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The Great Harmony in Translational Medicine: Biomaterials and Stem Cells

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Book cover Cell Biology and Translational Medicine, Volume 4

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1119))

Abstract

Thanks to novel approaches and emerging technologies, tissue engineering and regenerative medicine have made a great effort to regenerate damaged tissue or organ with no donor needed. The approaches involve two fundamental components: bioengineered scaffolds and stem cells. Bioengineered scaffolds which can also be enriched with bioactive molecules such as cytokines, growth factors, and so on have been fabricated using a wide range of synthetically or naturally derived biodegradable and biocompatible polymers. These scaffolds should support cell attachment, migration, proliferation, and/or differentiation by mimicking the duty of native extracellular matrix. Stem cells are the other significant players in formation of the neotissue. Stem cells, bone marrow, or adipose-derived mesenchymal stem cells, in particular, have been widely used for this purpose. Recently, investigators have preferred to use progenitor cells including cardiac and neural cells in tissue engineering and regenerative medicine applications. The synergy of the bioengineered scaffolds and autologous stem cells is crucial for the successful reconstruction of damaged or missing tissues.

This review summarizes a number of excellent studies conducted on current applications of bioengineered scaffolds, novel fabrication methods, stem cells used in tissue engineering and regenerative medicine, and the future of the tissue-engineered products.

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Abbreviations

3D:

Three-dimensional

AMSCs:

Adipose-derived mesenchymal stem cells

CSCs:

Cardiac stem cells

ECM:

Extracellular matrix

ECSs:

Embryonic stem cells

FDA:

Food and Drug Administration

FDM:

Fused deposition modeling

hAMSCs:

Human adipose-derived mesenchymal stem cells

HUVECs:

Human umbilical vein endothelial cells

iPSCs:

Induced pluripotent stem cells

MSCs:

Mesenchymal stem cells

NCSs:

Neural stem cells

NPCs:

Neural progenitor cells

PFP:

Powder-fusion printing

SCI:

Spinal cord injury

SLA:

Stereolithographic Apparatus

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Acknowledgments

The authors would like to thank Prof. Kaan C. Emregul for his comments and language proofreading.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Regenerative Biomaterials Laboratory, Department of Bioengineering, Engineering Faculty, Canakkale Onsekiz Mart University, Canakkale, Turkey

    Evren Erten & Yavuz Emre Arslan

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  1. Evren Erten
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Correspondence to Yavuz Emre Arslan .

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  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Erten, E., Arslan, Y.E. (2018). The Great Harmony in Translational Medicine: Biomaterials and Stem Cells. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 4. Advances in Experimental Medicine and Biology(), vol 1119. Springer, Cham. https://doi.org/10.1007/5584_2018_231

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