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Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis

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Pertussis Infection and Vaccines

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 1183))

Abstract

Bordetella pertussis produces several toxins that affect host-pathogen interactions. Of these, the major toxins that contribute to pertussis infection and disease are pertussis toxin, adenylate cyclase toxin-hemolysin and tracheal cytotoxin. Pertussis toxin is a multi-subunit protein toxin that inhibits host G protein-coupled receptor signaling, causing a wide array of effects on the host. Adenylate cyclase toxin-hemolysin is a single polypeptide, containing an adenylate cyclase enzymatic domain coupled to a hemolysin domain, that primarily targets phagocytic cells to inhibit their antibacterial activities. Tracheal cytotoxin is a fragment of peptidoglycan released by B. pertussis that elicits damaging inflammatory responses in host cells. This chapter describes these three virulence factors of B. pertussis, summarizing background information and focusing on the role of each toxin in infection and disease pathogenesis, as well as their role in pertussis vaccination.

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  1. Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA

    Karen Scanlon, Ciaran Skerry & Nicholas Carbonetti

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  1. Vaccine Preventable Diseases - Reference Labs Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy

    Giorgio Fedele

  2. Former Research Director in the Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy

    Clara Maria Ausiello

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Scanlon, K., Skerry, C., Carbonetti, N. (2019). Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis. In: Fedele, G., Ausiello, C. (eds) Pertussis Infection and Vaccines. Advances in Experimental Medicine and Biology(), vol 1183. Springer, Cham. https://doi.org/10.1007/5584_2019_403

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