Abstract
Antibiotics directly inhibit the growth and kill microorganisms, and many of them have immunomodulatory properties. We investigated the influence of cefotaxime and gentamicin on the release of neutrophil extracellular traps (NETs) – recently described strategy employed by neutrophils to fight infections. We found that gentamicin inhibits NETs release by human neutrophils, while cefotaxime did not have any impact on this process. The information that antibiotics can modulate NETs release, can be useful in the therapy of infectious diseases in patients suffering from NET-related diseases.
The original version of this chapter has been revised. An erratum to this chapter can be found at DOI 10.1007/978-3-319-44488-8_11
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Acknowledgments
This study was supported by a Grant for Young Scientist no. 1WW/PM11/15/15 funded by the Dean of the First Faculty of Medicine, Warsaw Medical University in Warsaw, Poland.
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The authors declare no conflicts of interest in relation to this article.
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Manda-Handzlik, A., Bystrzycka, W., Sieczkowska, S., Demkow, U., Ciepiela, O. (2016). Antibiotics Modulate the Ability of Neutrophils to Release Neutrophil Extracellular Traps. In: Pokorski, M. (eds) Respiratory Treatment and Prevention. Advances in Experimental Medicine and Biology(), vol 944. Springer, Cham. https://doi.org/10.1007/5584_2016_59
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DOI: https://doi.org/10.1007/5584_2016_59
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