Skip to main content
SpringerLink
Log in
Book cover

Cell Biology and Translational Medicine, Volume 5 pp 101–121Cite as

Stem Cells for the Oromaxillofacial Area: Could they be a promising source for regeneration in dentistry?

  • Chapter
  • First Online:

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1144))

Abstract

Oromaxillofacial tissues (OMT) are composed of tooth and bone, together with nerves and blood vessels. Such a composite material is a huge source for mesenchymal stem cells (MSCs) that can be obtained with ease from extracted teeth, teeth structures and socket blood, flapped gingiva tissue, and mandibular/maxillar bone marrow. They offer a biological answer for restoring damaged dental tissues such as the regeneration of alveolar bone, prevention of pulp tissue defects, and dental structures. Dental tissue-derived mesenchymal stem cells share properties with bone marrow-derived mesenchymal stem cells and there is a considerable potential for these cells to be used in different stem cell-based therapies, such as bone and nerve regeneration. Dental pulp tissue might be a very good source for neurological disorders whereas gingiva-derived mesenchymal stem cells could be a good immune modulatory/suppressive mediators. OMT-MSCs is also promising candidates for regeneration of orofacial tissues from the perspective of developmental fate. Here, we review the fundamental biology and potential for future regeneration strategies of MSCs in oromaxillofacial research.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

DP-MSCs:

Dental pulp mesenchymal stem cells

iBM-MSCs:

iliac bone marrow mesenchymal stem cells

MSCs:

Mesenchymal stem cells

OMT:

Oromaxillofacial stem cell

OMT-SCs:

Oromaxillofacial stem cells

PDL-MSCs:

Periodontal ligament mesenchymal stem cells

SHED:

Exfoliated deciduous teeth mesenchymal stem cells

References

  • Abedini S, Kaku M, Kawata T, Koseki H, Kojima S, Sumi H, Motokawa M, Fujita T, Ohtani J, Ohwada N, Tanne K (2011) Effects of cryopreservation with a newly-developed magnetic field programmed freezer on periodontal ligament cells and pulp tissues. Cryobiology 62:181–187

    Article  CAS  PubMed  Google Scholar 

  • Aghajani F, Hooshmand T, Khanmohammadi M, Khanjani S, Edalatkhah H, Zarnani A-H, Kazemnejad S (2016) Comparative immunophenotypic characteristics, proliferative features, and osteogenic differentiation of stem cells isolated from human permanent and deciduous teeth with bone marrow. Mol Biotechnol 58(6):415–427. https://doi.org/10.1007/s12033-016-9941-2

    Article  CAS  PubMed  Google Scholar 

  • Ajlan SA, Ashri NY, Aldahmash AM, Alnbaheen MS (2015) Osteogenic differentiation of dental pulp stem cells under the influence of three different materials. BMC Oral Health 2015:15. https://doi.org/10.1186/s12903-015-0113-8

    Article  CAS  Google Scholar 

  • Akintoye SO, Lam T, Shi S, Brahim J, Collins MT, Robey PG (2006) Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals. Bone 38(6):758–768

    Article  CAS  PubMed  Google Scholar 

  • Alraies A, Alaidaroos NYA, Waddington RJ, Moseley R, Sloan AJ (2017) Variation in human dental pulp stem cell ageing profiles reflect contrasting proliferative and regenerative capabilities. BMC Cell Biol 18(1):12. https://doi.org/10.1186/s12860-017-0128-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • An Y, Wei W, Jing H, Ming L, Liu S, Jin Y (2015) Bone marrow mesenchymal stem cell aggregate: an optimal cell therapy for full-layercutaneous wound vascularization and regeneration. Sci Rep 5:17036. https://doi.org/10.1038/srep17036

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Anitua E (1999) Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 14:529–535

    CAS  PubMed  Google Scholar 

  • Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT (2004) Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 91:4–15

    Article  PubMed  Google Scholar 

  • Arora V, Arora P, Munshi AK (2009) Banking stem cells from human exfoliated deciduous teeth (SHED): saving for the future. J Clin Pediatr Dent 33:289–294

    Article  PubMed  Google Scholar 

  • Asadi-Golshan R, Razban V, Mirzaei E, Rahmanian A, Khajeh S, Mostafavi Pou Z, Dehghani F (2018) Sensory and motor behaviour evidences supporting the usefulness of conditioned medium from dental pulp derived stem cells in spinal cord injury in rats. Asian Spine J 12:785–793

    Article  PubMed  PubMed Central  Google Scholar 

  • Ataç MS, Kılınç Y (2014) J- bone graft for the reconstruction of the jaws. J Craniofac Surg 25(4):1468–1469

    Article  PubMed  Google Scholar 

  • Atari M, Caballé-Serrano J, Gil-Recio C, Giner-Delgado C, Martínez-Sarrà E, García-Fernández DA, Barajas M, Hernandez-Alfaro F, Ferres-Padro E, Giner-Tarrida L (2012) The enhancement of osteogenesis through the use of dental pulp pluripotent stem cells in 3D. Bone 50(4):930–941. https://doi.org/10.1016/j.bone.2012.01.005

    Article  CAS  PubMed  Google Scholar 

  • Aurrekoetxea M, Garcia-Gallastegui P, Irastorza I, Luzuriaga J, Uribe-Etxebarria V, Unda F, Ibarretxe G (2015) Dental pulp stem cells as a multifaceted tool for bioengineering and the regeneration of craniomaxillofacial tissues. Front Physiol 6:289–299. https://doi.org/10.3389/fphys.2015.00289

    Article  PubMed  PubMed Central  Google Scholar 

  • Baba S, Yamada Y (2016) Phase I/II trial of autologous bone marrow stem cell transplantation with a three-dimensional woven-fabric scaffold for periodontitis. Stem Cells Int 2016:6205910. https://doi.org/10.1155/2016/6205910

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beitlitum I, Artzi Z, Nemcovsky CE (2010) Clinical evaluation of particulate allogeneic with and without autogenous bone grafts and resorbable collagen membranes for bone augmentation of atrophic alveolar ridges. Clin Oral Implants Res 21(11):1242–1250

    Article  PubMed  Google Scholar 

  • Berglundh T, Lindhe J (1997) Healing around implants placed in bone defects treated with Bio-Oss. An experimental study in the dog. Clin Oral Implants Res 8:117–124

    Article  CAS  PubMed  Google Scholar 

  • Bhuptani RS, Patravale VB (2016) Porous microscaffolds for 3D culture of dental pulp mesenchymal stem cells. Int J Pharm 515(1–2):555–564. https://doi.org/10.1016/j.ijpharm.2016.10.040

    Article  CAS  PubMed  Google Scholar 

  • Bianco P (2011) Bone and the hematopoietic niche: a tale of two stem cells. Blood 117:5281–5288

    Article  CAS  PubMed  Google Scholar 

  • Bonnamain V, Thinard R, Sergent-Tanguy S, Huet P, Bienvenu G, Naveilhan P, Farges JC, Alliot-Licht B (2013) Human dental pulp stem cells cultured in serum-free supplemented medium. Front Physiol 4:357. https://doi.org/10.3389/fphys.2013.00357

    Article  PubMed  PubMed Central  Google Scholar 

  • Boronat A, Carrillo C, Penarrocha M, Pennarocha M (2010) Dental implants placed simultaneously with bone grafts in horizontal defects: a clinical retrospective study with 37 patients. Int J Oral Maxillofac Implants 25:189–196

    PubMed  Google Scholar 

  • Bouquot JE, Gorlin RJ (1986) Leukoplakia, lichen planus, and other oral keratoses in 23,616 white Americans over the age of 35 years. Oral Surg Oral Med Oral Pathol 61:373–381

    Article  CAS  PubMed  Google Scholar 

  • Bressan E, Ferroni L, Gardin C, Pinton P, Stellini E, Botticelli D, Sivolella S, Zavan B (2012) Donor age-related biological properties of human dental pulp stem cells change in nanostructured scaffolds. PLoS One 7(11):e49146. https://doi.org/10.1371/journal.pone.0049146

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brindley DA, Davie NL, Culme-Seymour EJ, Mason C, Smith DW, Rowley JA (2012) Peak serum: implications of serum supply for cell therapy manufacturing. Regen Med 7:7–13

    Article  PubMed  Google Scholar 

  • Carinci F, Piattelli A, Guida L, Perrotti V, Laino G, Oliva A, Annunziata M, Palmieri A, Pezzetti F (2006) Effects of Emdogain on osteoblast gene expression. Oral Dis 12(3):329–342

    Article  CAS  PubMed  Google Scholar 

  • Caton J, Bostanci N, Remboutsika E, De Bari C, Mitsiadis TA (2011) Future dentistry: cell therapy meets tooth and periodontal repair and regeneration. J Cell Mol Med 15(5):1054–1065. https://doi.org/10.1111/j.1582-4934.2010.01251.x

    Article  PubMed  PubMed Central  Google Scholar 

  • Cha Y, Jeon M, Lee H-S, Kim S, Kim S-O, Lee J-H, Song JS (2015) Effects of in vitro osteogenic induction on in vivo tissue regeneration by dental pulp and periodontal ligament stem cells. J Endod 41:1462–1468

    Article  PubMed  Google Scholar 

  • Chang CC, Chang KC, Tsai SJ, Chang HH, Lin CP (2014) Neurogenic differentiation of dental pulp stem cells to neuron-like cells in dopaminergic and motor neuronal inductive media. J Formos Med Assoc 113:956–965

    Article  CAS  PubMed  Google Scholar 

  • Chen YW, Scutaru TT, Ghetu N, Carasevici E, Lupascu CD, Ferariu D, Pieptu D, Coman CG, Danciu M (2017) The effects of adipose-derived stem cell-differentiated adipocytes on skin burn wound healing in rats. J Burn Care Res 38(1):1–10. https://doi.org/10.1097/BCR.0000000000000466

    Article  PubMed  Google Scholar 

  • D’Aquino R, De Rosa A, Laino G, Caruso F, Guida L, Rullo R, Checchi V, Laino L, Tirino V, Papaccio G (2009) Human dental pulp stem cells: from biology to clinical applications. J Exp Zool B Mol Dev Evol 312(5):408–415. https://doi.org/10.1002/jez.b.21263

    Article  CAS  Google Scholar 

  • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Kreating A, Prockop DJ, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8(4):315–317. https://doi.org/10.1080/14653240600855905

  • Ducret M, Fabre H, Degoul O, Atzeni G, McGuckin C, Forraz N, Alliot-Licht B, Mallein-Gerin F, Perrier-Groult E, Farges JC (2015) Manufacturing of dental pulp cell-based products from human third molars: current strategies and future investigations. Front Physiol 6(213). https://doi.org/10.3389/fphys.2015.00213

  • Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K (2012) Stem cells in dentistry—part I: stem cell sources. J Prosthodont Res 56:151–565

    Article  PubMed  Google Scholar 

  • Eleuterio E, Trubiani O, Sulpizio M, Di Giuseppe F, Pierdomenico L, Marchisio M, Giancola R, Giammaria G, Miscia S, Caputi S, Di Ilio C, Angelucci S (2013) Proteome of human stem cells from periodontal ligament and dental pulp. PLoS One 8(8):e71101. https://doi.org/10.1371/journal.pone.0071101

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferro F, Spelat R, Beltrami AP, Cesselli D, Curcio F (2012) Isolation and characterization of human dental pulp derived stem cells by using media containing low human serum percentage as clinical grade substitutes for bovine serum. PLoS One 7(11):e48945. https://doi.org/10.1371/journal.pone.0048945

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fukumoto T, Sperling JW, Sanyal A, Fitzsimmons JS, Reinholz GG, Conover CA, O’Driscoll SW (2003) Combined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitro. Osteoarthr Cartil 11(1):55–64. https://doi.org/10.1053/joca.2002.0869

    Article  CAS  Google Scholar 

  • Ghieh F, Jurjus R, Ibrahim A, Geagea AG, Daouk H, El Baba B, Chams S, Matar M, Zein W, Iurius A (2015) The use of stem cells in burn wound healing: a review. Biomed Res Int. https://doi.org/10.1155/2015/684084

  • Gomez JA, Gerales Monteiro B, Melo GB, Smith RL, Cavenaghi Pereira da Silva M, Lizier NF, Kerkis A, Cerruti H, Kerkis I (2010) Corneal reconstruction with tisue engineered cell sheets composed of human immature dental pulp stem cells. Invest Ophtalmol Vis Sci 51:1408–1414

    Article  Google Scholar 

  • Gonzalez-King J, Garcia NA, Ontoria Oviedo I, Ciria M, Montero JA, Sepulveda P (2017) Hypoxia inducible factor-1α potentiates jagged 1-mediated angiogenesis by mesenchymal stem cell-derived exosomes. Stem Cells 35:1747–1759

    Article  CAS  PubMed  Google Scholar 

  • Goto N, Fujimoto K, Fujii S, Ida-Yonemochi H, Ohshima H, Kawamoto T, Noshiro M, Shukunami C, Kozai K, Kato Y (2016) Role of MSX1 in osteogenic differentiation of human dental pulp stem cells. Stem Cells Int. https://doi.org/10.1155/2016/8035759

  • Gronthos S, Brahim J, Li W, Fisher L, Cherman N, Boyde A, Denbesten P, Robey PG, Shi S (2002) Stem cell properties of human dental pulp stem cells. J Dent Res 81(8):531–535

    Article  CAS  PubMed  Google Scholar 

  • Gronthos S, Mankani M, Brahim J, Gehron Robey P, Shi S (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci 97(25):13625–13630

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grottkau BE, Purudappa PP, Lin Y (2010) Multilineage differentiation of dental pulp stem cells from green fluorescent protein transgenic mice. Int J Oral Sci 2:21–27

    Article  PubMed  PubMed Central  Google Scholar 

  • Guilak F, Lott KE, Awad HA, Cao Q, Hicok KC, Fermor B, Gimble JM (2006) Clonal analysis of the differentiation potential of human adiposederived adult stem cells. J Cell Physiol 206:229–237

    Article  CAS  PubMed  Google Scholar 

  • Hämmerle CH, Jung RE, Yaman D, Lang NP (2008) Ridge augmentation by applying bioresorbable membranes and deproteinized bovine bone mineral: A report of twelve consecutive cases. Clin Oral Implants Res 19:19–25

    PubMed  Google Scholar 

  • Hargreaves KM, Berman LH, Rotstein I (2016) Cohen’s pathways of the pulp, 11th edn. Elsevier, St. Louis

    Google Scholar 

  • Hassani A, Khojasteh A, Shamsabad AN (2005) The anterior palate as a donor site in maxillofacial bone grafting: a quantitative anatomic study. J Oral Maxillofac Surg 63:1196–1200

    Article  PubMed  Google Scholar 

  • Hayashi Y, Murakami M, Kawamura R, Ishizaka R, Fukuta O, Nakashima M (2015) CXCL14 and MCP1 are potent trophic factors associated with cell migration and angiogenesis leading to higher regenerative potential of dental pulp side population cells. Stem Cell Res Ther 6:111. https://doi.org/10.1186/s13287-015-0088-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Herberts CA, Kwa MS, Hermsen HP (2011) Risk factors in the development of stem cell therapy. J Transl Med 9:29–42

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang GT, Gronthos S, Shi S (2009) Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J Dent Res 88:792–806

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ishkitiev N, Yaegaki K, Imai T, Tanaka T, Fushimi N, Mitev V, Okada M, Tominaga N, Ono S, Ishikawa H (2015) Novel management of acute or secondary biliary liver conditions using hepatically differentiated human dental pulp cells. Tissue Eng Part A 21:586–593

    Article  CAS  PubMed  Google Scholar 

  • Ismail SB, Kumar SK, Zain RB (2007) Oral lichen planus and lichenoid reactions; Etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci 49:89–106

    Article  PubMed  Google Scholar 

  • Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y (2015) Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function. BMJ Open Diabetes Res Care 19:3(1):e000128. https://doi.org/10.1136/bmjdrc-2015-000128

    Article  Google Scholar 

  • Jang J-H, Lee H-W, Cho KM, Shin H-W, Kang MK, Park SH, Kim E (2016) In vitro characterization of human dental pulp stem cells isolated by three different methods. Restor Dent Endod 41(4):283–295

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaku M, Kamada H, Kawata T, Koseki H, Abedini S, Kojima S, Motokawa M, Fujita T, Ohtani J, Tsuka N, Matsuda Y, Sunagawa H, Hernandes RA, Ohwada N, Tanne K (2010) Cryopreservation of periodontal ligament cells with magnetic field for tooth banking. Cryobiology 61(1):73–78

    Article  CAS  PubMed  Google Scholar 

  • Kang C-M, Kim H, Song JS, Choi B-J, Kim S-O, Jung H-S, Moon SJ, Choi HJ (2016) Genetic comparison of stemness of human umbilical cord and dental pulp. Stem Cells Int 2016:1–12

    CAS  Google Scholar 

  • Keating A (2012) Mesenchymal stromal cells: new directions. Cell Stem Cell 10:709–716

    Article  CAS  PubMed  Google Scholar 

  • Kellner M, Steindorff MM, Strempel JF, Winkel A, Kühnel MP, Stiesch M (2014) Differences of isolated dental stem cells dependent on donor age and consequences for autologous tooth replacement. Arch Oral Biol 59:559–567

    Article  PubMed  Google Scholar 

  • Khojasteh A, Behnia H, Shayesteh YS, Morad G, Alikhasi M (2012) Localized bone augmentation with cortical bone blocks tented over different particulate bone substitutes: a retrospective study. Int J Oral Maxillofac Implants 27(6):1481–1493

    PubMed  Google Scholar 

  • Khojasteh A, Morad G, Behnia H (2013) Clinical importance of recipient site characteristics for vertical ridge augmentation: a systematic review of literature and proposal of a classification. J Oral Implantol 39:386–398

    Article  PubMed  Google Scholar 

  • Kim B-C, Bae H, Kwon I-K, Lee E-J, Park J-H, Khademhosseini A, Hwang YS (2012) Osteoblastic/cementoblastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine. Tissue Eng Part B Rev 18(3):235–244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kolerman R, Nissan J, Tal H (2014) Combined osteotome-induced ridge expansion and guided bone regeneration simultaneous with implant placement: a biometric study. Clin Implant Dent Relat Res 16:691–704

    Article  PubMed  Google Scholar 

  • Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E (2016) Mesenchymal stem cells derived from dental pulp: a review. Stem Cells Int 2016:1–12. https://doi.org/10.1155/2016/4709572

    Article  CAS  Google Scholar 

  • Liu J, Yu F, Sun Y, Jiang B, Zhang W, Yang J, Xu GT, Liang A, Liu S (2015) Concise reviews: characteristics and potential applications of human dental tissue-derived mesenchymal stem cells. Stem Cells 33(3):627–638. https://doi.org/10.1002/stem.1909

    Article  CAS  PubMed  Google Scholar 

  • Manimaran K, Sharma R, Sankaranarayanan S, Perumal SM (2016) Regeneration of mandibular ameloblastıma defect with the help of autologous dental pulp stem cells and bucval pad of fat stromal vascular fraction. Ann MAxillofac Surg 6:97–100

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mao JJ, Prockop DJ (2012) Stem cells in the face: tooth regeneration and beyond. Cell Stem Cell 11:291–301. https://doi.org/10.1016/j.stem.2012.08.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mazur P (1984) Freezing of living cells: mechanisms and implications. Am J Phys 247:125–142

    Article  Google Scholar 

  • Mead B, Hill LJ, Blanch RJ, Ward K, Logan A, Berry M, Leadbeater W, Scheven BA (2015) Mesenchymal stromal cell mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma. Cytother. https://doi.org/10.1016/j.jcyt.2015.12.002

  • Mead B, Logan A, Berry M, Leadbeater W, Scheven BA (2013) Intravitreally transplanted dental pulp stem cells promote neuroprotection and axon regeneration of retinal ganglion cells after optic nerve injury. Invest Phtalmol Vis Sci 15:7544–7556

    Article  CAS  Google Scholar 

  • Mead B, Logan A, Berry M, Leadbeater W, Scheven BA (2014) Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cells. PLoS One 9:e109305

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meijndert L, Raghoebar GM, Schüpbach P, Meijer HJ, Vissink A (2005) Bone quality at the implant site after reconstruction of a local defect of the maxillary anterior ridge with chin bone or deproteinised cancellous bovine bone. Int J Oral Maxillofac Surg 34:877–884

    Article  CAS  PubMed  Google Scholar 

  • Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma’ayan A, Enikolopov GN, Frenette PS (2010) Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466:829–834

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mendi A, Gökcınar Yağcı B, Kızıloğlu M, Saraç N, Uğur A, Yılmaz D, Uçkan D (2017) The effects of Syzygium aromaticum, Cinnamomum zeylanicum, and Salvia triloba extracts on proliferation and differentiation of dental pulp stem cells. J Appl Oral Sci 25(5):515–522

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mendi A, Gökçinar Yagci B, Sarac N, Kiziloglu M, Ugur A, Uçkan D, Yilmaz D (2018) Niche differs the effects of Hypericum perforatum L. on the dental pulp- and bone marrow-derived mesenchymal stem cells proliferation, osteogenic differentiation, and inflammatory response. Cells Tissues Organs 205:208–216. https://doi.org/10.1159/000491633

    Article  CAS  PubMed  Google Scholar 

  • Merkx MA, Maltha JC, Freihofer HP, Kuijpers-Jagtman AM (1999) Incorporation of particulated bone implants in the facial skeleton. Biomaterials 20:2029–2035

    Article  CAS  PubMed  Google Scholar 

  • Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A (2015) Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease. Behav Brain Res 293:189–197. https://doi.org/10.1016/j.bbr.2015.07.043

    Article  CAS  PubMed  Google Scholar 

  • Mitsiadis TA, Orsini G, Jimenez-Rojo L (2015) Stem cell-based approaches in dentistry. Europ Cells Mat 30:248–257. https://doi.org/10.22203/eCM.v030a17

    Article  CAS  Google Scholar 

  • Mitsiadis TA, Woloszyk A, Jimenez-Rojo L (2012) Nanodentistry: combining nanostructured materials and stem cells for dental tissue regeneration. Nanomed 7:1743–1753. https://doi.org/10.2217/nnm.12.146

    Article  CAS  Google Scholar 

  • Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S (2003) SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A 100(10):5807–5812

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mjor IA (2001) Pulp-dentin biology in restorative dentistry. Part 5: clinical management and tissue changes associated with wear and trauma. Quintessence Int 32(10):771–788

    CAS  PubMed  Google Scholar 

  • Morad G, Khojasteh A (2013) Cortical tenting technique versus onlay layered technique for vertical augmentation of atrophic posterior mandibles: a split-mouth pilot study. Implant Dent 22:566–571

    Article  PubMed  Google Scholar 

  • Moshaverinia A, Chen C, Akiyama K, Ansari S, Xu X, Chee WW, Schriker SR, Shi S (2012) Alginate hydrogel as a promising scaffold for dental-derived stem cells: an in vitro study. J Mater Sci Mater Med 23(12):3041–3051. https://doi.org/10.1007/s10856-012-4759-3

    Article  CAS  PubMed  Google Scholar 

  • Moshaverinia A, Chen C, Akiyama K, Xu X, Chee WW, Schricker SR, Shi S (2013) Encapsulated dental-derived mesenchymal stem cells in an injectable and biodegradable scaffold for applications in bone tissue engineering. J Biomed Mater Res A 101(11):3285–3294. https://doi.org/10.1002/jbm.a.34546

    Article  CAS  PubMed  Google Scholar 

  • Moshaverinia A, Chen C, Xu X, Akiyama K, Ansari S, Zadeh HH, Shi S (2014) Bone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffold. Tissue Eng Part A 20(3–4):611–621. https://doi.org/10.1089/ten.TEA.2013.0229

    Article  CAS  PubMed  Google Scholar 

  • Moshtagh PR, Emami SH, Sharifi AM (2013) Differentiation of human adipose-derived mesenchymal stem cell into insulin-producing cells: an in vitro study. J Physiol Biochem 69:451–458

    Article  CAS  PubMed  Google Scholar 

  • Nakajima K, Kunimatsu R, Ando K, Ando T, Hayashi Y, Kihara T, Hiraki T, Tsuka Y, Abe T, Kaku M, Nikawa H, Takata T, Tanne K, Tanimoto K (2018) Comparison of the bone regeneration ability between stem cells from hıman exfoliated deciduous teeth, human dental pulp stem cells and human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 11(497):876–882

    Article  CAS  Google Scholar 

  • Nam H, Kim GH, Bae YK, Jeong DE, Joo KM, Lee K, Lee SH (2017) Angiogenic capacity of dental pulp stem cell regulated by SDF-1α-CXCR4 Axis. Stem Cells Int. https://doi.org/10.1155/2017/8085462

  • Nemeth CL, Janebodin K, Yuan AE, Dennis JE, Reyes M, Kim D-H (2014) Enhanced chondrogenic differentiation of dental pulp stem cells using nanopatterned PEG-GelMA-HA hydrogels. Tissue Eng Part A 20:2817–2829

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nicola F, Marques MR, Odorcyk F, Petenuzzo L, Aristimunha D, Vizuete A, Sanches EF, Pereira DP, Maurmann N, Goncalves CA, Pranke P, Netto CA (2018) Mol Neurobiol. https://doi.org/10.1007/s12035-018-1127-4

  • Niehage C, Karbanová J, Steenblock C, Corbeil D, Hoflack B (2016) Cell surface proteome of dental pulp stem cells identified by label-free mass spectrometry. PLoS One 11(8):e0159824. https://doi.org/10.1371/journal.pone.0159824

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nito C, Sowa K, Nakajima M, Skamoto Y, Nishiyama Y, Nakamura Takkashi A, Nitahara Kasahara Y, Ueda M, Okada T, Kimura K (2018) Transplantation of human dental pulp stem cells ameliorates brain damage following acute cerebral ischemia. Biomed Pharmacother 108:1005–1014

    Article  CAS  PubMed  Google Scholar 

  • Nuti N, Corallo C, Chan BM, Ferrari M, Gerami-Naini B (2016) Multipotent differentiation of human dental pulp stem cells: a literature review. Stem Cell Rev 12:511–523

    Article  CAS  Google Scholar 

  • Oh YH, Che ZM, Hong JC, Lee EJ, Lee SJ, Kim J (2005) Cryopreservation of human teeth for future organization of a tooth bank – a preliminary study. Cryobiology 51:322–329

    Article  CAS  PubMed  Google Scholar 

  • Ozaki W, Buchman SR (1998) Volume maintenance of onlay bone grafts in the craniofacial skeleton: micro-architecture versus embryologic origin. Plast Reconstr Surg 102:291–299

    Article  CAS  PubMed  Google Scholar 

  • Pagella P, Neto E, Lamghari M, Mitsiadis TA (2015) Investigation of orofacial stem cell niches and their innervation through microfluidic devices. Europ Cells Mat 29:213–223

    Article  CAS  Google Scholar 

  • Paino F, La Noce M, Giuliani A, De Rosa A, Mazzoni S, Laino L, Amler E, Papaccio G, Desiderio V, Tirino V (2017) Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering. Clin Sci 25(131):699–713

    Article  CAS  Google Scholar 

  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143–147

    Article  CAS  PubMed  Google Scholar 

  • Polo-Corrales L, Latorre-Esteves M, Ramirez-Vick JE (2014) Scaffold design for bone regeneration. J Nanosci Nanotechnol 14(1):15–56

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Quigley HA (1996) Number of people with glaucoma worldwide. Br J Ophthalmol 80:389–393

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rada C, Jarvis JM, Milstein C (2002) AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization. Proc Natl Acad Sci U S A 99(10):7003–7008. https://doi.org/10.1073/pnas.092160999

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Riccio M, Resca E, Maraldi T, Pisciotta A, Ferrari A, Bruzzesi G, De Pol A (2010) Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures. Eur J Histochem 54(4):46

    Article  CAS  Google Scholar 

  • Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A (2010) Pathogenesis of oral lichen planus-a review. J Oral Pathol Med 39:729–734

    Article  CAS  PubMed  Google Scholar 

  • Sacchetti B, Funari A Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M, Bianco P (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131:324–336

    Article  CAS  PubMed  Google Scholar 

  • Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, Holmstrup P, Porter S, Wray D (1998) Update on oral lichen planus:etiopathogenesis and management. Crit Rev Oral Biol Med 9(1):86–122

    Article  CAS  PubMed  Google Scholar 

  • Seo BM, Miura M, Sonoyama W, Coppe C, Stanyon R, Shi S (2005) Recovery of stem cells from cryopreserved periodontal ligament. J Dent Res 84:907–912

    Article  PubMed  Google Scholar 

  • Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S (2008) SHED repair critical-size calvarial defects in mice. Oral Dis 14(5):428–434

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sequeira-Byron P, Fedorowicz Z, Carter B, Nasser M, Alrowaili EF (2015) Single crowns versus conventional fillings for the restoration of root-filled teeth. Cochrane Database Syst Rev 16(5):CD009109. https://doi.org/10.1002/14651858.cd009109.pub3

    Article  Google Scholar 

  • Shabestari GO, Shayesteh YS, Khojasteh A, Alikhasi M, Moslemi N, Aminian A, Masaeli R, Eslami B, Treister NS (2010) Implant placement in patients with oral bisphosphonate therapy: a case series. Clin Implant Dent Relat Res 12(3):175–180. https://doi.org/10.1111/j.1708-8208.2009.00150.x

    Article  PubMed  Google Scholar 

  • Shayesteh YS, Khojasteh A, Siadat H, Monzavi A, Bassir SH, Hossaini M, Alikhasi A (2013) A comparative study of crestal bone loss and implant stability between osteotome and conventional implant insertion techniques: a randomized controlled clinical trial study. Clin Implant Dent Relat Res 15(3):350–357

    Article  PubMed  Google Scholar 

  • Soares TR, Fidalgo TK, Quirino AS, Ferreira DM, Chianca TK, Risso PA, Maia LC (2016) Is caries a risk factor for dental trauma? A systematic review and meta-analysis. Dent Traumatol 33(1):4–12. https://doi.org/10.1111/edt.12295

    Article  PubMed  Google Scholar 

  • Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT (2008) Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. J Endod 34(2):166–171

    Article  PubMed  PubMed Central  Google Scholar 

  • Suchanek J, Nasry SA, Soukup T (2017) The differentiation potential of human natal dental pulp stem cells into ınsulin producing cells. Folia Biol 63:132–138

    CAS  Google Scholar 

  • Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, Seymour GJ, Bigby M (2002) The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med 13(4):350–365

    Article  CAS  PubMed  Google Scholar 

  • Tatullo M, Falisi G, Amantea M, Rastelli C, Pasuano F, Marrelli M (2015a) Dental pulp stem cells and human periapical cyst mesenchymal St, em cells in bone tissue regeneration: comparison of basal and osteogenic differentiated gene expression of a newly discovered mesenchymal stem cell lineage. J Biol Regul Homeost Agents 29(3):713–718

    CAS  PubMed  Google Scholar 

  • Tatullo M, Marrelli M, Paduano F (2015b) The regenerative medicine in oral and maxillofacial surgery: the most important innovations in the clinical application of mesenchymal stem cells. Int J Med Sci 12(1):72–77. https://doi.org/10.7150/ijms.10706

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Teti G, Salvatore V, Focaroli S, Durante S, Mazzotti A, Dicarlo M, Mattioli-Belmonte M, Orsini G (2015) In vitro osteogenic and odontogenic differentiation of human dental pulp stem cells seeded on carboxymethyl cellulose-hydroxyapatite hybrid hydrogel. Front Physiol 6:297. https://doi.org/10.3389/fphys.2015.00297

    Article  PubMed  PubMed Central  Google Scholar 

  • Tirino V, Paino F, D’Aquino R, Desiderio V, De Rosa A, Papaccio G (2011) Methods for the identification, characterization and banking of human DPSCs: current strategies and perspectives. Stem Cell Rev 7:608–615

    Article  Google Scholar 

  • Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8(9):726–736

    Article  CAS  PubMed  Google Scholar 

  • Ullah I, Park JM, Kang YH, Byun JH, Kim DG, Kim JH, Kang DH, Rho GJ, Park BW (2017) Transplantation of human dental pulp-derived stem cells or differentiated neuronal cells from human dental pulp-derived stem cells identically enhances regeneration of the injured peripheral nerve. Stem Cells Dev 1(26):1247–1257

    Article  CAS  Google Scholar 

  • Urban IA, Nagursky H, Lozada JL, Nagy K (2013) Horizontal ridge augmentation with a collagen membrane and a combination of particulated autogenous bone and anorganic bovine bone-derived mineral: a prospective case series in 25 patients. Int J Periodontics Restorative Dent 33:299–307

    Article  PubMed  Google Scholar 

  • von Arx T, Buser D (2006) Horizontal ridge augmentation using autogenous block grafts and the guided bone regeneration technique with collagen membranes: a clinical study with 42 patients. Clin Oral Implants Res 17:359–366

    Article  Google Scholar 

  • Wang Z, Pan J, Wright JT, Bencharit S, Zhang S, Everett ET, Teixeira FB, Preisser JS (2010) Putative stem cells in human dental pulp with irreversible pulpitis: an exploratory study. J Endod 36(5):820–825. https://doi.org/10.1016/j.joen.2010.02.003. Epub 2010 Mar 19

    Article  PubMed  PubMed Central  Google Scholar 

  • Werle SB, Lindemann D, Steffens D, Demarco FF, de Araujo FB, Pranke P, Casagrande L (2016) Carious deciduous teeth are a potential source for dental pulp stem cells. Clin Oral Investig 20(1):75–81. https://doi.org/10.1007/s00784-015-1477-5

    Article  PubMed  Google Scholar 

  • Xu J, Su Y, Hu L, Caşn A, Gu Y, Liu B, Wu R, Wang S, Wang H (2018) Effect of bone morphogenetic protein 6 on ımmnunomodulatory functions of salivary gland derived mesenchymal stem cells in Sjogren’s syndrome. Stem Cells Dev 15(27):1540–1548

    Article  CAS  Google Scholar 

  • Yamada Y, Ito K, Nakamura S, Ueda M, Nagasaka T (2011) Promising cell based therapy for bone regeneration using stem cekks from deciduous teeth, dental pulp, and bone marrow. Cell Transplant 20:1003–1013

    Article  PubMed  Google Scholar 

  • Yamamoto T, Osako Y, Murakami M, Hayashi Y, Horibe H, Iohara K, Takeuchi N, Okuni N, Hirata H, Nakayama H, Kurita K, Nakashima M (2016) Trophic effects of dental pulp stem cells on Schwann cells in peripheral nerve regeneration. Cell Transplant 25:183–193

    Article  PubMed  Google Scholar 

  • Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T (2015) In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice. Stem Cell Res Ther 6(1):171. https://doi.org/10.1186/s13287-015-0154-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang B, Qiu Y, Zhou N, Ouyang H, Ding J, Cheng B, Sun J (2017) Application of stem cells in oral disease therapy: progresses and perspectives. Front Physiol. https://doi.org/10.3389/fphys.2017.00197

  • Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD (2009) Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis. J Immunol 183(12):7787–7798. https://doi.org/10.4049/jimmunol.0902318

    Article  CAS  PubMed  Google Scholar 

  • Zhang YD, Chen Z, Song YQ, Liu C, Chen YP (2005) Making a tooth: growth factors, transcription factors, and stem cells. Cell Res 15(5):301–316

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgement

The authors thank Prof. Kursad Turksen, the Editor-in-Chief of the Advances in Experimental Medicine and Biology for valuable support to accomplish this work. Icons used in the Figures are freely downloaded from www.flatıcon.com website.

Conflict of Interest

No competing financial interests exist.

Author information

Authors and Affiliations

  1. Faculty of Dentistry, Department of Basic Sciences, Gazi University, Ankara, Turkey

    Ayşegül Mendi

  2. Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Gazi University, Ankara, Turkey

    Hacer Ulutürk, Mustafa Sancar Ataç & Derviş Yılmaz

Authors
  1. Ayşegül Mendi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hacer Ulutürk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mustafa Sancar Ataç
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Derviş Yılmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ayşegül Mendi .

Editor information

Editors and Affiliations

  1. (Retired), Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Mendi, A., Ulutürk, H., Ataç, M.S., Yılmaz, D. (2019). Stem Cells for the Oromaxillofacial Area: Could they be a promising source for regeneration in dentistry?. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 5. Advances in Experimental Medicine and Biology(), vol 1144. Springer, Cham. https://doi.org/10.1007/5584_2018_327

Download citation

Publish with us

Policies and ethics

Search

Navigation