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Simvastatin Therapy and Bronchoalveolar Lavage Fluid Biomarkers in Chronic Obstructive Pulmonary Disease

  • Iwona Patyk
  • Cezary Rybacki
  • Agata Kalicka
  • Agnieszka Rzeszotarska
  • Jolanta Korsak
  • Andrzej ChciałowskiEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1150)

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive disease underlain by airway inflammation. Despite trials with new generations of anti-inflammatory drugs to alleviate the disease burden, the effective curative treatment remains elusive. In this context, the aim of this study was to assess the influence of simvastatin, a leading member of the family of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, known to display anti-inflammatory and immunomodulatory activity, on symptoms and lung function, as well as the proportion of inflammatory cells, cytokines, proteolytic enzymes, and surfactant protein D (SP-D) content in bronchoalveolar lavage fluid (BALF) in COPD patients. There were 50 patients with moderate-to-severe airway obstructions included into the study, subdivided into simvastatin-treated (Zocor – MSD; 40 mg daily) and control simvastatin-untreated groups, other treatment being equal. Pulmonary functions tests and bronchofiberoscopy with BALF procedure were performed before and after 3–month–long treatment in both groups. The major finding was that simvastatin treatment caused a distinct increase in the airway content of SP-D. Further effects, albeit smaller in magnitude, consisted of reductions in the proportion of airway neutrophils and in MMP-9 content, all with a benefit of improved score in the disease activity assessment test. There were no appreciable changes noted in lung function or dyspnea perception, which could be ascribed to simvastatin treatment. We conclude that statin’s anti-inflammatory and surfactant homeostasis preserving properties may offer promise as an adjunctive treatment in COPD patients. The SP-D content in BALF has a potential to become a marker of COPD inflammatory activity and treatment monitoring.

Keywords

COPD Cytokines Fiber-optic bronchoscopy Matrix Metalloproteinases Pulmonary function Statins Surfactant protein 

Notes

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Copyright information

© Springer Nature Switzerland AG  2018

Authors and Affiliations

  • Iwona Patyk
    • 1
  • Cezary Rybacki
    • 1
  • Agata Kalicka
    • 1
  • Agnieszka Rzeszotarska
    • 2
  • Jolanta Korsak
    • 2
  • Andrzej Chciałowski
    • 3
    Email author
  1. 1.Department of Pneumology and AllergologyTenth Military Clinical HospitalBydgoszczPoland
  2. 2.Department of Clinical TransfusiologyMilitary Institute of MedicineWarsawPoland
  3. 3.Department of Infectious Diseases and AllergologyMilitary Institute of MedicineWarsawPoland

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