Cancer Stem Cells in Metastasis Therapy

Aydemir Çoban, Esra; Şahin, Fikrettin

doi:10.1007/5584_2018_279

Esra Aydemir Çoban⁷ &
Fikrettin Şahin⁷

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1089))

1748 Accesses
10 Citations

Abstract

Tumors consists of subpopulation of cells in which each subtype has contributes to tumor progression. Specifically one subtype known as cancer stem cells are associated with the initiation, progression, resistance to conventional therapies and metastasis. Metastasis is leading cause of cancer related deaths. Overall it is important to consider cancer as a whole in which a mutated cell proliferating indefinitely and forming its hierarchy consisting of subgroups with different molecular signatures. To be able to target this disease we need to evaluate every step including initiation, progression, survival, angiogenesis and finally migration and repopulation. Cancer stem cells do play vital roles in each step however when metastasis can be stopped or eliminated we talk about saving a life or improving its quality. Considering how deeply these cancer stem like cells affect the tumor life and metastasis it is crucial to develop effective strategies against them. Metastatic cascade can also be directed by membrane derived vesicles specifically exosomes. Several studies show the role of exosomes in mediating cellular migration and pre-metastatic niche formation. During this chapter we wanted to explain in detail how the metastasis occur in tumor and how cancer stem cells contribute into the development of metastatic cascade and possibly suggest therapeutic approaches against cancer stem cells.

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Abbreviations

CSCs:: cancer stem cells
MMPs:: matrix metalloproteinases
EMT:: epithelial-to-mesenchymal transition
ALDH1A1:: Aldehyde Dehydrogenase 1 Family Member A1
RTKs:: receptor tyrosine kinases
MICs:: metastasis-initiating cells
TICs:: tumor-initiating cells
hWAPL:: human wings apart-like
HPV:: human papillomavirus
Pdcd4:: programmed cell death protein 4
CXCL12:: chemokine stromal cell-derived factor 1
VEGFR-1:: vascular endothelial growth factor receptor 1
CDs:: cluster of differentiation
CXCR4:: chemokine receptor complex 4
CAFs:: cancer associated fibroblasts
IGF-1:: insuling growth factor 1
IL-17A:: interleukin 17A
DTC:: disseminated tumor cell
MIF:: migration inhibitory factor
RARRES3:: Retinoic Acid Receptor Responder 3
NKX2-1:: homeobox domain-containing transcription
MITF:: microphthalmia-associated transcription factor
EVs:: Extracellular vesicles
ABs:: apoptotic bodies

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Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Istanbul, Turkey
Esra Aydemir Çoban & Fikrettin Şahin

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Aydemir Çoban, E., Şahin, F. (2018). Cancer Stem Cells in Metastasis Therapy. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 2. Advances in Experimental Medicine and Biology(), vol 1089. Springer, Cham. https://doi.org/10.1007/5584_2018_279

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Published: 26 September 2018
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