Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1119)


Wound healing is a complex process with the considerable burden on healthcare system. There are several cellular therapy methods that have been introduced to treat different types of wounds. Despite the advantages of cellular therapy, it is needed to overcome different limitations of this method such as; tumorigenicity and immune rejection. Accordingly, scientists have suggested cell-based vesicles and exosomes. Exosomes can promote proliferation, migration, and angiogenesis process in the wound environment. They have also some advantages such as the potential for drug and gene delivery, easy to storage, and stability in the body. These advantages make them as a novel approach in regenerative medicine without the limitations of cellular therapy. In this review, the authors emphasize on biological properties of MSC-exosomes and their therapeutic effects as a new strategy for wound regeneration.


Exosomes Mesenchymal stromal cells Regenerative medicine Transport vesicles Wound healing 



Angiopoietin 1


Adipose-derived stem cells


Blood-Brain Barrier


Bone marrow-derived mesenchymal stem cells


Composite collagen–hydroxyapatite


Extra-cellular matrix


Diabetic foot ulcers


Epidermal growth factor


Extra-cellular vesicles


Food and Drug Administration


Fibroblast growth factor 2


Insulin growth factor 1


Interlukin 1


Interlukin 6


Induced pluripotent stem cells


Mesenchymal stem cells


Platelet-derived growth factor


Signal transducer and activator of transcription 3


Transforming growth factor beta 1


Tumor necrosis factor-alpha


Umbilical cord blood mesenchymal stem cells


Vascular endothelial growth factor


Mesenchymal stem cells-derived exosomes


Hepatocyte growth factor


Insulin-like growth factor 1


Stromal cell-derived factor 1



The authors would like to acknowledge Dr. Mohsen khorshidi, Firooze Hajipour, Rasta Arjmand, and Maryam Afshari for their kind support.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Brain and Spinal Cord Injury Research Center, Neuroscience InstituteTehran University of Medical SciencesTehranIran
  2. 2.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  4. 4.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran

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