Acute and Chronic Effects of Oral Erdosteine on Ciliary Beat Frequency, Cough Sensitivity and Airway Reactivity
Erdosteine as a mucolytic agent that decreases mucus viscosity and facilitates mucus expulsion from the airways by cough or ciliary movement. Our objective was to determine whether erdosteine can directly contribute to mucus clearance. We addressed the issue by monitoring acute and chronic effects of erdosteine on ciliary beat frequency (CBF), cough sensitivity, and airway smooth muscle reactivity. The experiments were performed in healthy guinea pigs. Erdosteine (10 mg/kg) was administrated orally in a single dose or daily through 7 days. The cough reflex and specific airway resistance were evaluated in vivo. The CBF in tracheal brushed samples and the contractile response of tracheal smooth muscle stripes to bronchoconstrictive mediators were evaluated in vitro. We found that neither acute nor chronic erdosteine treatment had a significant effect on cough sensitivity and airway reactivity. However, in the vitro condition, erdosteine increased CBF and reduced tracheal smooth muscle contractility; the effects were more pronounced after chronic treatment. We conclude that erdosteine may directly contribute to mucus clearance by CBF stimulation. Although erdosteine has no effect on cough reflex sensitivity, its mild bronchodilator and mucolytic properties may promote effective cough.
KeywordsAirway reactivity Airway smooth muscles Ciliary beat frequency Cough sensitivity Erdosteine Mucus clearance
Supported by grants: APVV 0305-12, VEGA 1/0165/14 a MZ 2012/35- UK, CERK II, UK/62/2016; by the project Biomedical Center Martin – ITMS: 26220220187 entitled ‘We support research activities in Slovakia’, co-financed from EU sources.
Conflicts of Interest
The authors declare no conflicts of interest in relation to this article.
- Olivieri D, Del Donno M, Casalini A, D’Ippolito R, Fregnan GB (1991) Activity of erdosteine on mucociliary transport in patients affected by chronic bronchitis. Respir Int Rev Thorac Dis 58:91–94Google Scholar
- Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy J (2015) Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med 7:276ra27CrossRefPubMedPubMedCentralGoogle Scholar