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Adherence to Treatment in Hypertension

  • Chapter
Hypertension: from basic research to clinical practice

Part of the book series: Advances in Experimental Medicine and Biology ((AIM,volume 956))

Abstract

The lack of adherence to treatment in hypertension affects approximately 30 % of patients. The elderly, those with several co-morbidities, social isolation, low incomes or depressive symptoms are the most vulnerable to this problem. There is no ideal method to quantify the adherence to the treatment. Indirect methods are recommended in clinical practice. Any intervention strategy should not blame the patient and try a collaborative approach. It is recommended to involve the patient in decision-making. The clinical interview style must be patient-centered including motivational techniques. The improvement strategies that showed greater effectiveness in the compliance of hypertension treatment were: treatment simplification, appointment reminders systems, blood pressure self-monitoring, organizational improvements and nurse and pharmacists care. The combination of different interventions are recommended against isolated interventions.

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References

  • Abel WM, Barksdale DJ (2012) Freedom of choice and adherence to the health regimen for African Americans with hypertension. Adv Nurs Sci 35(4):E1–E8. doi:10.1097/ANS.0b013e31826b842f

    Article  Google Scholar 

  • Aronow WS (2011) ACCF/AHA 2011 expert consensus document on hypertension in the elderly. J Am Coll Cardiol 57(20):2037–2114

    Article  PubMed  Google Scholar 

  • Banegas JR, Segura J, Ruilope LM, Luque M, Garcia-Robles R, Campo C et al (2004) Blood pressure control and physician management of hypertension in hospital hypertension units in Spain. Hypertension 43:1338–1344

    Article  CAS  PubMed  Google Scholar 

  • Baroletti S, Dell’Orfano H (2010) Medication adherence in cardiovascular disease. Circulation 121:1455

    Article  PubMed  Google Scholar 

  • Berg JS, Dischler J, Wagner DJ, Raia JJ, Palmer-Shevlin N (1993) Medication compliance: a healthcare problem. Ann Pharmacother 27(9 suppl):S1–S24

    CAS  PubMed  Google Scholar 

  • Berra K, Fletcher BJ, Hayman LL, Miller NH (2011) Global cardiovascular disease prevention: a call to action for nursing: the global burden of cardiovascular disease. J Cardiovasc Nurs 26:S1–S2

    Article  PubMed  Google Scholar 

  • Bond WS, Hussar DA (1991) Detection methods and strategies for improving medication compliance. Am J Hosp Pharm 48:1987–1988

    Google Scholar 

  • Bosworth H (2010) Improving patient treatment adherence. A clinician’s guide. Springer, New York. ISBN 978-1-4419-5865-5

    Book  Google Scholar 

  • Buchholz A, Vach W, Siegel A, Dürk T, Loh A, Buchholz A et al (2012) Implementation of shared decision making by physician training to optimise hypertension treatment. Study protocol of a cluster-RCT. Cardiovasc Disord 12:73. doi:10.1186/1471-2261-12-73

    Google Scholar 

  • Buhse S, Mühlhauser I, Kuniss N, Müller UA, Lehmann T, Liethmann K (2015) An informed shared decision making programme on the prevention of myocardial infarction for patients with type 2 diabetes in primary care: protocol of a cluster randomised, controlled trial. BMC Fam Pract 16:43. doi:10.1186/s12875-015-0257-2

    Article  PubMed  PubMed Central  Google Scholar 

  • Carter BL, Rogers M, Daly J, Zheng S, James PA (2009) The potency of team-based care interventions for hypertension: a meta-analysis. Arch Intern Med 169:1748–1755

    PubMed  PubMed Central  Google Scholar 

  • Chapman RH, Benner JS, Petrilla AS, Tierce JS, Collins SR, Battleman DS et al (2005) Predictors of adherence with antihypertensive and lipid-lowering therapy. Arch Intern Med 165:1147–1152

    Article  PubMed  Google Scholar 

  • Choo PW, Rand CS, Inui TS, Lee ML, Cain E (1999) Cordeiro – Breault et M to the validation of patient reports, automated adherence to antihypertensive therapy. Med Care 37(9):846–857

    Article  CAS  PubMed  Google Scholar 

  • Choudhry NK, Denberg TD, Qaseem A, Clinical Guidelines Committee of the American College of Physicians (2016) Improving adherence to therapy and clinical outcomes while containing costs: opportunities from the greater use of generic medications: best practice advice from the Clinical Guidelines Committee of the American College of Physicians. Ann Intern Med 164:41

    Article  PubMed  Google Scholar 

  • Chourdhy NK, Avon J, Glynn RJ et al (2011) Full coverage for preventive medication after myocardial infarction. N Engl J Med 365:2088

    Article  Google Scholar 

  • Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23:1296–1310

    Article  CAS  PubMed  Google Scholar 

  • Corrao G, Parodi A, Zambon A, Heiman F, Filippi A, Cricelli C et al (2010) Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. J Hypertens 28:1584–1590

    Article  CAS  PubMed  Google Scholar 

  • Corrao G, Parodi A, Nicotra F, Zambon A, Merlino L, Cesana G et al (2011) Better compliance to antihypertensive medications reduces cardiovascular risk. J Hypertens 29:610–618

    Article  CAS  PubMed  Google Scholar 

  • Coull AJ, Taylor VH, Elton R, Murdoch PS, Hargreaves AD (2004) A randomised controlled trial of senior Lay Health Mentoring in older people with ischaemic heart disease: The Braveheart Project. Age Ageing 33:348–354

    Article  PubMed  Google Scholar 

  • Cramer JA, Benedict A, Muszbek N, Keskinalsan A, Khan ZM (2008) The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract 62:76–87

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dabrh A, Gallacher K, Boehmer KR, Hargraves IG, Mair FS (2015) Minimally disruptive medicine: the evidence and conceptual progress supporting a new era of healthcare. J R Coll Physicians Edinb 45:114–117

    Article  PubMed  Google Scholar 

  • Dezii CM (2000) Medication noncompliance: what is the problem? Manag Care 9:7–12

    CAS  PubMed  Google Scholar 

  • DiMatteo MR (2004) Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol 23(2):207–218

    Article  PubMed  Google Scholar 

  • DiMatteo MR, Haskard KB, Williams SL (2007) Health beliefs, disease severity, and patient adherence. A meta-analysis. Med Care 45:521–528

    Article  PubMed  Google Scholar 

  • Drevenhorn E, Bengtson A, Nilsson PM, Nyberg P, Kjellgren KI (2012) Consultation training of nurses for cardiovascular prevention – a randomized study of 2 years duration. Blood Press 21(5):293–299

    Article  PubMed  Google Scholar 

  • Elmer PJ, Obarzanek E, Vollmer WM, Simons-Morton D, Stevens VJ, Young DR et al (2006) Effects of comprehensive lifestyle modification on diet, weight, physical fitness and blood pressure control: 18-month results of a randomized trial. Ann Intern Med 144:485–495

    Article  PubMed  Google Scholar 

  • ESH/ESC (2013) ESH/ESC Guidelines for the management of arterial hypertension. http://eurheartj.oxfordjournals.org/content/34/28/2159

  • Fischer M, Stedman M, Lii J, Vogeli C, Shrank W, Brookhart A, Weissman J (2010) Primary medication non-adherence: analysis of 195930 electronic prescriptions. J Gen Intern Med 24(4):284–290

    Article  Google Scholar 

  • Fishman T (1995) The 90-Second Intervention: a patient compliance mediated technique to improve and control hypertension. Public Health Rep 110(2):173–178

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fuster V (2012) An alarming threat to secondary prevention: low compliance (lifestyle) and poor adherence (drugs). Rev Esp Cardiol 65(Supl 2):10–16

    Article  PubMed  Google Scholar 

  • Fuster V, Kelly BB, Vedanthan R (2011) Promoting global cardiovascular health: moving forward. Circulation 123:1671–1678

    Article  PubMed  Google Scholar 

  • Gale NK, Greenfield S, Gill P, Gutridge K, Marshall T (2011) Patient and general practitioner attitudes to taking medication to prevent cardiovascular disease after receiving detailed information on risks and benefits of treatment: a qualitative study. BMC Fam Pract 12:59

    Article  PubMed  PubMed Central  Google Scholar 

  • Gallagher BD, Muntner P, Moise N et al (2015) Are two commonly used self-report questionnaires useful for identifying antihypertensive medication nonadherence? J Hypertens 33:1108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Glynn LG, Murphy AW, Smith SM, Schroeder K, Fahey T (2010) Interventions used to improve control of blood pressure in patients with hypertension. Cochrane Database Syst Rev

    Google Scholar 

  • Gragne JJ, Choudry NK, Kesselheim AS et al (2014) Comparative effectiveness of generic and brand-name statins on patient outcomes: a cohort study. Ann Intern Med 161:400

    Article  Google Scholar 

  • Gregorie JP, Moisan J, Gilbert R, Ciampi A, Milot A (2006) Predictors of self-reported compliance with antihypertensive drug treatment: a prospective study. Can J Cardiol 22:323–329

    Article  Google Scholar 

  • Guthrie B, Inkster M, Fahey T (2007) Tackling therapeutic inertia: role of treatment data in quality indicators. BMJ 335:542–544

    Article  PubMed  PubMed Central  Google Scholar 

  • Hansen RA, Kim MM, Song L, Tu W, Wu J, Murray MD (2009) Comparison of methods to asses medication adherence and classify non adherence. Ann Pharmacotner 43:413–422

    Article  Google Scholar 

  • Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X (2008) Interventions for enhancing medication adherence. Cochrane Database Syst Rev, Issue 2. Art. No.: CD000011. doi:10.1002/14651858.CD000011.pub3

  • Hedegaard U, Kjeldsen LJ, Pottegård A, Henriksen JE, Lambrechtsen J, Hangaard J, Hallas J (2015) Improving medication adherence in patients with hypertension: a randomized trial. Am J Med 128(12):1351–1361, PMID: 26302142

    Article  PubMed  Google Scholar 

  • Ho PM, Rumsfeld JS, Masoudi FA, McClure DL, Plomondon ME, Steiner JF et al (2006) Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med 166(17):1836–1841

    Article  PubMed  Google Scholar 

  • Horne R, Weinman J, Barber N, Elliott R, Myfanwy M (2005) Concordance, adherence and compliance in medicine taking. Report for the National Co-ordinating Centre for NHS Service Delivery and Organisation R & D (NCCSDO). http://www.sdo.nihr.ac.uk/files/project/76-final-report.pdf

  • Horne R, Clatworthy J, Hankins M (2010) High adherence and concordance within a clinical trial of antihypertensives. Chronic Illn 6:243–251

    Article  PubMed  Google Scholar 

  • Houle SK, Chatterley T, Tsuyuki RT (2014) Multidisciplinary approaches to the management of high blood pressure. Curr Opin Cardiol 29(4):344–353. doi:10.1097/HCO.0000000000000071

    Article  PubMed  Google Scholar 

  • Hughes DA, Bagust A, Haycox A, Walley T (2001) Accounting for noncompliance in pharmacoeconomic evaluations. Pharmacoeconomics 19:1185–1197

    Article  CAS  PubMed  Google Scholar 

  • Hypertension in adults: diagnosis and management NICE guidelines [CG127] Published date: August 2011 https://www.nice.org.uk/guidance/cg127/chapter/1-recommendations#patient-education-and-adherence-to-treatment

  • Inkster ME, Donnan PT, MacDonald TM (2006) Adherence to antihypertensive medication and association with patient and practice factors. J Hum Hypertens 20:295–297

    Article  CAS  PubMed  Google Scholar 

  • James P, Oparil S, Pharm B, Cushman W (2014) 2014 Evidence-based guideline for the management of high blood pressure in adults. Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311(5):507–520. doi:10.1001/jama.2013.284427

    Article  CAS  PubMed  Google Scholar 

  • James LL, Dimsdale J, Solomon D (2016) Psychological factors affecting other medical conditions: management. www.uptodate.com. UpToDate

  • Jung O, Gechter JL, Wunder C, Paulke A, Bartel C, Geiger H et al (2013) Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens 31:766–774

    Article  CAS  PubMed  Google Scholar 

  • Kaplan N, Bakris G, Forman J (2016) Patient adherence and the treatment of hypertension. www.uptodate.com.UpToDate

  • Kivimäki M, Batty GD, Hamer M, Nabi H, Korhonen M, Huupponen R, Pentti J, Oksanen T, Kawachi I, Virtanen M, Westerlund H, Vahtera J (2013) Retirement seems to be a major risk factor: influence of retirement on nonadherence to medication for hypertension and diabetes. CMAJ 185(17):E784–E790, PMID: 24082018

    Article  PubMed  PubMed Central  Google Scholar 

  • Klamerus ML, Kerr EA, Bosworth HB, Schmittdiel JA, Heisler M (2014) Characteristics of diabetic patients associated with achieving and maintaining blood pressure targets in the Adherence and Intensification of Medications program. Chronic Illn 10(1):60–73. doi:10.1177/1742395313496590

    Article  PubMed  Google Scholar 

  • Kronish IM, Woodward M, Sergie Z, Ogedegbe G, Falzon L, Mann DM (2011) Meta-analysis: impact of drug class on adherence to antihypertensives. Circulation 123(15):1611–1621, PMID: 21464050

    Article  PubMed  PubMed Central  Google Scholar 

  • Krousel-Wood M, Joyce C, Holt E, Muntner P, Webber LS, Morisky DE, Frohlich ED (2011) Predictors of decline in medication adherence: results from the cohort study of medication adherence among older adults. Hypertension 58:804–810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • LaFleur J, Nelson RE, Sauer BC, Nebeker JR (2011) Overestimation of the effects of adherence on outcomes: a case study in healthy user bias and hypertension. Heart 97(22):1862–1869, PMID: 21586421

    Article  PubMed  Google Scholar 

  • Lee JK, Grace KA, Taylor AJ (2006) Effect of a pharmacy care program on medication adherence and persistence, blood pressure and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA 296:2563–2571

    Article  CAS  PubMed  Google Scholar 

  • Luders S, Schrader J, Schmieder RE, Smolka W, Wegscheider K, Bestehorn K (2010) Improvement of hypertension management by structured physician education and feedback system: cluster randomized trial. Eur J Cardiovasc Prev Rehabil 17:271–279

    PubMed  Google Scholar 

  • Luiza VL, Chaves LA, Silva RM et al (2015) Pharmaceutical policies: effects of cap and copayment on rational use of medicines. Cochrane Database Syst Rev 5:CD007017

    Google Scholar 

  • Lundahl BW, Moleni T, Burke BL, Butters R, Tollefson D, Butler C et al (2013) Motivational interviewing in medical care settings: a systematic review and meta-analysis of randomized controlled trials. Patient Educ Couns 93(2):157–168. doi:10.1016/j.pec.2013.07.012

    Article  PubMed  Google Scholar 

  • Ma C, Zhou Y, Zhou W, Huang C (2014) Evaluation of the effect of motivational interviewing counselling on hypertension care. Patient Educ Couns 95(2):231–237. doi:10.1016/j.pec.2014.01.011

    Article  PubMed  Google Scholar 

  • MacFadyen RJ, Struthers AD (1997) The practical assessment of compliance with ACE-Inhibitor therapy-a novel approach. J Cardiovasc Pharmacol 29:119–124

    Article  CAS  PubMed  Google Scholar 

  • Machado M, Bajcar J, Guzzo GC, Einarson TR (2007) Sensitivity of patient outcomes to pharmacist interventions. Part II: Systematic review and meta-analysis in hypertension management. Ann Pharmacother 41:1770–1781

    Article  PubMed  Google Scholar 

  • Márquez E (2008) Evaluation of non-compliance in clinical practice. Hipertension 25:205–213

    Google Scholar 

  • Márquez Contreras E, Casado Martínez JJ, Ramos Gómez J, Sáenz Soubrier S, Moreno García JP, Celotti Gómez B et al (1998) Influence of medical adherence in blood pressure levels in the treatment of hypertension. Hipertension 5:133–139

    Google Scholar 

  • Márquez E, Gil V, Casado J, Martel N, de la Figuera M, Martín JL et al (2006a) Analysis of studies published on therapy non-compliance with hypertension treatment in spain between 1984 and 2005. Aten Primaria 38(6):325–332

    Article  Google Scholar 

  • Márquez E, Martell N, Gil VF, De la Figuera M, Casado JJ, Martín de Pablos JL et al (2006b) Efficacy of a home blood pressure monitoring programme on therapeutic compliance in hypertensión. The EAPACUM-HTA Study. J Hypertens 24:169–175

    Article  Google Scholar 

  • Márquez E, De la Figuera M, Franch J, Llisterri JL, Gil V, Martín de Pablos JL et al (2012) Do patients with high vascular risk take antihypertensive medication correctly? cumple-MEMS study. Rev Esp Cardiol 65:544–550

    Article  Google Scholar 

  • Marshall IJ, Wolfe CD, McKevitt C (2012) Lay perspectives on hypertension and drug adherence: systematic review of qualitative research. BMJ 345:e3953, PMID: 22777025

    Article  PubMed  PubMed Central  Google Scholar 

  • May C, Montori VM, Mair FS (2009) We need minimally disruptive medicine. BMJ 339:b2803, doi: http://dx.doi.org/10.1136/bmj.b2803

    Article  PubMed  Google Scholar 

  • Mayor S (2013) Non-adherence to medication increases stroke risk in patients with high blood pressure. BMJ 347:f4586, PMID: 23863964

    Article  PubMed  Google Scholar 

  • Mazzaglia G, Ambrosioni E, Alacqua M, Filippi A, Sessa E, Immordino V et al (2009) Adherence to antihypertensive medications and cardiovascular morbidity among newly diagnosed hypertensive patients. Circulation 120(16):1598–1605. doi:10.1161/circulationaha.108.830299

    Article  CAS  PubMed  Google Scholar 

  • McCarthy R (1998) The price you pay for the drug not taken. Bus Health 16:27–33

    CAS  PubMed  Google Scholar 

  • McManus RJ, Mant J, Bray EP, Holder R, Jones MI, Greenfield S et al (2010) Telemonitoring and self-management in the control of hypertension (TASMINH2): a randomised controlled trial. Lancet 376:163–172

    Article  PubMed  Google Scholar 

  • Medding J, Kerr E, Heisler M, Hofer T (2012) Physician assessments of medication adherence and decisions to intensify medications for patients with uncontrolled blood pressure: still no better than acoin toss. BMC Health Serv Res 12:270. doi:10.1186/1472-6963-12-270

    Article  Google Scholar 

  • Miller W, Rollnick S (2013) Motivational interviewing, 3rd edn. The Guilford Press, New York

    Google Scholar 

  • Morak J, Kumpusch H, Hayn D, Modre-Osprian R, Schreier G (2012) Design and evaluation of a telemonitoring concept based on NFC-enabled mobile phones and sensor devices. IEEE Trans Inf Technol Biomed Publ IEEE Eng Med Biol Soc 16:17–23

    Article  Google Scholar 

  • Morisky DE, Green LW, Levine DM (1986) Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 24:67–74

    Article  CAS  PubMed  Google Scholar 

  • Morisky DE, Ang A, Krousel-Wood M, Ward H (2008) Predictive validity of a medication adherence measure for hypertension control. J Clin Hypertens 10:348–354

    Article  Google Scholar 

  • Morris AB, Pharm D, Jingjin L, Kroenke K, Bruner-England TE, Young JM, Murray MD (2006) Factors associated with drug adherence and blood pressure control in patients with hypertension. Pharmacotherapy 26:483–492

    Article  PubMed  Google Scholar 

  • Muntner P, Mann D, Wildman RP, Shimbo D, Fuster V, Woodward M (2011) Projected impact of polypill use among US adults: medication use, cardiovascular risk reduction, and side effects. Am Heart J 161:719–725

    Article  PubMed  PubMed Central  Google Scholar 

  • New England Healthcare Institute (2009) Thinking outside the pillbox. A system-wide approach to improving patient medication adherence for chronic disease. http://wwwnehi.net/uploads/full_report/pa_issue_brief__final.pdf

  • Newby LK, LaPointe NM, Chen AY, Kramer JM, Hammill BG, DeLong ER, Muhlbaier LH et al (2006) Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease. Circulation 113:203–212

    Article  CAS  PubMed  Google Scholar 

  • O’Halloran PD, Blackstock F, Shields N, Holland A, Iles R, Kingsley M et al (2014) Motivational interviewing to increase physical activity in people with chronic health conditions: a systematic review and meta-analysis. Clin Rehabil 28(12):1159–1171. doi:10.1177/0269215514536210

    Article  PubMed  Google Scholar 

  • OECD Health Policy Studies. Improving health sector. Efficiency the role of information and communication technologies. Online at www.oecd.org/publishing/corrigenda

  • Oegdegbe G, Harrison M, Robbins L et al (2004) Barriers and facilitators of medicationa adherence in hypertensive African Americans: a qualitative study. Ethn Dis 14(1):3–12

    Google Scholar 

  • Osterberg L, Blaschke T (2005) Adherence to medication. N Engl J Med 353(5):487–497

    Article  CAS  PubMed  Google Scholar 

  • Paasche-Orlow M (2011) Caring for patients with limited health literacy: a 76-year-old man with multiple medical problems. JAMA 306(10):1122–1129. doi:10.1001/jama.2011.1203

    Article  CAS  PubMed  Google Scholar 

  • Parati G, Omboni S, Albini F, Piantoni L, Giuliano A, Revera M et al (2009) Home blood pressure telemonitoring improves hypertension control in general practice. The TeleBPCare study. J Hypertens 27:198–203

    Article  CAS  PubMed  Google Scholar 

  • Parati G, Stergiou GS, Asmar R, Bilo G, de Leeuw P, Imai Y et al (2010) European Society of Hypertension practice guidelines for home blood pressure monitoring. J Hum Hypertens 24:779–785

    Article  CAS  PubMed  Google Scholar 

  • Pladevall M, Brotons C, Gabriel R, Arnau A, Suárez C, De la Figuera M et al (2010) Multicenter cluster-randomized trial of a mukltifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study). Circulation 122:1183–1191

    Article  PubMed  PubMed Central  Google Scholar 

  • Qureshi NN, Hatcher J, Chaturvedi N, Jafar TH (2007) Effect of general practitioner education on adherence to antihypertensive drugs: cluster randomised controlled trial. BMJ 335:1030

    Article  PubMed  PubMed Central  Google Scholar 

  • Redon J, Coca A, Lazaro P, Aguilar MD, Cabanas M, Gil N et al (2010) Factors associated with therapeutic inertia in hypertension: validation of a predictive model. J Hypertens 28:1770–1777

    Article  CAS  PubMed  Google Scholar 

  • Rosen MI, Rigsby MO, Salahi JT, Ryan CE, Cramer JA (2004) Electronic monitoring and counseling to improve medication adherence. Behav Res Ther 42(4):409–422

    Article  PubMed  Google Scholar 

  • Rosenson RS, Braun LT, Freeman MW, Gersh BJ, Rind DM (2016) Compliance with lipid altering medications and recommended lifestyle changes. www.uptodate.com. UpToDate.

  • Roshanov PS, Misra S, Gerstein HC, Garg AX, Sebaldt RJ, Mackay JA et al (2011) Computerized clinical decision support systems for chronic disease management: a decision-maker-researcher partnership systematic review. Implement Sci 6:92. doi:10.1186/1748-5908-6-92

    Article  PubMed  PubMed Central  Google Scholar 

  • Ross S, Walker A, MacLeod MJ (2004) Patient compliance in hypertension: role of illness perceptions and treatment beliefs. J Hum Hypertens 18(9):607–613

    Article  CAS  PubMed  Google Scholar 

  • Russell M, Roe B, Beech R, Russell W (2009) Service developments for managing people with long-term conditions using case management approaches, an example from the UK. Int J Integr Care 9:e02

    Article  PubMed  PubMed Central  Google Scholar 

  • Sackett DL, Haynes RB (1976) Compliance with therapeutic regimens. The Johns Hopkins University Press, Baltimore

    Google Scholar 

  • Sackett DL, Haynes RB, Gibson ES (1975) Randomized clinical trial of stategies for improving medication compliance in primary hypertension. Lancet 1:1205–1217

    Article  CAS  PubMed  Google Scholar 

  • Sanson-Fisher R, Clover K (1995) Compliance in the treatment of hypertension. A need of action. Am J Hypertens 8:82S–88S

    Article  CAS  PubMed  Google Scholar 

  • Santschi V, Rodonti N, Bugnon O, Burnier M (2008) Impact of electronic monitoring of drug adherence on blood pressure control in primary care: a cluster 12-month randomised controlled study. Eur J Intern Med 19:427–434

    Article  PubMed  Google Scholar 

  • Schoenthaler A, Ogedegbe G (2008) Patients’ perceptions of electronic monitoring devices affect medication adherence in hypertensive African Americans. Ann Pharmacotherar 42:647–652

    Article  Google Scholar 

  • Schroeder K, Fahey T, EbrahimS (2004) Interventions for improving adherence to treatment in patients with high blood pressure in ambulatory settings. Cochrane Database Syst Rev Issue 3. Art. No.: CD004804. doi:10.1002/14651858.CD004804

  • Shanti M, Maribel S (2003) Hypertension. World Health Organization. p 98–104

    Google Scholar 

  • Shea K, Chamoff B (2012) Telehomecare communication and self-care in chronic conditions: moving toward a shared understanding. Worldviews Evid Based Nurs/Sigma Theta Tau Int Honor Soc Nurs 9:109–116

    Article  Google Scholar 

  • Sherbourne C, Hays RD, Ordway L, DiMattteo HR (1992) Antecedents of adherence to medical recommendations: results from the Medical Outcomes Study. J Behav Med 1:447–468

    Article  Google Scholar 

  • Sicras A, Fernández J, Rejas J, García M (2006) Antihypertensive and/or lipid-lowering treatments pattern of compliance in hypertense and/or dyslipemic patients in Primary Care. An Med Interna 23:361–368

    Google Scholar 

  • Stephenson BJ, Rowe BH, Haynes RB, Macharia WM, Leon G (1993) The rational clinical examination. Is this patient taking the treatment as prescribed? JAMA 269(21):2779–2781

    Article  CAS  PubMed  Google Scholar 

  • Stergiou G, Myers MG, Reid JL, Burnier M, Narkiewicz K, Viigimaa M et al (2010) Setting-up a blood pressure and vascular protection clinic: requirements of the European Society of Hypertension. J Hypertens 28:1780–1781

    Article  CAS  PubMed  Google Scholar 

  • Stewart K, George J, Mc Namara KP, Jackson SL, Peterson GM, Bereznicki LR et al (2014) Multifaceted pharmacist intervention to improve antihypertensive adherence: a cluster-randomized, controlled trial (HAPPy trial). J Clin Pharm Ther 39(5):527–534. doi:10.1111/jcpt.12185

    Article  CAS  PubMed  Google Scholar 

  • Susan J (2015) USA grapples with high drug costs. Lancet 386:2127

    Article  Google Scholar 

  • Tamblyn R, Eguale T, Huang A, Winslade N, Doran P (2014) The incidence and determinants of primary non adherence with prescribed medication in primary care: a cohort study. Ann Intern Med 160:441–450

    Article  PubMed  Google Scholar 

  • The effect of treatment on mortality in “mild” hypertension: results of the Hypertension Detection and Follow-up Program (1982) N Engl J Med 307:976–980

    Google Scholar 

  • Tinsel I, Buchholz A, Vach W, Siegel A, Dürk T, Buchholz A et al (2013) Decision-making in antihypertensive therapy: a cluster randomised controlled trial. BMC Fam Pract 14:135. doi:10.1186/1471-2296-14-135

    Article  PubMed  PubMed Central  Google Scholar 

  • Tomaszewski M, White C, Patel P, Masca N, Damani R, Hepworth J et al (2014) High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis. Heart 100:855–861

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uhlig K, Patel K, Ip S, Kitsios GD, Balk EM (2013) Self-measured blood pressure monitoring in the management of hypertension: a systematic review and meta-analysis. Ann Intern Med 159:185–194

    Article  PubMed  Google Scholar 

  • van Duijn HJ, Belo JN, Blom JW, Velberg ID, Assendelft WJ (2011) Revised guidelines for cardiovascular risk management – time to stop medication? A practice-based intervention study. Br J Gen Pract 61(587):e347–e352. doi:10.3399/bjgp11X578025

    Article  PubMed  PubMed Central  Google Scholar 

  • VanBuskirk KA, Wetherell JL (2014) Motivational interviewing with primary care populations: a systematic review and meta-analysis. J Behav Med 37(4):768–780. doi:10.1007/s10865-013-9527-4

    Article  PubMed  Google Scholar 

  • Vedanthan R, Kamano JH, Naanyu V, Delong AK, Were MC, Finkelstein EA et al (2014) Optimizing linkage and retention to hypertension care in rural Kenya (LARK hypertension study): study protocol for a randomized controlled trial. Trials 15:143. doi:10.1186/1745-6215-15-143

    Article  PubMed  PubMed Central  Google Scholar 

  • Walsh JM, McDonald KM, Shojania KG, Sundaram V, Nayak S, Lewis R et al (2006) Quality improvement strategies for hypertension management: a systematic review. Med Care 44:646–657

    Article  PubMed  Google Scholar 

  • Wang W, Lau Y, Loo A, Chow A, Thompson DR (2014) Medication adherence and its associated factors among Chinese community-dwelling older adults with hypertension. Heart Lung 43(4):278–283, PMID: 24856232

    Article  PubMed  Google Scholar 

  • WHO (2004) Adherence to long-therm therapics. Evidence for action. Geneva: World Health Organization. http://apps.who.int/iris/bitstream/10665/42682/1/9241545992.pdf

  • Zeller A, Schoroeder K, Peters T (2007) Electronic pillboxes (MEMS) to asses the relatioshep between medication adherence and and blood pressure control in primary care. Scand J Prim Health Care 25:202–207

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Mariñamansa-A Cuña Health Center, Galician Health Service, Centro de Saúde Marinamansa – A Cuña, Dr. Peña Rey 2b, SERGAS (Servicio Galego de Saúde), CP 32005, Ourense, Spain

    Carlos Menéndez Villalva & Xosé Luís López Alvarez-Muiño

  2. Pontedeva Health Center, Galician Health Service, Ourense, Spain

    Trinidad Gamarra Mondelo

  3. Carballo Health Center, Galician Health Service, Corunna, Spain

    Alfonso Alonso Fachado

  4. University Hospital Center of Ourense, Ourense, Spain

    Joaquín Cubiella Fernández

Authors
  1. Carlos Menéndez Villalva
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  2. Xosé Luís López Alvarez-Muiño
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  3. Trinidad Gamarra Mondelo
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  4. Alfonso Alonso Fachado
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  5. Joaquín Cubiella Fernández
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Corresponding author

Correspondence to Carlos Menéndez Villalva .

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Editors and Affiliations

  1. Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden

    Md. Shahidul Islam

  2. Department of Internal Medicine and Emergency Medicine, Uppsala University Hospital, Uppsala, Sweden

    Md. Shahidul Islam

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Villalva, C.M., Alvarez-Muiño, X.L.L., Mondelo, T.G., Fachado, A.A., Fernández, J.C. (2016). Adherence to Treatment in Hypertension. In: Islam, M.S. (eds) Hypertension: from basic research to clinical practice. Advances in Experimental Medicine and Biology(), vol 956. Springer, Cham. https://doi.org/10.1007/5584_2016_77

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  • DOI: https://doi.org/10.1007/5584_2016_77

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-44250-1

  • Online ISBN: 978-3-319-44251-8

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