Skip to main content

Isopanduratin A Isolated from Boesenbergia pandurata Reduces HepG2 Hepatocellular Carcinoma Cell Proliferation in Both Monolayer and Three-Dimensional Cultures

  • Conference paper
  • First Online:
Cancer Biology and Advances in Treatment

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

3D:

Three-dimensional

B. pandurate :

Boesenbergia pandurata

BPE:

Boesenbergia pandurata extract

FBS:

Fetal bovine serum

P/S:

Penicillin-streptomycin

PA:

Panduratin A

PI:

Propidium Iodide

References

  • Abdelwahab, S. I., et al. (2011). The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action. Journal of Ethnopharmacology, 137(2), 963–970.

    Article  CAS  PubMed  Google Scholar 

  • Cao, X. D., et al. (2012). Antitumor constituents from the leaves of Carya cathayensis. Natural Product Research, 26(22), 2089–2094.

    CAS  PubMed  Google Scholar 

  • Cheah, S. C., et al. (2011). Panduratin A inhibits the growth of A549 cells through induction of apoptosis and inhibition of NF-kappaB translocation. Molecules, 16(3), 2583–2598.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cheah, S. C., et al. (2013). Panduratin A, a possible inhibitor in metastasized A549 cells through inhibition of NF-kappa B translocation and chemoinvasion. Molecules, 18(8), 8764–8778.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cheenpracha, S., et al. (2006). Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata. Bioorganic & Medicinal Chemistry, 14(6), 1710–1714.

    Article  CAS  Google Scholar 

  • Du, J., et al. (2012). Antiproliferative effect of alpinetin in BxPC-3 pancreatic cancer cells. International Journal of Molecular Medicine, 29(4), 607–612.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Heyne, K. (1987). Tumbuhan berguna Indonesia. I. Jakarta: Yayasan Sarana Wana Jaya.

    Google Scholar 

  • Jadaun, A., Subbarao, N., & Dixit, A. (2017). Allosteric inhibition of topoisomerase I by pinostrobin: Molecular docking, spectroscopic and topoisomerase I activity studies. Journal of Photochemistry and Photobiology. B, 167, 299–308.

    Article  CAS  Google Scholar 

  • Jaudan, A., et al. (2018). Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action. PLoS One, 13(2), e0191523.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kim, D. Y., et al. (2012). Boesenbergia pandurata attenuates diet-induced obesity by activating AMP-activated protein kinase and regulating lipid metabolism. International Journal of Molecular Sciences, 13(1), 994–1005.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kim, T., et al. (2016). Standardized Boesenbergia pandurata extract stimulates exercise endurance through increasing mitochondrial biogenesis. Journal of Medicinal Food, 19(7), 692–700.

    Article  CAS  PubMed  Google Scholar 

  • Kim, D. U., et al. (2017). Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double-blind, and placebo-controlled study. Journal of Cosmetic Dermatology, 16(4), 512–519.

    Article  PubMed  Google Scholar 

  • Kim, H., et al. (2018a). Inhibitory effects of Boesenbergia pandurata on age-related periodontal inflammation and alveolar bone loss in Fischer 344 rats. Journal of Microbiology and Biotechnology, 28(3), 357–366.

    Article  CAS  PubMed  Google Scholar 

  • Kim, H., et al. (2018b). Inhibitory effects of standardized Boesenbergia pandurata extract and its active compound Panduratin A on lipopolysaccharide-induced periodontal inflammation and alveolar bone loss in rats. Journal of Medicinal Food, 21(10), 961–970.

    Article  CAS  PubMed  Google Scholar 

  • Kim, H., et al. (2018c). Inhibitory effects of Panduratin A on periodontitis-induced inflammation and osteoclastogenesis through inhibition of MAPK pathways in vitro. Journal of Microbiology and Biotechnology, 28(2), 190–198.

    Article  CAS  PubMed  Google Scholar 

  • Kumar, M. A., et al. (2007). Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells. Molecular Carcinogenesis, 46(3), 231–241.

    Article  CAS  PubMed  Google Scholar 

  • Lai, S. L., et al. (2015). Cytotoxic mechanisms of panduratin A on A375 melanoma cells: A quantitative and temporal proteomics analysis. Proteomics, 15(9), 1608–1621.

    Article  CAS  PubMed  Google Scholar 

  • Lai, S. L., Mustafa, M. R., & Wong, P. F. (2018). Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway. Phytomedicine, 42, 144–151.

    Article  CAS  PubMed  Google Scholar 

  • Liu, Q., et al. (2018). Panduratin A inhibits cell proliferation by inducing G0/G1 phase cell cycle arrest and induces apoptosis in breast cancer cells. Biomolecules & Therapeutics (Seoul), 26(3), 328–334.

    Article  CAS  Google Scholar 

  • Nguyen, N. T., et al. (2017). Constituents of the rhizomes of Boesenbergia pandurata and their antiausterity activities against the PANC-1 Human Pancreatic Cancer Line. Journal of Natural Products, 80(1), 141–148.

    Article  CAS  PubMed  Google Scholar 

  • Pandji, C., et al. (1993). Insecticidal constituents from four species of the Zingiberaceae. Phytochemistry, 34(2), 415–419.

    Article  CAS  Google Scholar 

  • PT, E. (1995). Medicinal herb index in Indonesia (2nd ed.). Jakarta: PT. Eisai Indonesia.

    Google Scholar 

  • Punvittayagul, C., et al. (2011). Effect of pinocembrin isolated from Boesenbergia pandurata on xenobiotic-metabolizing enzymes in rat liver. Drug Metabolism Letters, 5(1), 1–5.

    Article  CAS  PubMed  Google Scholar 

  • Rukayadi, Y., Lee, K., Han, S., Yong, D., & Hwang, J. K. (2009). In vitro activities of panduratin A against clinical Staphylococcus strains. Antimicrobial Agents and Chemotherapy, 53(10), 4529–4532.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rukayadi, Y., et al. (2010). In vitro antibacterial activity of panduratin A against enterococci clinical isolates. Biological & Pharmaceutical Bulletin, 33(9), 1489–1493.

    Article  CAS  Google Scholar 

  • Seniya, C., et al. (2013). Antiviral potential of 4-hydroxypanduratin A, secondary metabolite of Fingerroot, Boesenbergia pandurata (Schult.), towards Japanese Encephalitis virus NS2B/NS3 protease. Bioinformation, 9(1), 54–60.

    Article  PubMed Central  PubMed  Google Scholar 

  • Smolarz, H. D., et al. (2006). Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans. Zeitschrift für Naturforschung. Section C, 61(1–2), 64–68.

    Article  CAS  Google Scholar 

  • Taweechaisupapong, S., et al. (2010). Antimicrobial effects of Boesenbergia pandurata and Piper sarmentosum leaf extracts on planktonic cells and biofilm of oral pathogens. Pakistan Journal of Pharmaceutical Sciences, 23(2), 224–231.

    CAS  PubMed  Google Scholar 

  • Win, N. N., et al. (2007). Bioactive secondary metabolites from Boesenbergia pandurata of Myanmar and their preferential cytotoxicity against human pancreatic cancer PANC-1 cell line in nutrient-deprived medium. Journal of Natural Products, 70(10), 1582–1587.

    Article  CAS  PubMed  Google Scholar 

  • Woo, S. W., et al. (2015). Effect of standardized Boesenbergia pandurata extract and its active compound panduratin a on skin hydration and barrier function in human epidermal keratinocytes. Preventive Nutrition and Food Science, 20(1), 15–21.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wu, L., et al. (2015). Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium. Drug Design, Development and Therapy, 9, 6119–6127.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yanti, R., et al. (2009). Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro. Journal of Oral Science, 51(1), 87–95.

    Article  CAS  PubMed  Google Scholar 

  • Yun, J. M., et al. (2005). Induction of apoptosis by Panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells. Planta Medica, 71(6), 501–507.

    Article  CAS  PubMed  Google Scholar 

  • Yun, J. M., et al. (2006). Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgen-independent human prostate cancer cells PC3 and DU145. Carcinogenesis, 27(7), 1454–1464.

    Article  CAS  PubMed  Google Scholar 

  • Zhao, X., et al. (2018). Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling. Molecular Medicine Reports, 18(4), 4030–4036.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Vietnam National University, Ho Chi Minh City, Vietnam, under grant A2015-18-01.

Conflict of Interest

The authors declare no conflict of interest.

Author’s Contributions

Hai Xuan Nguyen, Mai Thi Thanh Nguyen, and Nhan Trung Nguyen isolated the compounds. Sinh Truong Nguyen, Nghia Minh Do, Duyen Ho-Khanh Tran, Ngoc Bao To, and Phuc Hong Vo performed the experiments. Sinh Truong Nguyen analyzed the results and wrote the manuscript. Kiet Dinh Truong and Phuc Van Pham suggested the idea of the study and generally supervised the study. All authors approved the final version of manuscript.

Author information

Authors and Affiliations

Consortia

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Sinh Truong Nguyen. et al. (2020). Isopanduratin A Isolated from Boesenbergia pandurata Reduces HepG2 Hepatocellular Carcinoma Cell Proliferation in Both Monolayer and Three-Dimensional Cultures. In: Pham, P.V. (eds) Cancer Biology and Advances in Treatment. Advances in Experimental Medicine and Biology(), vol 1292. Springer, Cham. https://doi.org/10.1007/5584_2020_523

Download citation

Publish with us

Policies and ethics