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The Robust Potential of Mesenchymal Stem Cell-Loaded Constructs for Hard Tissue Regeneration After Cancer Removal

  • Samaneh Hosseini
  • Mohammad Amin Shamekhi
  • Shahrbanoo Jahangir
  • Fatemeh Bagheri
  • Mohamadreza Baghaban Eslaminejad
Chapter
Part of the Advances in Experimental Medicine and Biology book series

Abstract

Malignant bone tumors, although quite rare, are one of the causes of death in children and adolescents. Surgery as a common and primary treatment for removal of virtually bone cancer cause large bone defects. Thus, restoration of hard tissues like bone and cartilage after surgical tumor resection needs efficient therapeutic approaches. Tissue engineering (TE) is a powerful approach which has provided hope for restoration, maintenance, or improvement of damaged tissues. This strategy generally supplies a three-dimensional scaffold as an active substrate to support cell recruitment, infiltration, and proliferation for neo-tissues. The scaffold mimics the natural extracellular matrix (ECM) of tissue which needs to be regenerated. The use of potent cell sources such as mesenchymal stem cells (MSCs) has also led to remarkable progresses in hard tissue regeneration. Combination of living cells and various biomaterials have continuously evolved over the past decades to improve the process of regeneration. This chapter describes various strategies used in TE and highlights recent advances in cell-loaded constructs. We herein focus on cell-based scaffold approach utilized in hard tissue engineering and parameters determining a clinically efficient outcome. Also, we attempt to identify the potential as well as shortcomings of pre-loaded scaffolds for future therapeutic applications.

Keywords

Mesenchymal stem cells Hard tissue regeneration Cancer Removal Stem cell loaded constructs 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Samaneh Hosseini
    • 1
  • Mohammad Amin Shamekhi
    • 2
  • Shahrbanoo Jahangir
    • 1
  • Fatemeh Bagheri
    • 3
  • Mohamadreza Baghaban Eslaminejad
    • 1
  1. 1.Department of Stem Cells and Developmental Biology, Cell Science Research CenterRoyan Institute for Stem Cell Biology and Technology, ACECRTehranIran
  2. 2.Department of Polymer EngineeringIslamic Azad UniversitySarvestanIran
  3. 3.Department of Biotechnology, Faculty of Chemical EngineeringTarbiat Modares UniversityTehranIran

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