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IgA Nephropathy in Children: A Multicenter Study in Poland

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Advancements in Clinical Research

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 952))

Abstract

IgA nephropathy (IgAN) is the most common form of glomerulonephritis in pediatric population. The clinical presentation of the disease in children ranges from microscopic hematuria to end-stage kidney disease. The aim of the study was to retrospectively assess clinical and kidney biopsy features in children with IgAN. We assessed a cohort of 140 children, 88 boys, 52 girls with the diagnosis of IgAN in the period of 2000–2015, entered into the national Polish pediatric IgAN registry. The assessment included the following: proteinuria, hematuria, glomerular filtration rate (GFR), arterial blood pressure, and the renal pathological changes according to the Oxford classification and crescents formation, as modifiable and unmodifiable risk factors. The incidence of IgAN in Poland was set at 9.3 new cases per year. The mean age at onset of IgAN was 11.9 ± 4.3 years, and the most common presentation of the disease was the nephritic syndrome, recognized in 52 % of patients. Kidney biopsy was performed, on average, 1.3 ± 2.0 years after onset of disease. Based on the ROC analysis, a cut-off age at onset of disease for GFR <90 mL/min/1.73 m2 (risk factor of progression) was calculated as 13.9 years. Unmodifiable lesions: segmental sclerosis, tubular atrophy/interstitial fibrosis (S1, T1-2) in the Oxford classification and crescents in kidney biopsy were significantly more common in Gr 1 (>13.9 years) compared with Gr 2 (<13.9 years), despite a significantly shorter time to kidney biopsy in the former. We conclude that IgAN in children may be an insidious disease. A regular urine analysis, especially after respiratory tract infections, seems the best way for an early detection of the disease.

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Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Author information

Authors and Affiliations

  1. Department of Pediatrics and Nephrology, Medical University of Warsaw, 63A Zwirki i Wigury Street, 02-091, Warsaw, Poland

    M. Mizerska-Wasiak, A. Turczyn, A. Such, K. Cichoń-Kawa & M. Pańczyk-Tomaszewska

  2. Department of Pathology, Medical University of Warsaw, Warsaw, Poland

    J. Małdyk

  3. Department of Pediatric Nephrology, Jagiellonian University, Cracow, Poland

    M. Miklaszewska & J. Pietrzyk

  4. Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland

    A. Rybi-Szumińska & A. Wasilewska

  5. Department of Pediatrics and Nephrology, Ludwik Rydygier Hospital, Torun, Poland

    A. Firszt-Adamczyk & R. Stankiewicz

  6. Department of Pediatrics, SMDZ in Zabrze, Silesian Medical University, Katowice, Poland

    M. Szczepańska

  7. Department of Pediatric Nephrology, Medical University of Lublin, Lublin, Poland

    B. Bieniaś & M. Zajączkowska

  8. Department of Pediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland

    A. Pukajło-Marczyk & D. Zwolińska

  9. Department of Pediatrics, Immunology and Nephrology, Polish Mothers Memorial Hospital Research Institute, Lodz, Poland

    K. Siniewicz-Luzeńczyk & M. Tkaczyk

  10. Department of Nephrology, Kidney Transplantation and Hypertension, Children’s Memorial Health Institute, Warsaw, Poland

    K. Gadomska-Prokop & R. Grenda

  11. Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland

    U. Demkow

Authors
  1. M. Mizerska-Wasiak
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  2. A. Turczyn
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  3. A. Such
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  4. K. Cichoń-Kawa
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  5. J. Małdyk
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  6. M. Miklaszewska
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  7. J. Pietrzyk
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  8. A. Rybi-Szumińska
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  9. A. Wasilewska
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  10. A. Firszt-Adamczyk
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  11. R. Stankiewicz
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  12. M. Szczepańska
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  13. B. Bieniaś
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  14. M. Zajączkowska
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  15. A. Pukajło-Marczyk
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  16. D. Zwolińska
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  17. K. Siniewicz-Luzeńczyk
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  18. M. Tkaczyk
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  19. K. Gadomska-Prokop
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  20. R. Grenda
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  21. U. Demkow
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  22. M. Pańczyk-Tomaszewska
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Corresponding author

Correspondence to M. Mizerska-Wasiak .

Editor information

Editors and Affiliations

  1. Public Higher Medical Professional School in Opole, Institute of Nursing, Opole, Poland

    Mieczyslaw Pokorski

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Mizerska-Wasiak, M. et al. (2016). IgA Nephropathy in Children: A Multicenter Study in Poland. In: Pokorski, M. (eds) Advancements in Clinical Research. Advances in Experimental Medicine and Biology(), vol 952. Springer, Cham. https://doi.org/10.1007/5584_2016_65

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