Abstract
Superimposed preeclampsia refers to women with chronic arterial hypertension (primary or secondary) who develop preeclampsia (PE). Because hypertension affects 5–15 % of pregnancies, it is itself a matter of concern. However, this concern should be permanent, given the increased risk of the hypertension worsening and, particularly, the appearance of superimposed PE. The search for factors that underlie or promote the development of this disorder has been the subject of intense research. However, despite the wealth of knowledge, the cause or causes remain to be determined.
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Abbreviations
- ACOG:
-
American College of Obstetricians and Gynecologists
- eNOS:
-
endothelial nitric oxide synthase
- IUGR:
-
intra-uterine growth restriction
- LR:
-
likelihood ratio
- NO:
-
nitric oxide
- PE:
-
preeclampsia
- PI:
-
pulsatility index
- PlGF:
-
placental growth factor
- sFlt-1:
-
soluble fms-like tyrosine kinase
- sPE:
-
superimposed preeclampsia
- UtA:
-
uterine artery
- −ve:
-
negative
- +ve:
-
positive
- VEGF:
-
vascular endothelial growth factor.
References
Aardema MW, Saro MC, Lander M, De Wolf BT, Oosterhof H, Aarnoudse JG (2004) Second trimester Doppler ultrasound screening of the uterine arteries differentiates between subsequent normal and poor outcomes of hypertensive pregnancy: two different pathophysiological entities? Clin Sci (Lond) 106(4):377–382
American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy (2013) Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol 122(5):1122–1131
Amorim MM, Santos LC, Faúndes A (1999) Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia. Am J Obstet Gynecol 180(5):1283–1288
Anumba DO, Lincoln K, Robson SC (2010) Predictive value of clinical and laboratory indices at first assessment in women referred with suspected gestational hypertension. Hypertens Pregnancy 29(2):163–179
Balasch J, Gratacós E (2011) Delayed childbearing: effects on fertility and the outcome of pregnancy. Fetal Diagn Ther 29(4):263–273
Bramham K, Parnell B, Nelson-Piercy C, Seed PT, Poston L, Chappell LC (2014) Chronic hypertension and pregnancy outcomes: systematic review and meta-analysis. BMJ 348:g2301
Brosens I, Pijnenborg R, Vercruysse L, Romero R (2011) The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol 204(3):193–201
Chappell LC, Enye S, Seed P, Briley AL, Poston L, Shennan AH (2008) Adverse perinatal outcomes and risk factors for preeclampsia in women with chronic hypertension: a prospective study. Hypertension 51(4):1002–1009. doi:10.1161/HYPERTENSIONAHA.107.107565
Cnossen JS, Morris RK, ter Riet G, Mol BW, van der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS (2008) Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 178(6):701–711
de Mouzon J, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V, Kupka M, Nygren KG, Nyboe Andersen A, European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE) (2010) Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod 25(8):1851–1862
Edwards EW, DiPette DJ, Townsend RR, Cohen DL (2014) Top 10 landmark studies in hypertension. J Am Soc Hypertens 8(6):437–447
Ferrer RL, Sibai BM, Mulrow CD, Chiquette E, Stevens KR, Cornell J (2000) Management of mild chronic hypertension during pregnancy: a review. Obstet Gynecol 96(5 Pt 2):849–860
Frusca T, Soregaroli M, Platto C, Enterri L, Lojacono A, Valcamonico A (2003) Uterine artery velocimetry in patients with gestational hypertension. Obstet Gynecol 102(1):136–140
Gómez O, Figueras F, Fernández S, Bennasar M, Martínez JM, Puerto B, Gratacós E (2008) Reference ranges for uterine artery mean pulsatility index at 11–41 weeks of gestation. Ultrasound Obstet Gynecol 32(2):128–132
Grummer MA, Sullivan JA, Magness RR, Bird IM (2009) Vascular endothelial growth factor acts through novel, pregnancy-enhanced receptor signalling pathways to stimulate endothelial nitric oxide synthase activity in uterine artery endothelial cells. Biochem J 417(2):501–511
Guedes-Martins L, Saraiva J, Gaio R, Macedo F, Almeida H (2014a) Uterine artery impedance at very early clinical pregnancy. Prenat Diagn 34(8):719–725
Guedes-Martins L, Cunha A, Saraiva J, Gaio R, Macedo F, Almeida H (2014b) Internal iliac and uterine arteries Doppler ultrasound in the assessment of normotensive and chronic hypertensive pregnant women. Sci Rep 4:3785
Guedes-Martins L, Gaio R, Saraiva J, Cerdeira S, Matos L, Silva E, Macedo F, Almeida H (2015) Reference ranges for uterine artery pulsatility index during the menstrual cycle: a cross-sectional study. PLoS One 10(3), e0119103
Hajjar I, Kotchen JM, Kotchen TA (2006) Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health 27:465–490
Istance D, Theisens H (2008) Ageing OECD societies in trends shaping education 2008. Centre for Educational Research and Innovation. Organization for Economic Co-Operation and Development, OECD, pp 13–20
Jacobsson B, Ladfors L, Milsom I (2004) Advanced maternal age and adverse perinatal outcome. Obstet Gynecol 104(4):727–733
Karumanchi SA, Maynard SE, Stillman IE, Epstein FH, Sukhatme VP (2005) Preeclampsia: a renal perspective. Kidney Int 67(6):2101–2113
Konje JC, Kaufmann P, Bell SC, Taylor DJ (2001) A longitudinal study of quantitative uterine blood flow with the use of color power angiography in appropriate for gestational age pregnancies. Am J Obstet Gynecol 185(3):608–613
Lain KY, Roberts JM (2002) Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA 287(24):3183–3186
Leow MK (2015) Environmental origins of hypertension: phylogeny, ontogeny and epigenetics. Hypertens Res 38:299
Li H, Gudnason H, Olofsson P, Dubiel M, Gudmundsson S (2005) Increased uterine artery vascular impedance is related to adverse outcome of pregnancy but is present in only one-third of late third-trimester preeclamptic women. Ultrasound Obstet Gynecol 25(5):459–463
Mandala M, Osol G (2012) Physiological remodelling of the maternal uterine circulation during pregnancy. Basic Clin Pharmacol Toxicol 110(1):12–18
Mathews TJ, Hamilton BE (2009) Delayed childbearing: more women are having their first child later in life. NCHS data brief, no 21. Hyattsville, MD. National Center for Health Statistics 21:1–8
Meler E, Figueras F, Mula R, Crispi F, Benassar M, Gómez O, Gratacós E (2010) Prognostic role of uterine artery Doppler in patients with preeclampsia. Fetal Diagn Ther 27(1):8–13
Menken J, Trussell J, Larsen U (1986) Age and infertility. Science 233(4771):1389–1394
National Institutes of Health Consensus Development Panel (2001) Antenatal corticosteroids revisited: repeat courses – National Institutes of Health Consensus Development Conference Statement, August 17–18, 2000. Obstet Gynecol 98(1):144–150
National Heart, Lung and Blood Institute (2001) Report of the working group on research on hypertension during pregnancy. http://www.nhlbi.nih.gov/resources/hyperten_preg/
Osol G, Mandala M (2009) Maternal uterine vascular remodeling during pregnancy. Physiology (Bethesda, Md) 24:58–71
Oyelese Y, Ananth CV (2006) Placental abruption. Obstet Gynecol 108(4):1005–1016
Palmer RM, Ashton DS, Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333(6174):664–666
Papageorghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening Group (2001) Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18(5):441–449
Papageorghiou AT, Yu CK, Erasmus IE, Cuckle HS, Nicolaides KH (2005) Assessment of risk for the development of pre-eclampsia by maternal characteristics and uterine artery Doppler. BJOG 112(6):703–709
Ray JG, Burrows RF, Burrows EA, Vermeulen MJ (2001) MOS HIP: McMaster outcome study of hypertension in pregnancy. Early Hum Dev 64(2):129–143
Rosenfeld CR, DeSpain K, Word RA, Liu XT (2012) Differential sensitivity to angiotensin II and norepinephrine in human uterine arteries. J Clin Endocrinol Metab 97(1):138–147
Samuel A, Lin C, Parviainen K, Jeyabalan A (2011) Expectant management of preeclampsia superimposed on chronic hypertension. J Matern Fetal Neonatal Med 24(7):907–911. doi:10.3109/14767058.2010.535874
Seely EW, Ecker J (2014) Chronic hypertension in pregnancy. Circulation 129(11):1254–1261
Seely EW, Solomon CG (2016) Improving the prediction of preeclampsia. N Engl J Med 374(1):83–84. doi:10.1056/NEJMe1515223
Sibai BM, Stella CL (2009) Diagnosis and management of atypical preeclampsia-eclampsia. Am J Obstet Gynecol 200(5):481.e1-7
Sibai B, Dekker G, Kupferminc M (2005) Pre-eclampsia. Lancet 365(9461):785–799
Smith GC, Yu CK, Papageorghiou AT, Cacho AM, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening Group (2007) Maternal uterine artery Doppler flow velocimetry and the risk of stillbirth. Obstet Gynecol 109(1):144–151
Sprague BJ, Phernetton TM, Magness RR, Chesler NC (2009) The effects of the ovarian cycle and pregnancy on uterine vascular impedance and uterine artery mechanics. Eur J Obstet Gynecol Reprod Biol 144(Suppl 1):S170–S178
Steer CV, Williams J, Zaidi J, Campbell S, Tan SL (1995) Intra-observer, interobserver, interultrasound transducer and intercycle variation in colour Doppler assessment of uterine artery impedance. Hum Reprod 10(2):479–481
van den Elzen HJ, Cohen-Overbeek TE, Grobbee DE, Quartero RW, Wladimiroff JW (1995) Early uterine artery Doppler velocimetry and the outcome of pregnancy in women aged 35 years and older. Ultrasound Obstet Gynecol 5(5):328–333
van Katwijk C, Peeters LL (1998) Clinical aspects of pregnancy after the age of 35 years: a review of the literature. Hum Reprod Update 4(2):185–194
Vodstrcil LA, Tare M, Novak J, Dragomir N, Ramirez RJ, Wlodek ME, Conrad KP, Parry LJ (2012) Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow. FASEB J 26(10):4035–4044
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Guedes-Martins, L. (2016). Superimposed Preeclampsia. In: Islam, M.S. (eds) Hypertension: from basic research to clinical practice. Advances in Experimental Medicine and Biology(), vol 956. Springer, Cham. https://doi.org/10.1007/5584_2016_82
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DOI: https://doi.org/10.1007/5584_2016_82
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