Transition of Left Ventricular Ejection Fraction in Heart Failure

  • Yasuhiko Sakata
  • Kanako Tsuji
  • Kotaro Nochioka
  • Hiroaki ShimokawaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1067)


Along with a worldwide epidemiological transition and dramatic increase in the elderly population, both the incidence and prevalence of heart failure (HF) are increasing worldwide. This epidemic of HF is characterized by an increase of HF with preserved left ventricular ejection fraction (LVEF) (HFpEF) and a decrease of HF with reduced LVEF (HFrEF). Of note, transition between HFpEF and HFrEF has been recently highlighted, since it significantly relates with prognosis. Our recent studies indicated that temporary changes in LVEF are common and associated with prognosis in patients with HF. In this chapter, we summarize recent findings on temporal changes in LVEF and their prognostic impact in HF patients, acknowledging that further studies are needed to fully elucidate the pathophysiology of LVEF recovery and deterioration to improve clinical outcomes of HF patients, and also to develop therapies targeting novel pathways of myocardial recovery.


Epidemiologic transition Heart failure Ischemic heart disease Left ventricular ejection fraction Prognosis 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Yasuhiko Sakata
    • 1
  • Kanako Tsuji
    • 1
  • Kotaro Nochioka
    • 1
  • Hiroaki Shimokawa
    • 1
    Email author
  1. 1.Department of Cardiovascular Medicine and Department of Evidence-based Cardiovascular MedicineTohoku University Graduate School of MedicineSendaiJapan

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