res 2:141
Migliore L, Civitareale C, Brambilla G, Cozzolino S, Casoria P, Gaudio L (1997) Agric Ecosyst Environ 65:163
Forni C, Cascone A, Fiori M, Migliore L (2002) Water Res 36:3398
Dolliver H, Kumar K, Gupta S (2007) J Environ Qual 36:1224
Hou XL, Shen JZ, Zhang SX, Jiang HY, Coats JR (2003) J Agric Food Chem 51:7725
Ramirez AJ, Brain RA, Usenko S, Mottaleb MA, O'Donnell JG, Stahl LL, Wathen JB, Snyder BD, Pitt JL, Perez-Hurtado P, Dobbins LL, Brooks BW, Chambliss CK (2009) Environ Toxicol Chem 28:2587
Hamscher G, Pawelzick HT, Sczesny S, Nau H, Hartung J (2003) Environ Health Perspect 111:1590
Hirsch R, Ternes T, Haberer K, Kratz KL (1999) Sci Total Environ 225:109
García-Galán MJ, Garrido T, Fraile J, Ginebreda A, Díaz-Cruz MS, Barceló D (2011) Anal Bioanal Chem 399:795
Ginebreda A, Muñoz I, de Alda ML, Brix R, López-Doval J, Barceló D (2010) Environ Int 36:153
Ferrari B, Mons R, Vollat B, Fraysse B, Paxéus N, Lo Giudice R, Pollio A, Garric J (2004) Environ Toxicol Chem 23:1344
Grung M, Källqvist T, Sakshaug S, Skurtveit S, Thomas KV (2008) Ecotoxicol Environ Saf 71:328
Park S, Choi K (2008) Ecotoxicology 17:526
Sanderson H, Johnson DJ, Wilson CJ, Brain RA, Solomon KR (2003) Toxicol Lett 144:383
Lutzhoft HHC, Halling-Sorensen B, Jorgensen SE (1999) Arch Environ Contam Toxicol 36:1
Eguchi K, Nagase H, Ozawa M, Endoh YS, Goto K, Hirata K, Miyamoto K, Yoshimura H (2004) Chemosphere 57:1733
EMEA CVMP (2004). Guideline on environmental impact assessment for veterinary medicine products Phase II.
Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Chaudhry MJI, Arshad M, Mahmood S, Ali A, Khan AA (2004) Nature 427:630
Choi KJ, Kim SG, Kim CW, Kim SH (2007) Chemosphere 66(6):977
Al-Ahmad A, Daschner FD, Kümmerer K (1999) Arch Environ Contam Toxicol 37:158
Dokianakis SN, Kornaros ME, Lyberatos G (2004) Water Sci Technol 50:341
Fountoulakis M, Drilla P, Stamatelatou K, Lyberatos G (2004) Water Sci Technol 50(5):335
Brain RA, Ramirez AJ, Fulton BA, Chambliss CK, Brooks BW (2008) Environ Sci Technol 42:8965
Jung J, Kim Y, Kim J, Jeong DH, Choi K (2008) Ecotoxicology 17:37
Baran W, Sochacka J, Wardas W (2006) Chemosphere 65:1295
Gómez-Ramos MDM, Mezcua M, Agüera A, Fernández-Alba AR, Gonzalo S, Rodríguez A, Rosal R (2011) J Hazard Mater 192:18
Yargeau V, Huot JC, Rodayan A, Rouleau L, Roy R, Leask RL (2008) Environ Toxicol 23:492
Acknowledgements
This work has been funded by the Spanish Ministry of Science and Innovation through the projects CEMAGUA (CGL2007-64551/HID) and SCARCE (Consolider Ingenio 2010 CSD2009-00065). MJ García acknowledges AGAUR (Generalitat de Catalunya, Spain) for economic support through an FI predoctoral grant.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg 2011
About this chapter
Cite this chapter
Galán, M.J.G., Díaz-Cruz, M.S., Barceló, D. (2012). Sulfonamide Antibiotics in Natural and Treated Waters: Environmental and Human Health Risks. In: Barceló, D. (eds) Emerging Organic Contaminants and Human Health. The Handbook of Environmental Chemistry(), vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/698_2011_129
Download citation
DOI: https://doi.org/10.1007/698_2011_129
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-28131-0
Online ISBN: 978-3-642-28132-7
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)