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Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients

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Health and Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((CLEXBI,volume 1279))

Abstract

Selectins and their ligands play an important role in atherosclerosis. The role of these adhesion molecules in the pathogenesis of obstructive sleep apnea (OSA) may be of clinical relevance. Therefore, the aim of this study was to assess the serum content of platelet P-selectin (P-SEL) and P-selectin glycoprotein ligand 1 (PSGL-1) in different OSA stages. The study was performed in nondiabetic patients, aged 32–71, in whom OSA was verified by polysomnography. The apnea/hypopnea index (AHI) was used to stratify OSA stages: AHI <5, no sleep pathology (OSA-0); AHI 5–15, (OSA-1); AHI 16–30, (OSA-2); and AHI >30, (OSA-3). There were 16 patients in each group. P-SEL and PSGL-1 were assessed by ELISA kits. There were no appreciable differences in the patients’ glucose or high-specificity C-reactive protein content. We found that P-SEL and PSGL-1 significantly increased from OSA-0 to OSA-3. There were the following positive associations in all OSA patients: P-SEL vs. AHI, PSGL-1 vs. AHI, and P-SEL vs. PSGL-1. In addition, the adhesion molecules are associated with the anthropometric parameters, oxygen saturation, and sleep architecture in the OSA-1 group. We conclude that the adhesion molecules consistently increase in the blood of nondiabetic OSA patients, along with progression of disorder severity.

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References

  • Blann AD, Nadar SK, Lip GY (2003) The adhesion molecule P-selectin and cardiovascular disease. Eur Heart J 24(24):2166–2179

    Article  CAS  PubMed  Google Scholar 

  • Budhiraja R, Parthasarathy S, Quan SF (2007) Endothelial dysfunction in obstructive sleep apnea. J Clin Sleep Med 3(4):409–415

    Article  PubMed  PubMed Central  Google Scholar 

  • Burger PC, Wagner DD (2003) Platelet P-selectin facilitates atherosclerotic lesion development. Blood 101(7):2661–2666

    Article  CAS  PubMed  Google Scholar 

  • Chiu CA, Wu CJ, Yang CH, Fang CY, Hsieh YK, Hang CL, Hung WC, Chen CJ, Chen SM, Yu TH, Yeh KH, Fu M, Yip HK (2005) Levels and value of soluble P-selectin following acute myocardial infarction: evaluating the link between soluble P-selectin levels and recruitment of circulating white blood cells and the marker for the rapid diagnosis of chest pain. Chang Gung Med J 28(10):699–707

    PubMed  Google Scholar 

  • Chung I, Choudhury A, Patel J, Lip GY (2009) Soluble, platelet-bound, and total P-selectin as indices of platelet activation in congestive heart failure. Ann Med 41(1):45–51

    Article  CAS  PubMed  Google Scholar 

  • Cofta S, Wysocka E, Dziegielewska-Gesiak S, Michalak S, Piorunek T, Batura-Gabryel H, Torlinski L (2013) Plasma selectins in patients with obstructive sleep apnea. Adv Exp Med Biol 756:113–119

    Article  CAS  PubMed  Google Scholar 

  • Dyugovskaya L, Polyakov A, Lavie P, Lavie L (2008) Delayed neutrophil apoptosis in patients with sleep apnea. Am J Respir Crit Care Med 177(5):544–554

    Article  CAS  PubMed  Google Scholar 

  • Frenette PS, Denis CV, Weiss L, Jurk K, Subbarao S, Kehrel B, Hartwig JH, Vestweber D, Wagner DD (2000) P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med 191(8):1413–1422

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gimbrone MA Jr, Garcia-Cardena G (2016) Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res 118(4):620–636

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guo L, Sun G, Wang G, Ning W, Zhao K (2015) Soluble P-selectin promotes acute myocardial infarction onset but not severity. Mol Med Rep 11(3):2027–2033

    Article  CAS  PubMed  Google Scholar 

  • Hansson GK (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352(16):1685–1695

    Article  CAS  PubMed  Google Scholar 

  • Horváth P, Lázár Z, Mészáros M, Gálffy G, Puskás R, Losonczy G, Kunos L, Bikov A (2018) The role of P- selectin glycoprotein ligand-1 (PSGL-1) in the pathogenesis of obstructive sleep apnea. Eur Respir J 52(Suppl 62):PA2536

    Google Scholar 

  • Huo Y, Xia L (2009) P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall. Trends Cardiovasc Med 19(4):140–145

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ikeda H, Nakayama H, Oda T, Kuwano K, Muraishi A, Sugi K, Koga Y, Toshima H (1994) Soluble form of P-selectin in patients with acute myocardial infarction. Coron Artery Dis 5(6):515–518

    CAS  PubMed  Google Scholar 

  • Johnson-Tidey RR, McGregor JL, Taylor PR, Poston RN (1994) Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. Am J Pathol 144(5):952–961

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jurado-Gamez B, Bujalance Cabrera C, Caballero Ballesteros L, Marin Hinojosa C, Munoz Cabrera L, Perez-Jimenez F, Lopez-Miranda J (2012) Association of cellular adhesion molecules and oxidative stress with endothelial function in obstructive sleep apnea. Intern Med 51(4):363–368

    Article  PubMed  Google Scholar 

  • Kappelmayer J, Nagy B Jr (2017) The interaction of selectins and PSGL-1 as a key component in thrombus formation and cancer progression. Biomed Res Int 2017:6138145

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, Harrod CG (2017) Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 13(3):479–504

    Article  PubMed  PubMed Central  Google Scholar 

  • Kitamura K, Sato K, Sawabe M, Yoshida M, Hagiwara N (2018) P-selectin glycoprotein ligand-1 (PSGL-1) expressing CD4 T cells contribute plaque instability in acute coronary syndrome. Circ J 82(8):2128–2135

    Article  CAS  PubMed  Google Scholar 

  • Laratta CR, Ayas NT, Povitz M, Pendharkar SR (2017) Diagnosis and treatment of obstructive sleep apnea in adults. CMAJ 189(48):E1481–E1488

    Article  PubMed  PubMed Central  Google Scholar 

  • Lavie P, Herer P, Peled R, Berger I, Yoffe N, Zomer J, Rubin AH (1995) Mortality in sleep apnea patients: a multivariate analysis of risk factors. Sleep 18(3):149–157

    Article  CAS  PubMed  Google Scholar 

  • Ley K (2003) The role of selectins in inflammation and disease. Trends Mol Med 9(6):263–268

    Article  CAS  PubMed  Google Scholar 

  • Li B, Lu X, Wang J, He X, Gu Q, Wang L, Yang Y (2018) The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR(−/−) mice. Int J Biol Sci 14(1):36–46

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lui MM, Sau-Man M (2012) OSA and atherosclerosis. J Thorac Dis 4(2):164–172

    PubMed  PubMed Central  Google Scholar 

  • Luo W, Wang H, Ohman MK, Guo C, Shi K, Wang J, Eitzman DT (2012) P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis 220(1):110–117

    Article  CAS  PubMed  Google Scholar 

  • Lusis AJ (2000) Atherosclerosis. Nature 407(6801):233–241

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McEver RP (2001) Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost 86(3):746–756

    CAS  PubMed  Google Scholar 

  • McNicholas WT, Bonsigore MR (2007) Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J 29(1):156–178

    Article  CAS  PubMed  Google Scholar 

  • Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Oda N, Tanaka A, Yamamoto M, Ohta S, O'Donnell CP, Adachi M (2007) Silent brain infarction and platelet activation in obstructive sleep apnea. Am J Respir Crit Care Med 175(6):612–617

    Article  PubMed  Google Scholar 

  • Nacher M, Serrano-Mollar A, Farre R, Panes J, Segui J, Montserrat JM (2007) Recurrent obstructive apneas trigger early systemic inflammation in a rat model of sleep apnea. Respir Physiol Neurobiol 155(1):93–96

    Article  PubMed  Google Scholar 

  • O’Connor CM, Gurbel PA, Serebruany VL (1999) Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure. Am J Cardiol 83(9):1345–1349

    Article  PubMed  Google Scholar 

  • Ozaki Y, Imanishi T, Teraguchi I, Nishiguchi T, Orii M, Shiono Y, Shimamura K, Ishibashi K, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Kubo T, Akasaka T (2014) Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography. Atherosclerosis 233(2):697–703

    Article  CAS  PubMed  Google Scholar 

  • Priou P, Gagnadoux F, Tesse A, Mastronardi ML, Agouni A, Meslier N, Racineux JL, Martinez MC, Trzepizur W, Andriantsitohaina R (2010) Endothelial dysfunction and circulating microparticles from patients with obstructive sleep apnea. Am J Pathol 177(2):974–983

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O'Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, Ali T, Lebowitz M, Punjabi NM (2010) Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med 182(2):269–277

    Article  PubMed  PubMed Central  Google Scholar 

  • Robinson GV, Pepperell JC, Segal HC, Davies RJ, Stradling JR (2004) Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials. Thorax 59(9):777–782

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanada H, Midorikawa S, Yatabe J, Yatabe MS, Katoh T, Baba T, Hashimoto S, Watanabe T (2005) Elevation of serum soluble E- and P-selectin in patients with hypertension is reversed by benidipine, a long-acting calcium channel blocker. Hypertens Res 28(11):871–878

    Article  CAS  PubMed  Google Scholar 

  • Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, Hamilton GS, Dharmage SC (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81

    Article  PubMed  Google Scholar 

  • Sharma S, Culebras A (2016) Sleep apnoea and stroke. Stroke Vasc Neurol 1(4):185–191

    Article  PubMed  PubMed Central  Google Scholar 

  • Verhaar MC, Beutler JJ, Gaillard CA, Koomans HA, Fijnheer R, Rabelink TJ (1998) Progressive vascular damage in hypertension is associated with increased levels of circulating P-selectin. J Hypertens 16(1):45–50

    Article  CAS  PubMed  Google Scholar 

  • Wang Q, Zhao W, Bai S (2013) Association between plasma soluble P-selectin elements and progressive ischemic stroke. Exp Ther Med 5(5):1427–1433

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V (2005) Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353(19):2034–2041

    Article  CAS  PubMed  Google Scholar 

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Conflict of Interest

The authors declare no conflicts of interests in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of Poznan University of Medical Sciences in Poland.

Informed Consent

Written informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland

    H. M. Winiarska, S. Cofta & T. Piorunek

  2. Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland

    L. Bielawska, A. Płóciniczak & E. Wysocka

Authors
  1. H. M. Winiarska
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  2. S. Cofta
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  3. L. Bielawska
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  4. A. Płóciniczak
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  5. T. Piorunek
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  6. E. Wysocka
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Corresponding author

Correspondence to S. Cofta .

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Editors and Affiliations

  1. Opole Medical School, Warsaw, Poland

    Mieczyslaw Pokorski

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Winiarska, H.M., Cofta, S., Bielawska, L., Płóciniczak, A., Piorunek, T., Wysocka, E. (2020). Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients. In: Pokorski, M. (eds) Health and Medicine. Advances in Experimental Medicine and Biology(), vol 1279. Springer, Cham. https://doi.org/10.1007/5584_2020_501

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