Regenerative Medicine Applications of Mesenchymal Stem Cells

Hosseini, Samaneh; Taghiyar, Leila; Safari, Fatemeh; Baghaban Eslaminejad, Mohamadreza

doi:10.1007/5584_2018_213

Samaneh Hosseini⁷,
Leila Taghiyar⁷,
Fatemeh Safari⁸ &
…
Mohamadreza Baghaban Eslaminejad⁷

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1089))

1947 Accesses
34 Citations

Abstract

A major research challenge is to develop therapeutics that assist with healing damaged tissues and organs because the human body has limited ability to restore the majority of these tissues and organs to their original state. Tissue engineering (TE) and regenerative medicine (RM) promises to offer efficient therapeutic biological strategies that use mesenchymal stem cells (MSCs). MSCs possess the capability for self-renewal, multilineage differentiation, and immunomodulatory properties that make them attractive for clinical applications. They have been extensively investigated in numerous preclinical and clinical settings in an attempt to overcome their challenges and promote tissue regeneration and repair. This review explores the exciting opportunities afforded by MSCs, their desirable properties as cellular therapeutics in RM, and implicates their potential use in clinical practice. Here, we attempt to identify challenges and issues that determine the clinical efficacy of MSCs as treatment for skeletal and non-skeletal tissues.

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Abbreviations

AKI:: Acute kidney injury
ALS:: Amyotrophic lateral sclerosis
ABGs:: Autologous bone grafts
ACI:: Autologous chondrocyte implantation
BM:: Bone marrow
BMMC:: Bone marrow mononuclear cells
BMT:: Bone marrow transplantation
CPCs:: Cardiac progenitor cells
CCR:: C-C chemokine receptor type
CKD:: Chronic kidney disease
CXCR:: C-X-C chemokine receptor type
DCM:: Dilated cardiomyopathy
DMD:: Duchenne muscular dystrophy
ESCs:: Embryonic stem cells
EPCs:: Endothelial progenitor cells
ECM:: Extracellular matrix
FTSW:: Full-thickness skin wounds
GVHD:: Graft versus host disease
GFP:: Green fluorescence protein
HF:: Heart failure
HCELL:: Hematopoietic cell E-/L-selectin ligand
HGF:: Hepatocyte growth factor
hAD-MSCs:: human adipose derived-MSCs
HA:: Hydroxyapatite
iPSCs:: induced pluripotent stem cells
IGF-1:: Insulin-like growth factor 1
ISCT:: International Society for Cellular Therapy
IA:: Intra-arterial
IC:: Intracoronary
IV:: Intravenous
MHC:: Major histocompatibility complex
MSCs:: Mesenchymal stem cells
MMPs:: Metalloproteinases
MSC-CM:: MSCs-conditioned medium
MS:: Multiple sclerosis
MI:: Myocardial infarction
NIH:: National Institute of Health
NYHA:: New York Heart Association
NO:: Nitric oxide
OA:: Osteoarthritis
OI:: Osteogenesis imperfecta
PDGF:: Platelet-derived growth factor
PSCs:: Pluripotent stem cells
PCL:: Poly-ε-caprolactone
ciPTEC:: Proximal tubule epithelial cells
RM:: Regenerative medicine
SCs:: Satellite cells
SECs:: Sinusoidal endothelial cells
SDF-1:: Stromal derived factor-1
TA:: Tibialis anterior
TE:: Tissue engineering
TGF-β:: Transforming growth factor-beta
UC:: Umbilical cord
VCAM-1:: Vascular cell adhesion molecule 1
VEGF:: Vascular endothelial growth factor

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Authors and Affiliations

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Samaneh Hosseini, Leila Taghiyar & Mohamadreza Baghaban Eslaminejad
Bone Biology & Orthopaedic Research, Department for BioMedical Research, University of Bern, Bern, Switzerland
Fatemeh Safari

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Samaneh Hosseini
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Leila Taghiyar
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Fatemeh Safari
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Mohamadreza Baghaban Eslaminejad
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Correspondence to Mohamadreza Baghaban Eslaminejad .

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Ottawa Hospital Research Institute, Osgoode, ON, Canada
Kursad Turksen

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Hosseini, S., Taghiyar, L., Safari, F., Baghaban Eslaminejad, M. (2018). Regenerative Medicine Applications of Mesenchymal Stem Cells. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 2. Advances in Experimental Medicine and Biology(), vol 1089. Springer, Cham. https://doi.org/10.1007/5584_2018_213

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DOI: https://doi.org/10.1007/5584_2018_213
Published: 17 May 2018
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-04169-4
Online ISBN: 978-3-030-04170-0
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