Skip to main content
SpringerLink
Log in

Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

  • Chapter
  • First Online:
Cell Biology and Translational Medicine, Volume 3

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1107))

Abstract

Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

3D:

Three-dimensional

ESCs:

Embryonic stem cells

IPSCs:

Induced pluripotent stem cells

HSCs:

Hematopoietic stem cells

SGZ:

Sub-granular zone

ECM:

Extracellular matrix

BM-MSCs:

Bone marrow mesenchymal stem cells

AFSC:

Amniotic fluid derived stem cells

ADSCs:

Adipose-derived stem cells

HA:

Hyaluronic acid

MMPs:

Metalloproteases

GAGs:

Glycosaminoglycans

PEG:

Poly (ethylene glycol)

PVA:

poly (vinyl alcohol)

PLA:

poly (lactic acid)

PLGA:

poly (lactic-co-glycolic acid)

PLC:

Polycaprolactone

BG:

Bioactive glass

CNTs:

Carbon nanotubes

DLC:

Diamond-like carbon

CNFs:

Carbon nanofibers

References

  • Ahadian S, Obregón R, Ramón-Azcón J, Salazar G, Shiku H, Ramalingam M, Matsue T (2016) Carbon nanotubes and graphene-based nanomaterials for stem cell differentiation and tissue regeneration. J Nanosci Nanotechnol 16(9):8862–8880

    Article  CAS  Google Scholar 

  • Almada AE, Wagers AJ (2016) Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. Nat Rev Mol Cell Biol 17(5):267

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amer LD, Holtzinger A, Keller G, Mahoney MJ, Bryant SJ (2015) Enzymatically degradable poly (ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates. Acta Biomater 22:103–110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ansari S, Diniz IM, Chen C, Aghaloo T, Wu BM, Shi S, Moshaverinia A (2017) Alginate/hyaluronic acid hydrogel delivery system characteristics regulate the differentiation of periodontal ligament stem cells toward chondrogenic lineage. J Mater Sci Mater Med 28(10):162

    Article  CAS  PubMed  Google Scholar 

  • Araña M, Gavira JJ, Peña E, González A, Abizanda G, Cilla M, Pérez MM, Albiasu E, Aguado N, Casado M (2014) Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction. Biomaterials 35(1):143–151

    Article  CAS  PubMed  Google Scholar 

  • Bajaj P, Schweller RM, Khademhosseini A, West JL, Bashir R (2014) 3D biofabrication strategies for tissue engineering and regenerative medicine. Annu Rev Biomed Eng 16:247–276

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bara JJ, Richards RG, Alini M, Stoddart MJ (2014) Concise review: bone marrow-derived mesenchymal stem cells change phenotype following in vitro culture: implications for basic research and the clinic. Stem Cells 32(7):1713–1723

    Article  CAS  PubMed  Google Scholar 

  • Bauer S, Park J, Faltenbacher J, Berger S, von der Mark K, Schmuki P (2009) Size selective behavior of mesenchymal stem cells on ZrO 2 and TiO2 nanotube arrays. Integr Biol 1(8-9):525–532

    Article  CAS  Google Scholar 

  • Best S, Porter A, Thian E, Huang J (2008) Bioceramics: past, present and for the future. J Eur Ceram Soc 28(7):1319–1327

    Article  CAS  Google Scholar 

  • Bidarra SJ, Barrias CC, Granja PL (2014) Injectable alginate hydrogels for cell delivery in tissue engineering. Acta Biomater 10(4):1646–1662

    Article  CAS  PubMed  Google Scholar 

  • Blanpain C, Fuchs E (2014) Plasticity of epithelial stem cells in tissue regeneration. Science 344(6189):1242281

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Boddohi S, Moore N, Johnson PA, Kipper MJ (2009) Polysaccharide-based polyelectrolyte complex nanoparticles from chitosan, heparin, and hyaluronan. Biomacromolecules 10(6):1402–1409

    Article  CAS  PubMed  Google Scholar 

  • Bosetti M, Cannas M (2005) The effect of bioactive glasses on bone marrow stromal cells differentiation. Biomaterials 26(18):3873–3879

    Article  CAS  PubMed  Google Scholar 

  • Broughton KM, Sussman MA (2016) Empowering adult stem cells for myocardial regeneration V2. 0: success in small steps. Circ Res 118(5):867–880

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calatayud MP, Sanz B, Raffa V, Riggio C, Ibarra MR, Goya GF (2014) The effect of surface charge of functionalized Fe 3 O 4 nanoparticles on protein adsorption and cell uptake. Biomaterials 35(24):6389–6399

    Article  CAS  PubMed  Google Scholar 

  • Cao S, Zhu H (2014) Frontiers in biomaterials: the design, synthetic strategies and biocompatibility of polymer scaffolds for biomedical application. Bentham Science Publishers

    Google Scholar 

  • Chagastelles PC, Nardi NB (2011) Biology of stem cells: an overview. Kidney Int Suppl 1(3):63–67

    Article  Google Scholar 

  • Chang H-I, Wang Y (2011) Cell responses to surface and architecture of tissue engineering scaffolds. Regenerative medicine and tissue engineering-cells and biomaterials. InTech

    Google Scholar 

  • Chen F-M, Jin Y (2010) Periodontal tissue engineering and regeneration: current approaches and expanding opportunities. Tissue Eng B Rev 16(2):219–255

    Article  CAS  Google Scholar 

  • Chen Z, Rodriguez ADV, Li X, Erclik T, Fernandes VM, Desplan C (2016) A unique class of neural progenitors in the Drosophila optic lobe generates both migrating neurons and glia. Cell Rep 15(4):774–786

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheng J, Türkel N, Hemati N, Fuller MT, Hunt AJ, Yamashita YM (2008) Centrosome misorientation reduces stem cell division during ageing. Nature 456(7222):599

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chung HJ, Park TG (2007) Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Adv Drug Deliv Rev 59(4-5):249–262

    Article  CAS  PubMed  Google Scholar 

  • Chung YG, Lanza RP, Klimanskaya IV (2017) Derivation of embryonic stem cells and embryo-derived cells. Google Patents

    Google Scholar 

  • da Silva Meirelles L, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20(5–6):419–427

    Article  CAS  Google Scholar 

  • Das S, Pati F, Choi Y-J, Rijal G, Shim J-H, Kim SW, Ray AR, Cho D-W, Ghosh S (2015) Bioprintable, cell-laden silk fibroin–gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs. Acta Biomater 11:233–246

    Article  CAS  PubMed  Google Scholar 

  • Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X (2014) Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater 10(4):1558–1570

    Article  CAS  PubMed  Google Scholar 

  • Dolatshahi-Pirouz A, Kolind K, Pennisi CP, Duroux M, Zachar V, Foss M, Besenbacher F (2015) Synthesis of nano-and micro-scale topographies by combining colloidal lithography and glancing angle deposition (GLAD). Adv Eng Mater 17(1):8–13. https://doi.org/10.1002/adem.201400044

    Article  CAS  Google Scholar 

  • Dong Y, Rodrigues M, Li X, Kwon SH, Kosaric N, Khong S, Gao Y, Wang W, Gurtner GC (2017) Injectable and tunable gelatin hydrogels enhance stem cell retention and improve cutaneous wound healing. Adv Funct Mater 27(24)

    Google Scholar 

  • Dorozhkin SV (2015) Calcium orthophosphate bioceramics. Ceram Int 41(10):13913–13966

    Article  CAS  Google Scholar 

  • Drury JL, Mooney DJ (2003) Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 24(24):4337–4351

    Article  CAS  PubMed  Google Scholar 

  • Ducheyne P (2015) Comprehensive biomaterials. Elsevier

    Google Scholar 

  • Estes BT, Diekman BO, Gimble JM, Guilak F (2010) Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc 5(7):1294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fleming HE, Janzen V, Celso CL, Guo J, Leahy KM, Kronenberg HM, Scadden DT (2008) Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2(3):274–283

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Forbes SJ, Rosenthal N (2014) Preparing the ground for tissue regeneration: from mechanism to therapy. Nat Med 20(8):857

    Article  CAS  PubMed  Google Scholar 

  • Garg T, Singh O, Arora S, Murthy R (2012) Scaffold: a novel carrier for cell and drug delivery. Crit Rev Ther Drug Carrier Syst 29(1)

    Google Scholar 

  • Gizzatov A, Hernández-Rivera M, Keshishian V, Mackeyev Y, Law JJ, Guven A, Sethi R, Qu F, Muthupillai R, da Graça Cabreira-Hansen M (2015) Surfactant-free Gd 3+-ion-containing carbon nanotube MRI contrast agents for stem cell labeling. Nanoscale 7(28):12085–12091

    Article  CAS  PubMed  Google Scholar 

  • Guillén G, Giménez B, López Caballero M, Montero García P (2011) Functional and bioactive properties of collagen and gelatin from alternative sources: a review

    Google Scholar 

  • Guo L, Zhao RC, Wu Y (2011) The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol 39(6):608–616

    Article  CAS  PubMed  Google Scholar 

  • Ha TLB, Quan TM, Vu D, Si D, Andrades J (2013) Naturally derived biomaterials: preparation and application. Regen Med Tissue Eng:247–274

    Google Scholar 

  • Hao Z, Song Z, Huang J, Huang K, Panetta A, Gu Z, Wu J (2017) The scaffold microenvironment for stem cell based bone tissue engineering. Biomater Sci 5(8):1382–1392

    Article  CAS  PubMed  Google Scholar 

  • He W, Benson R (2014) Polymeric biomaterials. William Andrew Publishing, Oxford

    Google Scholar 

  • Hewitt Z, Priddle H, Thomson AJ, Wojtacha D, McWhir J (2007) Ablation of undifferentiated human embryonic stem cells: exploiting innate immunity against the gal α1-3Galβ1-4GlcNAc-R (α-Gal) epitope. Stem Cells 25(1):10–18

    Article  CAS  PubMed  Google Scholar 

  • Hintze V, Moeller S, Schnabelrauch M, Bierbaum S, Viola M, Worch H, Scharnweber D (2009) Modifications of hyaluronan influence the interaction with human bone morphogenetic protein-4 (hBMP-4). Biomacromolecules 10(12):3290–3297

    Article  CAS  PubMed  Google Scholar 

  • Ho SS, Murphy KC, Binder BY, Vissers CB, Leach JK (2016) Increased survival and function of mesenchymal stem cell spheroids entrapped in instructive alginate hydrogels. Stem Cells Transl Med 5(6):773–781

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoefling M, Iori F, Corni S, Gottschalk K-E (2010) Interaction of amino acids with the Au (111) surface: adsorption free energies from molecular dynamics simulations. Langmuir 26(11):8347–8351

    Article  CAS  PubMed  Google Scholar 

  • Houreh AB, Labbaf S, Ting H-K, Ejeian F, Jones JR, Esfahani M-HN (2017) Influence of calcium and phosphorus release from bioactive glasses on viability and differentiation of dental pulp stem cells. J Mater Sci 52(15):8928–8941

    Article  CAS  Google Scholar 

  • Howard D, Buttery LD, Shakesheff KM, Roberts SJ (2008) Tissue engineering: strategies, stem cells and scaffolds. J Anat 213(1):66–72

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hsueh Y-Y, Chang Y-J, Huang T-C, Fan S-C, Wang D-H, Chen J-JJ, Wu C-C, Lin S-C (2014) Functional recoveries of sciatic nerve regeneration by combining chitosan-coated conduit and neurosphere cells induced from adipose-derived stem cells. Biomaterials 35(7):2234–2244

    Article  CAS  PubMed  Google Scholar 

  • Jang J, Park H-J, Kim S-W, Kim H, Park JY, Na SJ, Kim HJ, Park MN, Choi SH, Park SH (2017) 3D printed complex tissue construct using stem cell-laden decellularized extracellular matrix bioinks for cardiac repair. Biomaterials 112:264–274

    Article  CAS  PubMed  Google Scholar 

  • Kelleher CM, Vacanti JP (2010) Engineering extracellular matrix through nanotechnology. J R Soc Interface: rsif20100345

    Google Scholar 

  • Khang G, Lee SJ, Kim MS, Lee HB (2006) Biomaterials: tissue engineering and scaffolds. Encyclopedia of Medical devices and instrumentation

    Google Scholar 

  • Kim J, Lin B, Kim S, Choi B, Evseenko D, Lee M (2015) TGF-β1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells. J Biol Eng 9(1):1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim J, Song SH, Jin Y, Park H-J, Yoon H, Jeon S, Cho S-W (2016) Multiphoton luminescent graphene quantum dots for in vivo tracking of human adipose-derived stem cells. Nanoscale 8(16):8512–8519

    Article  CAS  PubMed  Google Scholar 

  • Kitagawa F, Takei S, Imaizumi T, Tabata Y (2012) Chondrogenic differentiation of immortalized human mesenchymal stem cells on zirconia microwell substrata. Tissue Eng Part C Methods 19(6):438–448

    Article  CAS  PubMed  Google Scholar 

  • Komine F, Blatz MB, Matsumura H (2010) Current status of zirconia-based fixed restorations. J Oral Sci 52(4):531–539

    Article  PubMed  Google Scholar 

  • Kong Y, Xu R, Darabi MA, Zhong W, Luo G, Xing MM, Wu J (2016) Fast and safe fabrication of a free-standing chitosan/alginate nanomembrane to promote stem cell delivery and wound healing. Int J Nanomedicine 11:2543

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lane SW, Williams DA, Watt FM (2014) Modulating the stem cell niche for tissue regeneration. Nat Biotechnol 32(8):795

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lapidot T, Petit I (2002) Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 30(9):973–981

    Article  CAS  PubMed  Google Scholar 

  • Londono R, Badylak SF (2015) Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Ann Biomed Eng 43(3):577–592

    Article  PubMed  Google Scholar 

  • Louvi A, Artavanis-Tsakonas S (2006) Notch signalling in vertebrate neural development. Nat Rev Neurosci 7(2):93

    Article  CAS  PubMed  Google Scholar 

  • Lyons F, Partap S, O'Brien FJ (2008) Part 1: scaffolds and surfaces. Technol Health Care 16(4):305–317

    PubMed  Google Scholar 

  • Mandal BB, Kundu SC (2009) Cell proliferation and migration in silk fibroin 3D scaffolds. Biomaterials 30(15):2956–2965

    Article  CAS  PubMed  Google Scholar 

  • Mao AS, Mooney DJ (2015) Regenerative medicine: current therapies and future directions. Proc Natl Acad Sci 112(47):14452–14459

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Martino S, D'Angelo F, Armentano I, Kenny JM, Orlacchio A (2012) Stem cell-biomaterial interactions for regenerative medicine. Biotechnol Adv 30(1):338–351

    Article  CAS  PubMed  Google Scholar 

  • Meder F, Daberkow T, Treccani L, Wilhelm M, Schowalter M, Rosenauer A, Mädler L, Rezwan K (2012) Protein adsorption on colloidal alumina particles functionalized with amino, carboxyl, sulfonate and phosphate groups. Acta Biomater 8(3):1221–1229

    Article  CAS  PubMed  Google Scholar 

  • Mohammed MK, Shao C, Wang J, Wei Q, Wang X, Collier Z, Tang S, Liu H, Zhang F, Huang J (2016) Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis 3(1):11–40

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moodley YP, Armitage JD, Tan D (2017) The biology and potential clinical applications of mesenchymal stromal cells in diseases of the lung. Biol Ther Appl Mesenchymal Cells:770–786

    Google Scholar 

  • Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R (1996) Novel approach to fabricate porous sponges of poly (D, L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 17(14):1417–1422

    Article  CAS  PubMed  Google Scholar 

  • Mudo G, Bonomo A, Di Liberto V, Frinchi M, Fuxe K, Belluardo N (2009) The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain. J Neural Transm 116(8):995–1005

    Article  CAS  PubMed  Google Scholar 

  • Murphy WL, McDevitt TC, Engler AJ (2014) Materials as stem cell regulators. Nat Mater 13(6):547

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Necas J, Bartosikova L, Brauner P, Kolar J (2008) Hyaluronic acid (hyaluronan): a review. Vet Med 53(8):397–411

    Article  CAS  Google Scholar 

  • Nie C, Zhang G, Yang D, Liu T, Liu D, Xu J, Zhang J (2015) Targeted delivery of adipose-derived stem cells via acellular dermal matrix enhances wound repair in diabetic rats. J Tissue Eng Regen Med 9(3):224–235

    Article  CAS  PubMed  Google Scholar 

  • Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, Muskheli V, Pabon L, Reinecke H, Murry CE (2007) Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J 21(7):1345–1357

    Article  CAS  PubMed  Google Scholar 

  • Ohishi M, Schipani E (2010) Bone marrow mesenchymal stem cells. J Cell Biochem 109(2):277–282

    CAS  PubMed  Google Scholar 

  • Onoshima D, Yukawa H, Baba Y (2015) Multifunctional quantum dots-based cancer diagnostics and stem cell therapeutics for regenerative medicine. Adv Drug Deliv Rev 95:2–14

    Article  CAS  PubMed  Google Scholar 

  • Orlacchio A, Bernardi G, Orlacchio A, Martino S (2010) Stem cells and neurological diseases. Discov Med 9(49):546–553

    PubMed  Google Scholar 

  • Paige KT, Cima LG, Yaremchuk MJ, Schloo BL, Vacanti JP, Vacanti CA (1996) De novo cartilage generation using calcium alginate-chondrocyte constructs. Plast Reconstr Surg 97(1):168–178. discussion 179-180

    Article  CAS  PubMed  Google Scholar 

  • Parenteau-Bareil R, Gauvin R, Berthod F (2010) Collagen-based biomaterials for tissue engineering applications. Materials 3(3):1863–1887

    Article  CAS  PubMed Central  Google Scholar 

  • Park MV, Annema W, Salvati A, Lesniak A, Elsaesser A, Barnes C, McKerr G, Howard CV, Lynch I, Dawson KA (2009) In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. Toxicol Appl Pharmacol 240(1):108–116

    Article  CAS  PubMed  Google Scholar 

  • Patenaude M, Hoare T (2012) Injectable, mixed natural-synthetic polymer hydrogels with modular properties. Biomacromolecules 13(2):369–378

    Article  CAS  PubMed  Google Scholar 

  • Peer D (2012) Handbook of harnessing biomaterials in nanomedicine: preparation, toxicity, and applications, CRC Press

    Google Scholar 

  • Rahmati M, Samadikuchaksaraei A, Mozafari M (2016) Insight into the interactive effects of β-glycerophosphate molecules on thermosensitive chitosan-based hydrogels. Bioinspired, Biomimetic Nanobiomater 5(2):67–73

    Article  Google Scholar 

  • Rahmati M, Milan PB, Samadikuchaksaraei A, Goodarzi V, Saeb MR, Kargozar S, Kaplan DL, Mozafari M (2017) ionically crosslinked thermoresponsive chitosan hydrogels formed in situ: a conceptual basis for deeper understanding. Macromol Mater Eng 302(11)

    Google Scholar 

  • Rana D, Zreiqat H, Benkirane-Jessel N, Ramakrishna S, Ramalingam M (2017) Development of decellularized scaffolds for stem cell-driven tissue engineering. J Tissue Eng Regen Med 11(4):942–965

    Article  CAS  PubMed  Google Scholar 

  • Ranella A, Barberoglou M, Bakogianni S, Fotakis C, Stratakis E (2010) Tuning cell adhesion by controlling the roughness and wettability of 3D micro/nano silicon structures. Acta Biomater 6(7):2711–2720

    Article  CAS  PubMed  Google Scholar 

  • Ravichandran R, Sundarrajan S, Venugopal JR, Mukherjee S, Ramakrishna S (2010) Applications of conducting polymers and their issues in biomedical engineering. J R Soc Interface: rsif20100120

    Google Scholar 

  • Richardson S, Hodgkinson T, White L, Shakesheff K, Hoyland J (2018) Use of PLGA microspheres to deliver a biologic to direct adipose-derived stem cell differentiation for intervertebral disc regeneration. Orthopaedic Proceedings, The British Editorial Society of Bone & Joint Surgery

    Google Scholar 

  • Rinaudo M (2006) Chitin and chitosan: properties and applications. Prog Polym Sci 31(7):603–632

    Article  CAS  Google Scholar 

  • Rosa AI, Gonçalves J, Cortes L, Bernardino L, Malva JO, Agasse F (2010) The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells. J Neurosci 30(13):4573–4584

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rossant J, Tam PP (2017) New insights into early human development: lessons for stem cell derivation and differentiation. Cell Stem Cell 20(1):18–28

    Article  CAS  PubMed  Google Scholar 

  • Sarasam A, Madihally SV (2005) Characterization of chitosan–polycaprolactone blends for tissue engineering applications. Biomaterials 26(27):5500–5508

    Article  CAS  PubMed  Google Scholar 

  • Sekuła M, Zuba-Surma EK (2018) Biomaterials and stem cells: promising tools in tissue engineering and biomedical applications. Biomaterials in regenerative medicine, InTech

    Google Scholar 

  • Singh Dhillon G, Kaur S, Jyoti Sarma S, Kaur Brar S, Verma M, Yadagiri Surampalli R (2013) Recent development in applications of important biopolymer chitosan in biomedicine, pharmaceuticals and personal care products. Curr Tissue Eng 2(1):20–40

    Article  Google Scholar 

  • Singh A, Elisseeff J (2010) Biomaterials for stem cell differentiation. J Mater Chem 20(40):8832–8847

    Article  CAS  Google Scholar 

  • Singh VK, Kalsan M, Kumar N, Saini A, Chandra R (2015) Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery. Front Cell Dev Biol 3:2

    Article  PubMed  PubMed Central  Google Scholar 

  • Snyder TN, Madhavan K, Intrator M, Dregalla RC, Park D (2014) A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair. J Biol Eng 8(1):10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sullivan MJ (2008) Banking on cord blood stem cells. Nat Rev Cancer 8(7):555

    Article  CAS  PubMed  Google Scholar 

  • Sun J, Tan H (2013) Alginate-based biomaterials for regenerative medicine applications. Materials 6(4):1285–1309

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tabar V, Studer L (2014) Pluripotent stem cells in regenerative medicine: challenges and recent progress. Nat Rev Genet 15(2):82

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tan H, Marra KG (2010) Injectable, biodegradable hydrogels for tissue engineering applications. Materials 3(3):1746–1767

    Article  CAS  PubMed Central  Google Scholar 

  • Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD (2015) Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep 11(1):33–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tøndervik A, Klinkenberg G, Aarstad OA, Drabløs F, Ertesvåg H, Ellingsen TE, Skjåk-Bræk G, Valla S, Sletta H (2010) Isolation of mutant alginate lyases with cleavage specificity for di-guluronic acid linkages. J Biol Chem 285(46):35284–35292

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsuji W, Rubin JP, Marra KG (2014) Adipose-derived stem cells: Implications in tissue regeneration. World J Stem Cells 6(3):312

    Article  PubMed  PubMed Central  Google Scholar 

  • Vallet-Regí M, Ruiz-Hernández E (2011) Bioceramics: from bone regeneration to cancer nanomedicine. Adv Mater 23(44):5177–5218

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Zhu D, Paul A, Cai L, Enejder A, Yang F, Heilshorn SC (2017) Covalently adaptable elastin-like protein–hyaluronic acid (ELP–HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery. Adv Funct Mater 27(28)

    Google Scholar 

  • Wilson A, Trumpp A (2006) Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 6(2):93

    Article  CAS  PubMed  Google Scholar 

  • Yamashita YM (2009) The centrosome and asymmetric cell division. Prion 3(2):84–88

    Article  PubMed  PubMed Central  Google Scholar 

  • Yao Q, Cosme JG, Xu T, Miszuk JM, Picciani PH, Fong H, Sun H (2017) Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation. Biomaterials 115:115–127

    Article  CAS  PubMed  Google Scholar 

  • Yi R, Fuchs E (2011) MicroRNAs and their roles in mammalian stem cells. J Cell Sci 124(11):1775–1783

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu J, Chen F, Wang X, Dong N, Lu C, Yang G, Chen Z (2016) Synthesis and characterization of MMP degradable and maleimide cross-linked PEG hydrogels for tissue engineering scaffolds. Polym Degrad Stab 133:312–320

    Article  CAS  Google Scholar 

  • Zachar V, Duroux M, Emmersen J, Rasmussen JG, Pennisi CP, Yang S, Fink T (2011) Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering. Expert Opin Biol Ther 11(6):775–786

    Article  CAS  PubMed  Google Scholar 

  • Zhang J, Li L (2008) Stem cell niche: microenvironment and beyond. J Biol Chem 283(15):9499–9503

    Article  CAS  PubMed  Google Scholar 

  • Zhang Z, Hu J, Ma PX (2012) Nanofiber-based delivery of bioactive agents and stem cells to bone sites. Adv Drug Deliv Rev 64(12):1129–1141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhou X, Wang J, Fang W, Tao Y, Zhao T, Xia K, Liang C, Hua J, Li F, Chen Q (2018) Genipin cross-linked type II collagen/chondroitin sulfate composite hydrogel-like cell delivery system induces differentiation of adipose-derived stem cells and regenerates degenerated nucleus pulposus. Acta Biomaterialia

    Google Scholar 

  • Zhu J, Marchant RE (2011) Design properties of hydrogel tissue-engineering scaffolds. Expert Rev Med Devices 8(5):607–626

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  2. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  3. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran

    Maryam Rahmati & Masoud Mozafari

  4. Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark

    Cristian Pablo Pennisi

  5. The D-BOARD FP7 Consortium, Surrey, UK

    Ali Mobasheri

  6. The APPROACH IMI Consortium, Surrey, UK

    Ali Mobasheri

  7. Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK

    Ali Mobasheri

  8. Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen’s Medical Centre, Nottingham, UK

    Ali Mobasheri

  9. Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

    Ali Mobasheri

Authors
  1. Maryam Rahmati
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cristian Pablo Pennisi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ali Mobasheri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masoud Mozafari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ali Mobasheri or Masoud Mozafari .

Editor information

Editors and Affiliations

  1. Ottawa Hospital Research Institute, Osgoode, ON, Canada

    Kursad Turksen

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Rahmati, M., Pennisi, C.P., Mobasheri, A., Mozafari, M. (2018). Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 3. Advances in Experimental Medicine and Biology(), vol 1107. Springer, Cham. https://doi.org/10.1007/5584_2018_215

Download citation

Publish with us

Policies and ethics

Search

Navigation