Dental Pulp Stem Cells and Neurogenesis

  • Ibrahim MortadaEmail author
  • Rola Mortada
  • Mohamad Al Bazzal
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1083)


Recent advances in regenerative medicine and cell-based therapy are bringing promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive source of these cells since collecting mesenchymal stem cells from this site is a noninvasive procedure which can be done following a common surgical extraction of supernumerary or wisdom teeth. Thus tissue sacrifice is very low and several cytotypes can be obtained owing to these cells’ multipotency, in addition to the fact that they can be cryopreserved and stored for long periods. Mesenchymal stem cells have high proliferation rates making them favorable for clinical application. These multipotent cells present in a biological waste constitute an appropriate support in the management of many neurological disorders. After a brief overview on the different types of dental stem cells, this chapter will focus on the characteristics of dental pulp stem cells, their handling and applications in neural tissue engineering, as well as neural induction protocols leading to their potential therapeutic use in the management of neurological diseases.


Biology DPSCs Experimental medicine Regenerative medicine Stem cells 



Minimum essential medium, alpha modification


All-trans retinoic acid


Bone marrow mesenchymal stem cells


Dental follicle progenitor cells


Dental follicle stem cells


Dulbecco’s modified Eagle’s medium


Dimethyl sulfoxide


Dental stem cells


Extracellular matrix


Epidermal growth factor


Microtubule-associated protein 2


Mesenchymal stem cells


Neuron-specific enolase


Periodontal ligament stem cells


Rat bone marrow mesenchymal stem cells


Stem cells from apical papilla


Stem cells from human exfoliated deciduous teeth


Tenascin C


Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Ibrahim Mortada
    • 1
    Email author
  • Rola Mortada
    • 2
  • Mohamad Al Bazzal
    • 2
  1. 1.Faculty of MedicineAmerican University of BeirutBeirutLebanon
  2. 2.Lebanese University School of DentistryBeirutLebanon

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