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P2Y11 Receptors: Properties, Distribution and Functions

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Protein Reviews

Part of the book series: Advances in Experimental Medicine and Biology ((PROTRE,volume 1051))

Abstract

The P2Y11 receptor is a G protein-coupled receptor that is stimulated by endogenous purine nucleotides, particularly ATP. Amongst P2Y receptors it has several unique properties; (1) it is the only human P2Y receptor gene that contains an intron in the coding sequence; (2) the gene does not appear to be present in the rodent genome; (3) it couples to stimulation of both phospholipase C and adenylyl cyclase. Its absence in mice and rats, along with a limited range of selective pharmacological tools, has hampered the development of our knowledge and understanding of its properties and functions. Nonetheless, through a combination of careful use of the available tools, suppression of receptor expression using siRNA and genetic screening for SNPs, possible functions of native P2Y11 receptors have been identified in a variety of human cells and tissues. Many are in blood cells involved in inflammatory responses, consistent with extracellular ATP being a damage-associated signalling molecule in the immune system. Thus proposed potential therapeutic applications relate, in the main, to modulation of acute and chronic inflammatory responses.

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Abbreviations

ADP:

adenosine 5′-diphosphate

AMI:

acute myocardial infarction

ATP:

adenosine 5′-triphosphate

cP2Y11 receptor:

canine P2Y11 receptor

DAMPs:

damage-associated molecular patterns

GPCR:

G protein-coupled receptors

GTP:

guanosine 5′-triphosphate

hP2Y11 receptor:

human P2Y11 receptor

IP3 :

inositol 1,4,5-trisphosphate

IPs:

inositol phosphates

ITP:

inosine 5′-triphosphate

LXA4 :

lipoxin A4

MDC:

Malmo Diet and Cancer

NAADP+ :

nicotinic acid adenine dinucleotide phosphate

NAD+ :

nicotinamide adenine dinucleotide

PKC:

protein kinase C

PLC:

phospholipase C

SNPs:

single nucleotide polymorphisms

UDP:

uridine 5′diphosphate

UTP:

uridine 5′-triphosphate

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The author declares that he has no conflict of interests.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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  1. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK

    Charles Kennedy

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  1. Biochem and Mol Biol, Baylor College of Medicine, Houston, Texas, USA

    M. Zouhair Atassi

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Kennedy, C. (2017). P2Y11 Receptors: Properties, Distribution and Functions. In: Atassi, M. (eds) Protein Reviews. Advances in Experimental Medicine and Biology(), vol 1051. Springer, Singapore. https://doi.org/10.1007/5584_2017_89

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