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New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling

  • Chapter
  • First Online:
Heart Failure: From Research to Clinical Practice

Part of the book series: Advances in Experimental Medicine and Biology ((AIM,volume 1067))

Abstract

Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.

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Authors and Affiliations

  1. Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy

    Jessica Gambardella, Bruno Trimarco & Gaetano Santulli

  2. Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Fisciano, Italy

    Jessica Gambardella & Guido Iaccarino

  3. Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Forch 525, 10461, New York, NY, USA

    Gaetano Santulli

Authors
  1. Jessica Gambardella
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  2. Bruno Trimarco
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  3. Guido Iaccarino
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  4. Gaetano Santulli
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Correspondence to Gaetano Santulli .

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Editors and Affiliations

  1. Department of Clinical Sciences and Education, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

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Gambardella, J., Trimarco, B., Iaccarino, G., Santulli, G. (2017). New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling. In: Islam, M. (eds) Heart Failure: From Research to Clinical Practice. Advances in Experimental Medicine and Biology(), vol 1067. Springer, Cham. https://doi.org/10.1007/5584_2017_106

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  • DOI: https://doi.org/10.1007/5584_2017_106

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