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Clinical Management of Pulmonary Disorders and Diseases pp 71–76Cite as

Thyroid Autoimmunity in Girls with Turner Syndrome

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Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1022))

Abstract

Turner syndrome is associated with increased incidence of autoimmune diseases, especially those of the thyroid gland. The aim of this study was to assess the prevalence of thyroid autoimmunity among pediatric patients with Turner syndrome. The study was retrospective and included 41 girls with Turner syndrome aged 6–18 years. Free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (TPO-Ab) antibodies, anti-thyroglobulin (TG-Ab) antibodies, and karyotype were investigated. The correlation between karyotype and incidence of thyroid autoimmunity was also examined. Eleven patients (26.8%) were positive for TPO-Ab and/or TG-Ab. Three girls from that subgroup were euthyroid, 5 had subclinical hypothyroidism, and 3 were diagnosed with overt hypothyroidism. Out of these 11 patients affected by thyroid autoimmunity, 6 girls had mosaic karyotype with X-isochromosome (n = 4) or with deletions (n = 2), and 5 had the 45,X karyotype. The study findings confirmed a high incidence of thyroid autoimmunity in girls with Turner syndrome, but we failed to observe an association between the incidence of thyroid autoimmunity and karyotype. We conclude that it is important to monitor thyroid function in patients with Turner syndrome because they are prone to develop hypothyroidism.

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Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Pediatrics and Endocrinology, Medical University of Warsaw, 63A Żwirki i Wigury Street, 02-091, Warsaw, Poland

    Ewelina Witkowska-Sędek, Ada Borowiec, Anna Kucharska, Karolina Chacewicz, Małgorzata Rumińska & Beata Pyrżak

  2. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland

    Urszula Demkow

Authors
  1. Ewelina Witkowska-Sędek
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  2. Ada Borowiec
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  3. Anna Kucharska
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  4. Karolina Chacewicz
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  5. Małgorzata Rumińska
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  6. Urszula Demkow
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  7. Beata Pyrżak
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Correspondence to Ewelina Witkowska-Sędek .

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Editors and Affiliations

  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Witkowska-Sędek, E. et al. (2017). Thyroid Autoimmunity in Girls with Turner Syndrome. In: Pokorski, M. (eds) Clinical Management of Pulmonary Disorders and Diseases. Advances in Experimental Medicine and Biology(), vol 1022. Springer, Cham. https://doi.org/10.1007/5584_2017_42

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