New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling

  • Jessica Gambardella
  • Bruno Trimarco
  • Guido Iaccarino
  • Gaetano SantulliEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1067)


Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.


Calcium RyR Mitochondria SerCa Contraction Heart Failure 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Jessica Gambardella
    • 1
    • 2
  • Bruno Trimarco
    • 1
  • Guido Iaccarino
    • 2
  • Gaetano Santulli
    • 1
    • 3
    Email author
  1. 1.Department of Advanced Biomedical Sciences“Federico II” UniversityNaplesItaly
  2. 2.Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of SalernoFiscianoItaly
  3. 3.Department of Medicine, Albert Einstein College of MedicineNew YorkUSA

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