Abstract
The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has raised extreme hope among both scientists and society by means of development of personalized and regenerative medicine. The field of stem cell research has been accelerating with a drastic speed afterwards and many iPSC lines has been produced for understanding the mechanisms of many debilitating diseases which arise in a variety of organ systems. In this review article we try to focus on the current research regarding the use of iPSCs in both disease modeling and regeneration.
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Abbreviations
- CF:
-
Cystic Fibrosis
- CM:
-
Cardiomyocyte
- CRISPR/Cas9:
-
Clustered Regularly Interspaced Palindromic Repeats/Cas9
- FH:
-
Familial Hypercholesterolemia
- hiPSC:
-
Human Induced Pluripotent Stem Cells
- iPSCs:
-
Induced Pluripotent Stem Cells
- LQTS:
-
Long QT Syndrome
- MHC:
-
Major Histocompatibility Complex
- MI:
-
Myocardial Infarction
- WHO:
-
World Health Organization
- ZFN:
-
Zinc Finger Nuclease
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Acknowledgement
Zeynep Tokcaer-Keskin was supported by TUBITAK 114C043, ABAPKO project no 2017/01/12.
Many thanks to Dr. Emre Deniz and Kevser Tokcaer for critical reading. The authors apologize in advance for not including all relevant citations on the subject matter.
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Talug, B., Tokcaer-Keskin, Z. (2018). Induced Pluripotent Stem Cells in Disease Modelling and Regeneration. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 5. Advances in Experimental Medicine and Biology(), vol 1144. Springer, Cham. https://doi.org/10.1007/5584_2018_290
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