Abstract
This study investigated hemodynamic characteristics of obstructive sleep apnea (OSA) accompanied by hypertensive disease in obese men, in whom blood pressure was pharmacologically controlled within the normal range, not exceeding 140/90 mmHg. There were 21 severe OSA patients (mean age 54.1 ± 9.3 years, apnea-hypopnea index of 47.1 ± 18.8 episodes per hour) included in the study, in whom OSA was diagnosed with polysomnography. The control group consisted of healthy normotensive age-matched subjects. Hemodynamic profile was recorded nonivasively with impedance cardiography. Brachial blood pressure and radial artery tonometry were performed to capture and reconstruct peripheral radial and central aortic pressure waveforms in both groups of subjects. Compared to healthy men, OSA patients had a significantly higher body mass index (BMI); the mean increase in BMI amounted to 6.4 ± 1.2 kg/m2. The patients also presented significant differences in the hemodynamic profile. The difference consisted of a faster heart rate, higher peripheral pulse pressure, and reduced blood flow acceleration and velocity indices, describing myocardial contractility. Notably, the significance of hemodynamic differences in OSA patients disappeared in the analysis adjusted for the outstanding increase in BMI. In conclusion, the findings strongly suggest that obesity rather than the hypertensive disease per se is a source of hemodynamic consequences in OSA patients.
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Acknowledgments
The authors would like to thank all the participants involved in this study. MK and MG have equal contributions to this article.
Conflicts of Interest
The authors declare no conflicts of interest in relation to this article.
Ethical Approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Poznan University of Medical Sciences (approval no. 278/14).
Informed Consent
Written informed consent was obtained from all individual participants included in the study.
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Kostrzewska, M. et al. (2020). Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension. In: Pokorski, M. (eds) Medical Research and Development. Advances in Experimental Medicine and Biology(), vol 1271. Springer, Cham. https://doi.org/10.1007/5584_2020_478
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DOI: https://doi.org/10.1007/5584_2020_478
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