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Cell Biology and Translational Medicine, Volume 4 pp 1–19Cite as

Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends

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Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1119))

Abstract

Biomaterials are key components in tissue engineering and regenerative medicine applications, with the intended purpose of reducing the burden of disease and enhancing the quality of life of a large number of patients. The success of many regenerative medicine strategies, such as cell-based therapies, artificial organs, and engineered living tissues, is highly dependent on the ability to design or produce suitable biomaterials that can support and guide cells during tissue healing and remodelling processes. This chapter presents an overview about basic research concerning the use of different biomaterials for tissue engineering and regenerative medicine applications. Starting from a historical perspective, the chapter introduces the basic principles of designing biomaterials for tissue regeneration approaches. The main focus is set on describing the main classes of biomaterials that have been applied in regenerative medicine, including natural and synthetic polymers, bioactive ceramics, and composites. For each class of biomaterials, some of the most important physicochemical and biological properties are presented. Finally, some challenges and concerns that remain in this field are presented and discussed.

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Abbreviations

BCP:

Biphasic calcium phosphate

BMP-2:

Bone morphogenetic protein 2

CaP:

Calcium phosphate

CNFs:

Carbon nanofibers

CNTs:

Carbon nanotubes

DLC:

Diamond-like carbon

ECM:

Extracellular matrix

FBRs:

Foreign body responses

GAGs:

Glycosaminoglycans

GAL:

Galactoxylose

GLU:

Glucan

HA:

Hydroxyapatite

hiPSCs:

Human-induced pluripotent stem cells

MCNs:

Mesoporous carbon nanomaterials

Micro-CT:

Microcomputed tomography

MMP:

Matrix metalloproteinase

MSCs:

Mesenchymal stem cells

MWCNTs:

Multi-walled carbon nanotubes.

PCL:

Polycaprolactone

PEG:

Polyethylene glycol

PEO:

Polyethylene oxide

PGA:

Polyglycolide

PLA:

Polylactide

PNIPAAm:

Poly(N-isopropylacrylamide)

POE:

Polyoxyethylene

PRP:

Platelet-rich plasma

QDs:

Quantum dots

SWCNTs:

Single-walled carbon nanotubes

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Funding

A. Mobasheri has been funded from the following sources: The European Commission Framework 7 programme (EU FP7; HEALTH.2012.2.4.5-2, project number 305815; Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases). The Innovative Medicines Initiative Joint Undertaking under grant agreement No. 115770, resources of which are composed of financial contribution from the European Union’s Seventh Framework programme (FP7/2007–2013) and EFPIA companies’ in-kind contribution. A. Mobasheri also wishes to acknowledge funding from the European Commission through a Marie Curie Intra-European Fellowship for Career Development grant (project number 625746; acronym: CHONDRION; FP7-PEOPLE-2013-IEF) and support from the European Social Fund according to the activity ‘Improvement of researchers’ qualification by implementing world-class R&D projects’ of Measure No. 09.3.3-LMT-K-712 (grant application code: 09.3.3-LMT-K-712-01-0157, agreement No. DOTSUT-215) and the Lithuanian Research Council through the European Social Fund to support the strategic activity ‘Development of a nanobiosensor: a multiplex analysis of diagnostic biomarkers for personalization of osteoarthritis therapy’, (grant application code: 01.2.2-LMT-K-718-02-0022).

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  2. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  3. Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark

    Cristian Pablo Pennisi

  4. The D-BOARD FP7 Consortium, University of Surrey, Guildford, UK

    Ali Mobasheri

  5. The APPROACH IMI Consortium, University of Surrey, Guildford, UK

    Emma Budd & Ali Mobasheri

  6. Faculty of Health and Medical Sciences, University of Surrey, Guildford/Surrey, UK

    Emma Budd & Ali Mobasheri

  7. Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen’s Medical Centre, Nottingham, UK

    Ali Mobasheri

  8. Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

    Ali Mobasheri

  9. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Masoud Mozafari

Authors
  1. Maryam Rahmati
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  2. Cristian Pablo Pennisi
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  3. Emma Budd
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  4. Ali Mobasheri
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  5. Masoud Mozafari
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Corresponding authors

Correspondence to Ali Mobasheri or Masoud Mozafari .

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Editors and Affiliations

  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Rahmati, M., Pennisi, C.P., Budd, E., Mobasheri, A., Mozafari, M. (2018). Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 4. Advances in Experimental Medicine and Biology(), vol 1119. Springer, Cham. https://doi.org/10.1007/5584_2018_278

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