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Adipose Tissue-Derived Stromal Cells for Wound Healing

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Cell Biology and Translational Medicine, Volume 4

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1119))

Abstract

Skin as the outer layer covers the body. Wounds can affect this vital organ negatively and disrupt its functions. Wound healing as a biological process is initiated immediately after an injury. This process consists of three stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors such as infection, obesity and diabetes mellitus can interfere with these stages and impede the normal healing process which results in chronic wounds. Financial burden on both patients and health care systems, negative biologic effect on the patient’s general health status and reduction in quality of life are a number of issues which make chronic wounds as a considerable challenge. During recent years, along with advances in the biomedical sciences, various surgical and non-surgical therapeutic methods have been suggested. All of these suggested treatments have their own advantages and disadvantages. Recently, cell-based therapies and regenerative medicine represent promising approaches to wound healing. Accordingly, several types of mesenchymal stem cells have been used in both preclinical and clinical settings for the treatment of wounds. Adipose-derived stromal cells are a cost-effective source of mesenchymal stem cells in wound management which can be easily harvest from adipose tissues through the less invasive processes with high yield rates. In addition, their ability to secrete multiple cytokines and growth factors, and differentiation into skin cells make them an ideal cell type to use in wound treatment. This is a concise overview on the application of adipose-derived stromal cells in wound healing and their role in the treatment of chronic wounds.

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Abbreviations

AMPs::

Antimicrobial peptides

ASCs::

Adipose-derived stromal Cells

bFGF::

Basic fibroblast growth factor

BM-MSCs::

Bone marrow-derived mesenchymal stem cells

DFU::

Diabetic foot ulcer

ECM::

Extracellular Matrix

EGF::

Epidermal growth factor

FGF2::

Fibroblast growth factor-2

GAGs::

Glycosaminoglycans

HBOT::

Hyperbaric oxygen therapy

HBSs::

Hypertrophic burn scars

HGF::

Epidermal growth factor

HTSs::

Hypertrophic scars

IGF::

Insulin-like growth factor

IL-1α::

Interleukin 1 alpha

IL-6::

Interleukin 6

KGF::

Keratinocyte growth factor

MMPs::

Matrix metalloproteinases

MSC::

Mesenchymal stromal cells

NPWT::

Negative pressure wound therapy

NRGs::

Neuregulins

PDGF::

Platelet-derived growth factor

PMNs::

Polymorphonuclear leukocytes

PU::

Pressure ulcer

SDF1::

Stromal-derived factor 1

SSI::

Surgical site infection

SVF::

Stromal vascular fraction

TGF-β::

Transforming growth factor beta

TIMPs::

Tissue inhibitor of metalloproteinases

TNF-α::

Tumor necrosis factor

VEGF::

Vascular endothelial growth factor

VLU::

Venous leg ulcers

VPF::

Vascular permeability factor

CAL::

Cell-Assisted Lipotransfer

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Acknowledgement

The authors would like to acknowledge Dr. Mohsen khorshidi, Dr. Salman Radkarim, Rasta Arjmand, and Maryam Afshari for their kind support.

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Authors and Affiliations

  1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Parisa Goodarzi

  2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Sepideh Alavi-Moghadam, Masoumeh Sarvari, Akram Tayanloo Beik, Hamidreza Aghayan & Babak Arjmand

  3. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Khadijeh Falahzadeh & Babak Arjmand

  4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Moloud Payab

  5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Bagher Larijani

  6. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

    Kambiz Gilany

  7. Health Research Institute, Thalassemia and Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fakher Rahim

  8. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hossein Adibi

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  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Goodarzi, P. et al. (2018). Adipose Tissue-Derived Stromal Cells for Wound Healing. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 4. Advances in Experimental Medicine and Biology(), vol 1119. Springer, Cham. https://doi.org/10.1007/5584_2018_220

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