Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1119)


Biomaterials are key components in tissue engineering and regenerative medicine applications, with the intended purpose of reducing the burden of disease and enhancing the quality of life of a large number of patients. The success of many regenerative medicine strategies, such as cell-based therapies, artificial organs, and engineered living tissues, is highly dependent on the ability to design or produce suitable biomaterials that can support and guide cells during tissue healing and remodelling processes. This chapter presents an overview about basic research concerning the use of different biomaterials for tissue engineering and regenerative medicine applications. Starting from a historical perspective, the chapter introduces the basic principles of designing biomaterials for tissue regeneration approaches. The main focus is set on describing the main classes of biomaterials that have been applied in regenerative medicine, including natural and synthetic polymers, bioactive ceramics, and composites. For each class of biomaterials, some of the most important physicochemical and biological properties are presented. Finally, some challenges and concerns that remain in this field are presented and discussed.


Biomaterials Regenerative medicine Scaffold Tissue engineering 



Biphasic calcium phosphate


Bone morphogenetic protein 2


Calcium phosphate


Carbon nanofibers


Carbon nanotubes


Diamond-like carbon


Extracellular matrix


Foreign body responses










Human-induced pluripotent stem cells


Mesoporous carbon nanomaterials


Microcomputed tomography


Matrix metalloproteinase


Mesenchymal stem cells


Multi-walled carbon nanotubes.




Polyethylene glycol


Polyethylene oxide










Platelet-rich plasma


Quantum dots


Single-walled carbon nanotubes



A. Mobasheri has been funded from the following sources: The European Commission Framework 7 programme (EU FP7; HEALTH.2012.2.4.5-2, project number 305815; Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases). The Innovative Medicines Initiative Joint Undertaking under grant agreement No. 115770, resources of which are composed of financial contribution from the European Union’s Seventh Framework programme (FP7/2007–2013) and EFPIA companies’ in-kind contribution. A. Mobasheri also wishes to acknowledge funding from the European Commission through a Marie Curie Intra-European Fellowship for Career Development grant (project number 625746; acronym: CHONDRION; FP7-PEOPLE-2013-IEF) and support from the European Social Fund according to the activity ‘Improvement of researchers’ qualification by implementing world-class R&D projects’ of Measure No. 09.3.3-LMT-K-712 (grant application code: 09.3.3-LMT-K-712-01-0157, agreement No. DOTSUT-215) and the Lithuanian Research Council through the European Social Fund to support the strategic activity ‘Development of a nanobiosensor: a multiplex analysis of diagnostic biomarkers for personalization of osteoarthritis therapy’, (grant application code: 01.2.2-LMT-K-718-02-0022).


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Cellular and Molecular Research CenterIran University of Medical Sciences (IUMS)TehranIran
  2. 2.Bioengineering Research Group, Nanotechnology and Advanced Materials DepartmentMaterials and Energy Research Center (MERC)TehranIran
  3. 3.Laboratory for Stem Cell Research, Department of Health Science and TechnologyAalborg UniversityAalborgDenmark
  4. 4.The D-BOARD FP7 ConsortiumUniversity of SurreyGuildfordUK
  5. 5.The APPROACH IMI ConsortiumUniversity of SurreyGuildfordUK
  6. 6.Faculty of Health and Medical SciencesUniversity of SurreyGuildford/SurreyUK
  7. 7.Arthritis Research UK Centre for Sport, Exercise and OsteoarthritisQueen’s Medical CentreNottinghamUK
  8. 8.Department of Regenerative MedicineState Research Institute Centre for Innovative MedicineVilniusLithuania
  9. 9.Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in MedicineIran University of Medical Sciences (IUMS)TehranIran

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