A Synonymous Mutation at Bovine Alpha Vitronectin Domain of Integrin Host Receptor (ITGAV) Gene Effect the Susceptibility of Foot-and-Mouth Disease in Crossbred Cattle

  • Rani Singh
  • Rani Alex
  • Umesh Singh
  • Sushil Kumar
  • Gyanendra Singh Sengar
  • T. V. Raja
  • R. R. Alyethodi
  • Ashish Kumar
  • Rajib Deb
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1057)

Abstract

Integrins are one of the major biologically active proteins responsible for Foot-and-mouth disease virus (FMDV)- host interaction. Out of various heterodimeric integrins discovered, αVβ6 heterodimer serves as the chief receptor for FMDV host tropism. Earlier studies reported that, SNPs at beta 6 subunit (ITGB6) were associated with the occurrence of the diseases in cattle. In this study we report the association between a synonymous SNP (rs719257875) at bovine alpha vitronectin domain of integrin receptor (ITGAV) gene and FMD susceptibility in cattle. A strong significant association (P < 0.0001) of the genotypes with FMD susceptibility were obtained, where the CC genotypes play a major role in occurrence of FMD in crossbred cattle.

Keywords

ITGAV FMDV Synonymous SNP Cattle 

Notes

Acknowledgement

This project was funded by Department of Science and Technology, New Delhi, Govt. of India (SR/WOS-A/LS-437/2012 (G)). The authors are thankful to Director, ICAR-CIRC, Meerut for providing necessary facilities for conducting the study.

Ethical Standard Statement

All animal experiments were performed following protocols approved by the Institutional Ethical committee.

Conflict of Interest

We declared that none of the authors have any kind of conflict of interest interest for submission of this present manuscript.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Rani Singh
    • 1
  • Rani Alex
    • 1
  • Umesh Singh
    • 1
  • Sushil Kumar
    • 1
  • Gyanendra Singh Sengar
    • 1
  • T. V. Raja
    • 1
  • R. R. Alyethodi
    • 1
  • Ashish Kumar
    • 1
  • Rajib Deb
    • 1
  1. 1.Molecular Genetics LaboratoryICAR-Central Institute for Research on CattleMeerutIndia

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