Adipose Tissue-Derived Stromal Cells for Wound Healing

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1119)


Skin as the outer layer covers the body. Wounds can affect this vital organ negatively and disrupt its functions. Wound healing as a biological process is initiated immediately after an injury. This process consists of three stages: inflammation, proliferation, remodeling. Generally, these three stages occur continuously and timely. However, some factors such as infection, obesity and diabetes mellitus can interfere with these stages and impede the normal healing process which results in chronic wounds. Financial burden on both patients and health care systems, negative biologic effect on the patient’s general health status and reduction in quality of life are a number of issues which make chronic wounds as a considerable challenge. During recent years, along with advances in the biomedical sciences, various surgical and non-surgical therapeutic methods have been suggested. All of these suggested treatments have their own advantages and disadvantages. Recently, cell-based therapies and regenerative medicine represent promising approaches to wound healing. Accordingly, several types of mesenchymal stem cells have been used in both preclinical and clinical settings for the treatment of wounds. Adipose-derived stromal cells are a cost-effective source of mesenchymal stem cells in wound management which can be easily harvest from adipose tissues through the less invasive processes with high yield rates. In addition, their ability to secrete multiple cytokines and growth factors, and differentiation into skin cells make them an ideal cell type to use in wound treatment. This is a concise overview on the application of adipose-derived stromal cells in wound healing and their role in the treatment of chronic wounds.


Adipose tissue Chronic disease Mesenchymal stromal cell Regenerative medicines Wound healing 



Antimicrobial peptides


Adipose-derived stromal Cells


Basic fibroblast growth factor


Bone marrow-derived mesenchymal stem cells


Diabetic foot ulcer


Extracellular Matrix


Epidermal growth factor


Fibroblast growth factor-2




Hyperbaric oxygen therapy


Hypertrophic burn scars


Epidermal growth factor


Hypertrophic scars


Insulin-like growth factor


Interleukin 1 alpha


Interleukin 6


Keratinocyte growth factor


Matrix metalloproteinases


Mesenchymal stromal cells


Negative pressure wound therapy




Platelet-derived growth factor


Polymorphonuclear leukocytes


Pressure ulcer


Stromal-derived factor 1


Surgical site infection


Stromal vascular fraction


Transforming growth factor beta


Tissue inhibitor of metalloproteinases


Tumor necrosis factor


Vascular endothelial growth factor


Venous leg ulcers


Vascular permeability factor


Cell-Assisted Lipotransfer



The authors would like to acknowledge Dr. Mohsen khorshidi, Dr. Salman Radkarim, Rasta Arjmand, and Maryam Afshari for their kind support.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Brain and Spinal Cord Injury Research Center, Neuroscience InstituteTehran University of Medical SciencesTehranIran
  2. 2.Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  4. 4.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  6. 6.Reproductive Biotechnology Research Center, Avicenna Research InstituteACECRTehranIran
  7. 7.Health Research Institute, Thalassemia and Hemoglobinopathy Research CenterAhvaz Jundishapur University of Medical SciencesAhvazIran
  8. 8.Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran

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